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- Title
Scrotal abscess caused by Candida glabrata in a patient with uncontrolled diabetes mellitus and chronic renal failure.
- Authors
Tüz, Mehmet Ali; Ecer, Derya Tuna; Atik, Tuğba Kula; Yapıcı, Oktay
- Abstract
Candida glabrata is a yeast which incidence has increased in recent years and usually causes urogenital and bloodstream infections. Its resistance to fluconazole hinders C. glabrata infections treatment. This case report presents a case of candidemia and scrotal abscess caused by C. glabrata, which was successfully treated with liposomal amphotericin B. The primary treatment options for C. glabrata candidemia are echinocandins and amphotericin B formulations. However, echinocandins and lipid-based amphotericin B formulations do not properly pass through the urinary system. Amphotericin B deoxycholate has a high risk of side effects and is difficult to obtain. The treatment option for candidemia caused by fluconazole-resistant C. glabrata secondary to urinary tract infection is unclear and there are no sufficient studies. For treatment, liposomal amphotericin B may be considered, especially for scrotal and prostatic fluconazole-resistant fungal abscesses. More studies comparing the penetration of antifungals into scrotal and prostatic tissue and the success of antifungal treatment in these tissue infections are needed.
- Subjects
URINARY tract infections; AMPHOTERICIN B; CHRONIC kidney failure; CANDIDEMIA; ANTIFUNGAL agents
- Publication
Revista do Instituto de Medicina Tropical de São Paulo, 2024, Vol 66, p1
- ISSN
0036-4665
- Publication type
Academic Journal
- DOI
10.1590/S1678-9946202466071