In vivo Anti-Diabetic Studies of Sulfonylurea-Sulfonamide Hybrids.

Ahmad, Tanveer; Mehmood, Tariq; Shahid, Muhammad; Ahmad, Adnan; Raza Basra, Muhammad Asim; Zia-ur-Rehman, Muhammad; Munawar, Munawar Ali

Owing to alarming increase of diabetes mellitus around the world, there is a need to discover new molecules to tackle with the problem. In this work, sulfonamides and sulfonylurea-sulfonamide hybrids were synthesized from simple molecule of 4-aminobenzenesulfonamide by its reaction with aryl sulfonyl chlorides. Anti-diabetic activities of these pharmacophores were studied by oral glucose tolerance test (OGTT) percentage analysis on Sprague Dawley (SD) rats at the dose of 20mg/kg using glibenclamide (GC). Among these synthesized pharmacophores, six compounds exhibited percentage reduction (20.47±2.54 to 44.97±2.16 %) and (20.79±1.55 to 37±2.94 %) in blood glucose level at 20mg/kg dose compared to glibenclamide (74±3.10 % reduction) 50mg/kg dose of glibenclamide after 2 and 5 hours of oral administration respectively. Present results showed that these compounds might be excellent addition in the drugs used to suppress the higher level of blood glucose level in diabetes mellitus.

GLUCOSE tolerance tests; BLOOD sugar; IN vivo studies; SULFONYL chlorides; ARYL chlorides; SULFONAMIDES; SULFONYL compounds; DIABETES

Pakistan Journal of Zoology, 2020, Vol 52, Issue 3, p857

0030-9923

Academic Journal

10.17582/journal.pjz/20190614140636