Results
Title

Novel Quinolinyl - Sulphonamide Hybrid Schiff Bases as Potent Radical Scavengers to Combat Oxidative Stress.

Authors

Munir, Rubina; Zia-ur-Rehman, Muhammad; Athar, Muhammad Makshoof; Javid, Noman; Roohi, Ayesha; Razavi, Syeda Fatima

Abstract

Eight novel quinolinyl-sulphonamide based Schiff bases have been prepared by condensation of substituted 2-chloroquinoline-3-carbaldehydes with sulphonamide substituted benzoic acid hydrazides. Structures of the Schiff bases have been confirmed by spectral techniques including FT-IR, 1H-NMR, 13CNMR, and mass spectroscopies. The purity of compounds has been established by elemental analysis. Free-radical scavenging activity of these compounds has been carried out by DPPH assay that showed these compounds to be effective radical scavengers. The compounds 7a, 7b, 7d, 7f and 7h have exhibited radical scavenging activity better than the reference compound BHT.

Subjects

SCHIFF bases; SULFONAMIDES; OXIDATIVE stress; BENZOATES; MASS spectrometry; BENZOIC acid

Publication

Pakistan Journal of Zoology, 2021, Vol 53, Issue 1, p87

ISSN

0030-9923

Publication type

Academic Journal

DOI

10.17582/journal.pjz/20190620180646