Results
Title

Scrotal abscess caused by Candida glabrata in a patient with uncontrolled diabetes mellitus and chronic renal failure.

Authors

Tüz, Mehmet Ali; Ecer, Derya Tuna; Atik, Tuğba Kula; Yapıcı, Oktay

Abstract

Candida glabrata is a yeast which incidence has increased in recent years and usually causes urogenital and bloodstream infections. Its resistance to fluconazole hinders C. glabrata infections treatment. This case report presents a case of candidemia and scrotal abscess caused by C. glabrata, which was successfully treated with liposomal amphotericin B. The primary treatment options for C. glabrata candidemia are echinocandins and amphotericin B formulations. However, echinocandins and lipid-based amphotericin B formulations do not properly pass through the urinary system. Amphotericin B deoxycholate has a high risk of side effects and is difficult to obtain. The treatment option for candidemia caused by fluconazole-resistant C. glabrata secondary to urinary tract infection is unclear and there are no sufficient studies. For treatment, liposomal amphotericin B may be considered, especially for scrotal and prostatic fluconazole-resistant fungal abscesses. More studies comparing the penetration of antifungals into scrotal and prostatic tissue and the success of antifungal treatment in these tissue infections are needed.

Subjects

URINARY tract infections; AMPHOTERICIN B; CHRONIC kidney failure; CANDIDEMIA; ANTIFUNGAL agents

Publication

Revista do Instituto de Medicina Tropical de São Paulo, 2024, Vol 66, p1

ISSN

0036-4665

Publication type

Academic Journal

DOI

10.1590/S1678-9946202466071