Title: Pharmacogenetics of β-Blockers.
Authors: Jaekyu Shin; Johnson, Julia A.
Abstract: β-Blockers are an important cardiovascular drug class, recommended as first-line treatment of numerous diseases such as heart failure, hypertension, and angina, as well as treatment after myocardial infarction. However, responses to a β-blocker are variable among patients. Results of numerous studies now suggest that genetic polymorphisms may contribute to variability in responses to β-blockers. This review summarizes the pharmacogenetic data for β-blockers in patients with various diseases and discusses the potential implications of β-blocker pharmacogenetics in clinical practice.
Subjects: ADRENERGIC beta blockers; CARDIOVASCULAR agents; DISEASES; THERAPEUTICS; GENETIC polymorphisms; MYOCARDIAL infarction
Publication: Pharmacotherapy, 2007, Vol 27, Issue 6, p874
ISSN: 0277-0008
Publication type: Academic Journal
DOI: 10.1592/phco.27.6.874

Pharmacogenetics of β-Blockers.

Jaekyu Shin; Johnson, Julia A.