Combination Effect of Argan Oil and Low Frequency Electromagnetic Field on Open Wound in Mice.

MASRE, SITI F.; M. K., MUZAMIR; I., SABARINA; N., JEHAN; ROSLI, YANTI

This study was conducted to evaluate the effect of argan oil with the exposure of low frequency electromagnetic field (EMF) on open wound healing in mice. Eighteen male mice (20-40 g) were divided into three groups: phosphate buffer saline (PBS) as negative control, solcoseryl gel as positive control, and argan oil with the exposure of low frequency EMF, 1.2 mT (treatment group). Full thickness wounds (4 mm diameter) were induced on the shaved dorsal of the mouse. All mice were sacrificed on day 12 after the final treatment. Macroscopic observation, wound contraction rate, histopathology analysis and total protein content were examined in this study. Results showed that wounds treated with argan oil and exposed to low frequency EMF has a significant increase in wound contraction rate (p < 0.05) and total protein content (p < 0.05). Moreover, histopathological analysis on the wound tissues displayed complete re-epithelization with thick and dense collagen fibers in the argan oil with low frequency EMF exposure treated group. In conclusion, topical treatment of argan oil with low frequency EMF exposure yield a better healing progress and showed the ability to accelerate wound healing.

ARGAN oil; WOUND healing; ELECTROMAGNETIC fields; PHYSIOLOGICAL effects of electromagnetism; WOUND care; PLANT proteins; MICE; WOUNDS & injuries; THERAPEUTICS

Malaysian Journal of Health Sciences / Jurnal Sains Kesihatan Malaysia, 2018, Vol 16, p41

1675-8161

Academic Journal

10.17576/JSKM-2018-07