Results
Title

FERROPTOSIS AND CIRCULAR RNAS: NEW HORIZONS IN CANCER THERAPY.

Authors

Bhat, Asif Ahmad; Kukreti, Neelima; Afzal, Muhammad; Goyal, Ahsas; Thapa, Riya; Ali, Haider; Shahwan, Moyad; Almalki, Waleed Hassan; Kazmi, Imran; Alzarea, Sami I.; Singh, Sachin Kumar; Dua, Kamal; Gupta, Gaurav

Abstract

Cancer poses intricate challenges to treatment due to its complexity and diversity. Ferroptosis and circular RNAs (circRNAs) are emerging as innovative therapeutic avenues amid the evolving landscape of cancer therapy. Extensive investigations into circRNAs reveal their diverse roles, ranging from molecular regulators to pivotal influencers of ferroptosis in cancer cell lines. The results underscore the significance of circRNAs in modulating molecular pathways that impact crucial aspects of cancer development, including cell survival, proliferation, and metastasis. A detailed analysis delineates these pathways, shedding light on the molecular mechanisms through which circRNAs influence ferroptosis. Building upon recent experimental findings, the study evaluates the therapeutic potential of targeting circRNAs to induce ferroptosis. By identifying specific circRNAs associated with the etiology of cancer, this analysis paves the way for the development of targeted therapeutics that exploit vulnerabilities in cancer cells. This review consolidates the existing understanding of ferroptosis and circRNAs, emphasizing their role in cancer therapy and providing impetus for ongoing research in this dynamic field.

Subjects

CARCINOGENESIS; ETIOLOGY of cancer; CIRCULAR RNA; CANCER treatment; CANCER cells

Publication

EXCLI Journal, 2024, Vol 23, p570

ISSN

1611-2156

Publication type

Academic Journal

DOI

10.17179/excli2024-7005