Works matching DE "LIGAND binding (Biochemistry)"

Results: 3918

Development and evaluation of [11C]DPA-813 and [18F]DPA-814: novel TSPO PET tracers insensitive to human single nucleotide polymorphism rs6971.

Published in:

European Journal of Nuclear Medicine & Molecular Imaging, 2025, v. 52, n. 7, p. 2658, doi. 10.1007/s00259-025-07109-1

By:

Beaino, Wissam;
JM Kooijman, Esther;
Werry, Eryn L.;
Vellinga, Rens J.;
Van den Hoek, Johan;
Sohler, Greta;
Cumbers, Grace A.;
Genetzakis, Elijah;
Harvey-Latham, Edward D.;
Schuit, Robert C.;
Kassiou, Michael;
Windhorst, Albert D.;
Danon, Jonathan J.

Publication type:

Article

Discovery of Lithospermate B as a Potential Ligand for the Malarial E2 Ubiquitin-Conjugating Enzyme via Multiplexed Native Mass Spectrometry.

Published in:

Chemosensors, 2025, v. 14, n. 5, p. 166, doi. 10.3390/chemosensors13050166

By:

Han, Jianying;
Van Voorhis, Wesley C.;
Quinn, Ronald J.;
Liu, Miaomiao

Publication type:

Article

Case Study: Genetic and In Silico Analysis of Familial Pancreatitis.

Published in:

Genes, 2025, v. 16, n. 5, p. 603, doi. 10.3390/genes16050603

By:

Sharma, Yash;
Good, Deborah J.

Publication type:

Article

CrypTothML: An Integrated Mixed-Solvent Molecular Dynamics Simulation and Machine Learning Approach for Cryptic Site Prediction.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4710, doi. 10.3390/ijms26104710

By:

Motono, Chie;
Yanagisawa, Keisuke;
Koseki, Jun;
Imai, Kenichiro

Publication type:

Article

Clinical Presentation and Pathophysiology of EGFRI Dermatologic Toxicities.

Published in:

Oncology (08909091), 2007, v. 21, p. 4

By:

Mitchell, Edith P.;
Perez-Soler, Roman;
Van Cutsem, Eric;
Lacouture, Mario E.

Publication type:

Article

RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 9, p. 778, doi. 10.1038/nsmb.2870

By:

Kuwasako, Kanako;
Takahashi, Mari;
Unzai, Satoru;
Tsuda, Kengo;
Yoshikawa, Seiko;
He, Fahu;
Kobayashi, Naohiro;
Güntert, Peter;
Shirouzu, Mikako;
Ito, Takuhiro;
Tanaka, Akiko;
Yokoyama, Shigeyuki;
Hagiwara, Masatoshi;
Kuroyanagi, Hidehito;
Muto, Yutaka

Publication type:

Article

Structurally encoded intraclass differences in EphA clusters drive distinct cell responses.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 8, p. 958, doi. 10.1038/nsmb.2617

By:

Seiradake, Elena;
Schaupp, Andreas;
del Toro Ruiz, Daniel;
Kaufmann, Rainer;
Mitakidis, Nikolaos;
Harlos, Karl;
Aricescu, A Radu;
Klein, Rüdiger;
Jones, E Yvonne

Publication type:

Article

Structural insights into ligand binding and gene expression control by an adenosylcobalamin riboswitch.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 11, p. 1182, doi. 10.1038/nsmb.2405

By:

Peselis, Alla;
Serganov, Alexander

Publication type:

Article

Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 10, p. 1172, doi. 10.1038/nsmb.2112

By:

Lin, Chun-Chi;
Baek, Kyuwon;
Lu, Zhe

Publication type:

Article

Tuning protein autoinhibition by domain destabilization.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 5, p. 550, doi. 10.1038/nsmb.2039

By:

Jae-Hyun Cho;
Muralidharan, Vasant;
Vila-Perello, Miquel;
Raleigh, Daniel P.;
Muir, Tom W.;
Palmer, Arthur G.

Publication type:

Article

The hidden energetics of ligand binding and activation in a glutamate receptor.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 3, p. 283, doi. 10.1038/nsmb.2010

By:

Lau, Albert Y.;
Roux, Benoît

Publication type:

Article

Structural basis of ligand binding by a c-di-GMP riboswitch.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 12, p. 1218, doi. 10.1038/nsmb.1702

By:

Smith, Kathryn D.;
Lipchock, Sarah V.;
Ames, Tyler D.;
Jimin Wang;
Breaker, Ronald R.;
Strobel, Scott A.

Publication type:

Article

Cocrystal structure of a class I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 3, p. 343, doi. 10.1038/nsmb.1563

By:

Klein, Daniel J.;
Edwards, Thomas E.;
Ferré-D'Amaré, Adrian R.

Publication type:

Article

Ligands bind to Sortilin in the tunnel of a ten-bladed β-propeller domain.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 1, p. 96, doi. 10.1038/nsmb.1543

By:

Quistgaard, Esben M.;
Madsen, Peder;
Grøftehauge, Morten K.;
Nissen, Poul;
Petersen, Claus M.;
Thirup, Søren S.

Publication type:

Article

The 'glutamate switch' provides a link between ATPase activity and ligand binding in AAA+ proteins.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 11, p. 1223, doi. 10.1038/nsmb.1501

By:

Xiaodong Zhang;
Wigley, Dale B.

Publication type:

Article

Integration of an electric-metal sensory experience in the Slo1 BK channel.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 11, p. 1130, doi. 10.1038/nsmb1108-1130

By:

Horrigan, Frank T.;
Hoshi, Toshinori

Publication type:

Article

Mapping a molecular link between allosteric inhibition and activation of the glycine receptor.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 10, p. 1084, doi. 10.1038/nsmb.1492

By:

Miller, Paul S.;
Topf, Maya;
Smart, Trevor G.

Publication type:

Article

Molecular recognition of nitrated fatty acids by PPARγ.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 8, p. 865, doi. 10.1038/nsmb.1447

By:

Li, Yong;
Zhang, Jifeng;
Schopfer, Francisco J.;
Martynowski, Dariusz;
Garcia-Barrio, Minerva T.;
Kovach, Amanda;
Suino-Powell, Kelly;
Baker, Paul R. S.;
Freeman, Bruce A.;
Chen, Y. Eugene;
Xu, H. Eric

Publication type:

Article

The structural basis for cap binding by influenza virus polymerase subunit PB2.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 5, p. 500, doi. 10.1038/nsmb.1421

By:

Guilligay, Delphine;
Tarendeau, Franck;
Resa-Infante, Patricia;
Coloma, Rocío;
Crepin, Thibaut;
Sehr, Peter;
Lewis, Joe;
Ruigrok, Rob W. H.;
Ortin, Juan;
Hart, Darren J.;
Cusack, Stephen

Publication type:

Article

Identification of heme as the ligand for the orphan nuclear receptors REV-ERBα and REV-ERBβ.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 12, p. 1207, doi. 10.1038/nsmb1344

By:

Raghuram, Srilatha;
Stayrook, Keith R.;
Huang, Pengxiang;
Rogers, Pamela M.;
Nosie, Amanda K.;
McClure, Don B.;
Burris, Lorri L.;
Khorasanizadeh, Sepideh;
Burris, Thomas P.;
Rastinejad, Fraydoon

Publication type:

Article

Structure-based design of a pathway-specific nuclear import inhibitor.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 5, p. 452, doi. 10.1038/nsmb1229

By:

Cansizoglu, Ahmet E.;
Lee, Brittany J.;
Zi Chao Zhang;
Fontoura, Beatriz M. A.;
Yuh Min Chook

Publication type:

Article

Sequence-specific dynamics modulate recognition specificity in WW domains.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 4, p. 325, doi. 10.1038/nsmb1207

By:

Peng, Tao;
Zintsmaster, John S.;
Namanja, Andrew T.;
Peng, Jeffrey W.

Publication type:

Article

Structures of the Cd44–hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 3, p. 234, doi. 10.1038/nsmb1201

By:

Banerji, Suneale;
Wright, Alan J.;
Noble, Martin;
Mahoney, David J.;
Campbell, Iain D.;
Day, Anthony J.;
Jackson, David G.

Publication type:

Article

Structural basis for autoinhibition of Notch.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 4, p. 295, doi. 10.1038/nsmb1227

By:

Gordon, Wendy R.;
Vardar-Ulu, Didem;
Histen, Gavin;
Sanchez-Irizarry, Cheryll;
Aster, Jon C.;
Blacklow, Stephen C.

Publication type:

Article

Factor B structure provides insights into activation of the central protease of the complement system.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 3, p. 224, doi. 10.1038/nsmb1210

By:

Milder, Fin J.;
Gomes, Lucio;
Schouten, Arie;
Janssen, Bert J. C.;
Huizinga, Eric G.;
Romijn, Roland A.;
Hemrika, Wieger;
Roos, Anja;
Daha, Mohamed R.;
Gros, Piet

Publication type:

Article

Transmembrane signaling by asymmetry.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 10, p. 861, doi. 10.1038/nsmb1006-862

By:

Stock, Ann M.

Publication type:

Article

Structural insights into the Notch-modifying glycosyltransferase Fringe.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 10, p. 945, doi. 10.1038/nsmb1144

By:

Jinek, Martin;
Chen, Ya-Wen;
Clausen, Henrik;
Cohen, Stephen M.;
Conti, Elena

Publication type:

Article

Dynamically driven protein allostery.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 9, p. 831, doi. 10.1038/nsmb1132

By:

Popovych, Nataliya;
Sun, Shangjin;
Ebright, Richard H.;
Kalodimos, Charalampos G.

Publication type:

Article

RNA allostery glimpsed.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 7, p. 569, doi. 10.1038/nsmb0706-569

By:

Winkler, Wade C.;
Dann III, Charles E.

Publication type:

Article

Molecular recognition of p53 and MDM2 by USP7/HAUSP.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 3, p. 285, doi. 10.1038/nsmb1067

By:

Yi Sheng;
Saridakis, Vivian;
Sarkari, Feroz;
Duan, Shili;
Tianne Wu;
Arrowsmith, Cheryl H.;
Frappier, Lori

Publication type:

Article

Structural and mechanistic determinants of c-di-GMP signalling.

Published in:

Nature Reviews Microbiology, 2009, v. 7, n. 10, p. 724, doi. 10.1038/nrmicro2203

By:

Schirmer, Tilman;
Jenal, Urs

Publication type:

Article

Bacterial physiology: OppA's deep pockets.

Published in:

Nature Reviews Microbiology, 2009, v. 7, n. 5, p. 325, doi. 10.1038/nrmicro2141

By:

van Ooij, Christiaan

Publication type:

Article

Molecular Modeling Study of the Mechanism of Ligand Binding to Human Melatonin Receptors.

Published in:

Doklady Biochemistry & Biophysics, 2005, v. 403, n. 1-6, p. 284, doi. 10.1007/s10628-005-0093-8

By:

Voronkov, A.;
Ivanov, A.;
Baskin, I.;
Palyulin, V.;
Zefirov, N.

Publication type:

Article

Molecular Modeling of the Ligand-Binding Domains of the NR3A and NR3B Subunits of the NMDA Receptor.

Published in:

Doklady Biochemistry & Biophysics, 2003, v. 389, n. 1-6, p. 83, doi. 10.1023/A:1023627904698

By:

Belenikin, M. S.;
Costantino, G.;
Palyulin, V. A.;
Pellicciari, R.;
Zefirov, N. S.

Publication type:

Article

A Quantitative Model of Ligand Binding to the Glutamate Site of the GluR2 Subunit of AMPA Receptor.

Published in:

Doklady Biochemistry & Biophysics, 2003, v. 389, n. 1-6, p. 75, doi. 10.1023/A:1023623803790

By:

Tikhonova, I. G.;
Baskin, I. I.;
Palyulin, V. A.;
Zefirov, N. S.

Publication type:

Article

Comparative Analysis of the Ligand-Binding Sites of the Metabotropic Glutamate Receptors mGluR1–mGluR8.

Published in:

Doklady Biochemistry & Biophysics, 2002, v. 386, n. 1-6, p. 251, doi. 10.1023/A:1020755427019

By:

Belenikin, M. S.;
Baskin, I. I.;
Costantino, G.;
Palyulin, V. A.;
Pellicciari, R.;
Zefirov, N. S.

Publication type:

Article

Effects of Activators and Blockers of the Ligand-Operated Cl–Channels on the Chloride Sensitivity of Microsomal Mg2+-ATPase of Bream (Abramis brama L.) Brain.

Published in:

Doklady Biochemistry & Biophysics, 2001, v. 378, n. 1-6, p. 214, doi. 10.1023/A:1011525615780

By:

Menzikov, S. A.;
Menzikova, O. V.

Publication type:

Article

Unexpected Reduction of a Coordinated Diazapyridinophane Ligand Bound to Chromium(III) Ion Leading to Delocalization of the Unpaired Electron across Two Isolated Pyridine Units.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 5, p. 1, doi. 10.1002/chem.202301099

By:

Krämer, Kristin;
Schmitz, Markus;
Kelm, Harald;
van Wüllen, Christoph;
Krüger, Hans‐Jörg

Publication type:

Article

Preclinical Evaluation of Zn(II) Self‐Assemblies with Selective Cytotoxic Activity Against Cancer Cells In Vitro and In Ovo.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 3, p. 1, doi. 10.1002/chem.202302803

By:

Allison, Simon J.;
Ashton, Gage P.;
Lynch, Hannah J.;
Shire, Bethany R.;
Phillips, Roger M.;
Parkes, Gareth M. B.;
Pinder, Emma;
Rice, Craig R.;
Teixeira, Ana A. M.;
Volleman, Tibo;
Wordsworth, Daisy A.

Publication type:

Article

One Ligand to Bind them All: S~C~S2− Carbon‐ and Sulfur‐Based Gem‐Dianion as Structuring Ligand for Iron Polymetallic Assemblies.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 58, p. 1, doi. 10.1002/chem.202302130

By:

Ravel‐Massol, Raphaël;
Munshi, Sandip;
Pujol, Anthony;
Garcia‐Serres, Ricardo;
Saffon‐Merceron, Nathalie;
Mézailles, Nicolas;
Fustier‐Boutignon, Marie

Publication type:

Article

Redox Reporter ‐ Ligand Competition to Support Signaling in the Cocaine‐Binding Electrochemical Aptamer‐Based Biosensor.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 35, p. 1, doi. 10.1002/chem.202300618

By:

Dauphin‐Ducharme, Philippe;
Churcher, Zachary R.;
Shoara, Aron A.;
Rahbarimehr, Erfan;
Slavkovic, Sladjana;
Fontaine, Nicolas;
Boisvert, Olivia;
Johnson, Philip E.

Publication type:

Article

Mechanism and Origins of Site‐Selectivity of Template‐Directed C−H Insertion of Quinolines.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 27, p. 1, doi. 10.1002/chem.202300124

By:

Fernandez, Gilberto E.;
Maiti, Debabrata;
Tantillo, Dean J.

Publication type:

Article

Surface‐Stabilized CsPbI3 Nanocrystals with Tailored Organic Polymer Ligand Binding.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 26, p. 1, doi. 10.1002/chem.202203971

By:

Liu, Xiao;
Lv, Jing;
Yao, Shunwei;
Wang, Yanan;
Peng, Lin;
Chen, Jing;
Liu, Xiaolin;
Lin, Jia;
Chen, Xianfeng

Publication type:

Article

Site‐Specific Labeling of RNAs with Modified and 19F‐Labeled Nucleotides by Chemo‐Enzymatic Synthesis.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 25, p. 1, doi. 10.1002/chem.202203368

By:

Sudakov, Alexey;
Knezic, Bozana;
Hengesbach, Martin;
Fürtig, Boris;
Stirnal, Elke;
Schwalbe, Harald

Publication type:

Article

Synthesis and Characterization of a Masked Terminal Nickel‐Oxide Complex.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 21, p. 1, doi. 10.1002/chem.202203840

By:

Heim, Philipp;
Spedalotto, Giuseppe;
Lovisari, Marta;
Gericke, Robert;
O'Brien, John;
Farquhar, Erik R.;
McDonald, Aidan R.

Publication type:

Article

Using Macrocyclic G‐Quadruplex Ligands to Decipher the Interactions Between Small Molecules and G‐Quadruplex DNA.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 65, p. 1, doi. 10.1002/chem.202202020

By:

Andréasson, Måns;
Bhuma, Naresh;
Pemberton, Nils;
Chorell, Erik

Publication type:

Article

Mechanistic and Kinetic Investigations of ON/OFF (Photo)Switchable Binding of Carbon Monoxide by Chromium(0), Molybdenum(0) and Tungsten(0) Carbonyl Complexes with a Pyridyl‐Mesoionic Carbene Ligand.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 51, p. 1, doi. 10.1002/chem.202201038

By:

Boden, Pit J.;
Di Martino‐Fumo, Patrick;
Bens, Tobias;
Steiger, Sophie T.;
Marhöfer, Daniel;
Niedner‐Schatteburg, Gereon;
Sarkar, Biprajit

Publication type:

Article

Photoswitching Affinity and Mechanism of Multivalent Lectin Ligands.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 27, p. 1, doi. 10.1002/chem.202200267

By:

Osswald, Uwe;
Boneberg, Johannes;
Wittmann, Valentin

Publication type:

Article

Characterizing Enzyme Cooperativity with Imaging SAMDI‐MS.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 12, p. 1, doi. 10.1002/chem.202103807

By:

Grant, Jennifer;
Kimmel, Blaise R.;
Szymczak, Lindsey C.;
Roll, Juliet;
Mrksich, Milan

Publication type:

Article

Indoloquinoline Ligands Favor Intercalation at Quadruplex‐Duplex Interfaces.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 7, p. 1, doi. 10.1002/chem.202103718

By:

Vianney, Yoanes Maria;
Weisz, Klaus

Publication type:

Article