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- Title
One Step Fabrication of Hollow and Highly Flexible Polydimethylsiloxane Microneedles.
- Authors
Cakmak, Soner
- Abstract
In this study, the hollow and highly flexible polydimethylsiloxane microneedles were fabricated in a one step and simple design. For this purpose, a commercial dermastamping device (Dermastamp® 140 DRS) was used as a mold to obtain highly flexible PDMS microneedles containing channels. With the proposed design, microneedles with a total height of 1500 µ m, 1500 µ m center-to-center spacing and 150 µ m channel diameter was successfully fabricated. These data are all compatible with the dimensions and the geometry of the mold used. Then, a syringe adapter was fabricated with a 3D printer and combined with the hollow PDMS microneedle patch for the high-throughput production of alginate beads. After the adapter and the hollow PDMS microneedle patch combination was placed into the syringe pump, the mostly spherical alginate beads with a mean diameter of 2.0 ± 0.3 mm was produced. To sum up, the proposed design and fabrication scheme first offer a novel and simple strategy for the fabrication of hollow polymeric microneedles. Moreover, this system has the potential to be used not only for the high-throughput microfluidic fabrication of polymeric beads, but also in controlled drug delivery systems and cell encapsulation studies.
- Subjects
MICROFABRICATION; DRUG delivery systems; MICROFLUIDICS; THREE-dimensional printing; DATA analysis
- Publication
Hittite Journal of Science & Engineering, 2022, Vol 9, Issue 3, p219
- ISSN
2149-2123
- Publication type
Academic Journal
- DOI
10.17350/HJSE19030000274