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- Title
Is disorganized schizophrenia a predictor of treatment resistance? Evidence from an observational study.
- Authors
Bertolucci Ortiz, Bruno; de Araújo Filho, Gerardo Maria; Ga delha de Alencar Araripe Neto, Ary; Medeiros, Daiane; Affonseca Bressan, Rodrigo
- Abstract
Objective: To investigate whether inpatients with disorganized schizophrenia are more resistant to treatment. Method: Eighty-five inpatients were assessed at admission and at discharge for schizophrenia subtype, symptom severity, and treatment resistance criteria. Results: Disorganized patients were significantly more treatment-resistant than paranoid patients (60%, p = 0.001), and presented worse scores on the Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impression Scale (CGI-S), and the Global Assessment of Functioning Scale (GAF) (p < 0.001). Although the difference was not significant, 80% of treatment-resistant patients with disorganized schizophrenia responded to clozapine. Conclusion: Patients with the disorganized subtype of schizophrenia should benefit from clozapine as a second-line agent.
- Subjects
SCHIZOPHRENIA; SCHIZOAFFECTIVE disorders; PEOPLE with paranoid schizophrenia; PATHOLOGICAL psychology; CLOZAPINE; ANTIDEPRESSANTS; THERAPEUTICS
- Publication
Brazilian Journal of Psychiatry / Revista Brasileira de Psiquiatria, 2013, Vol 35, Issue 4, p432
- ISSN
1516-4446
- Publication type
Academic Journal
- DOI
10.1590/1516-4446-2013-1190