Evaluation of Systemic and Hematological Inflammatory Markers in Patients with Vitamin D Deficiency.

ALISIK, Tugba

Objective: This study aims to comprehensively examine the effects of vitamin D (VD) on systemic and hematological inflammatory markers. Material and Method: A total of 2889 patients with albumin, C-reactive protein (CRP), creatinine and leukocyte values within the reference ranges were included in this retrospective study. Patients were divided into three groups based on their 25-hydroxy VD levels: group-1 (VD deficiency, VD20 ng/mL (50 nmol/L)) groups. CRP-albumin ratio (CAR), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), and prognostic nutritional index (PNI) were calculated. Results: The age of the groups did not differ significantly (p=0.094), while the percentage of females was significantly higher in group-1 than in group-2 and group-3 (p<0.05). CRP, CAR, and PLR values were significantly lower in group-2 and group-3 compared to group-1 (p<0.05 for all). Albumin and PNI values were significantly higher in group-2 and group-3 compared to group-1 (p<0.05 for all). In the multinomial multivariate logistic regression analysis, conducted using sex, CAR, PNI, NLR, PLR, and LMR parameters with group-3 as the reference category, significant odds ratios (OR) were observed for female sex, CAR, and PNI in relation to group-1. Conclusions: These results show that there were increases in CAR and PNI, markers of inflammation and nutritional status, in the VD-deficient population, although routine laboratory parameters were normal.

VITAMIN D deficiency; BLOOD platelets; MONOCYTE lymphocyte ratio; INFLAMMATION; PLATELET lymphocyte ratio; LEUKOCYTES; NEUTROPHIL lymphocyte ratio; LOGISTIC regression analysis

Medical Journal of Suleyman Demirel University, 2024, Vol 31, Issue 4, p296

1300-7416

Academic Journal

10.17343/sdutfd.1456455