Works matching AU Flatt, Peter R.

Results: 122

Insulinotropic, glucose-lowering, and beta-cell anti-apoptotic actions of peptides related to esculentin-1a(1-21).NH2.

Published in:

Amino Acids, 2018, v. 50, n. 6, p. 723, doi. 10.1007/s00726-018-2551-5

By:

Musale, Vishal;
Abdel-Wahab, Yasser H. A.;
Flatt, Peter R.;
Conlon, J. Michael;
Mangoni, Maria Luisa

Publication type:

Article

Identification of Multiple Pancreatic and Extra-Pancreatic Pathways Underlying the Glucose-Lowering Actions of Acacia arabica Bark in Type-2 Diabetes and Isolation of Active Phytoconstituents.

Published in:

Plants (2223-7747), 2021, v. 10, n. 6, p. 1190, doi. 10.3390/plants10061190

By:

Ansari, Prawej;
Flatt, Peter R.;
Harriott, Patrick;
Hannan, J. M. A.;
Abdel-Wahab, Yasser H. A.

Publication type:

Article

Evaluation of the Antidiabetic and Insulin Releasing Effects of A. squamosa, Including Isolation and Characterization of Active Phytochemicals.

Published in:

Plants (2223-7747), 2020, v. 9, n. 10, p. 1348, doi. 10.3390/plants9101348

By:

Ansari, Prawej;
Flatt, Peter R.;
Harriott, Patrick;
Abdel-Wahab, Yasser H.A.

Publication type:

Article

Cafeteria diet compromises natural adaptations of islet cell transdifferentiation and turnover in pregnancy.

Published in:

Diabetic Medicine, 2025, v. 42, n. 1, p. 1, doi. 10.1111/dme.15434

By:

Dubey, Vaibhav;
Tanday, Neil;
Irwin, Nigel;
Tarasov, Andrei I.;
Flatt, Peter R.;
Moffett, R. Charlotte

Publication type:

Article

Vincent Marks (10 June 1930 to 6 November 2023).

Published in:

2024

By:

Flatt, Peter R.;
Bailey, Clifford J.

Publication type:

Obituary

Amplifying the antidiabetic actions of glucagon‐like peptide‐1: Potential benefits of new adjunct therapies.

Published in:

Diabetic Medicine, 2021, v. 38, n. 12, p. 1, doi. 10.1111/dme.14699

By:

Tanday, Neil;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Editorial: Proglucagon-Derived Peptides.

Published in:

Frontiers in Endocrinology, 2021, v. 12, p. 1, doi. 10.3389/fendo.2021.776871

By:

Flatt, Peter R.;
Knop, Filip K.;
Tarasov, Andrei I.

Publication type:

Article

Proglucagon-Derived Peptides as Therapeutics.

Published in:

Frontiers in Endocrinology, 2021, v. 11, p. N.PAG, doi. 10.3389/fendo.2021.689678

By:

Lafferty, Ryan A.;
O'Harte, Finbarr P. M.;
Irwin, Nigel;
Gault, Victor A.;
Flatt, Peter R.

Publication type:

Article

Benefits of Sustained Upregulated Unimolecular GLP-1 and CCK Receptor Signalling in Obesity-Diabetes.

Published in:

Frontiers in Endocrinology, 2021, v. 11, p. N.PAG, doi. 10.3389/fendo.2021.674704

By:

Tanday, Neil;
English, Andrew;
Lafferty, Ryan A.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice.

Published in:

Frontiers in Endocrinology, 2021, v. 11, p. N.PAG, doi. 10.3389/fendo.2021.633625

By:

Lafferty, Ryan A.;
Tanday, Neil;
Moffett, R. Charlotte;
Reimann, Frank;
Gribble, Fiona M.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Plant-Based Diets and Phytochemicals in the Management of Diabetes Mellitus and Prevention of Its Complications: A Review.

Published in:

Nutrients, 2024, v. 16, n. 21, p. 3709, doi. 10.3390/nu16213709

By:

Ansari, Prawej;
Khan, Joyeeta T.;
Chowdhury, Suraiya;
Reberio, Alexa D.;
Kumar, Sandeep;
Seidel, Veronique;
Abdel-Wahab, Yasser H. A.;
Flatt, Peter R.

Publication type:

Article

Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice.

Published in:

PLoS ONE, 2018, v. 13, n. 8, p. 1, doi. 10.1371/journal.pone.0202350

By:

O’Harte, Finbarr P. M.;
Parthsarathy, Vadivel;
Hogg, Christopher;
Flatt, Peter R.

Publication type:

Article

The Beneficial Impact of a Novel Pancreatic Polypeptide Analogue on Islet Cell Lineage.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 9, p. 4215, doi. 10.3390/ijms26094215

By:

Zhu, Wuyun;
Tanday, Neil;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Nutrient regulation of the entero-insular axis and insulin secretion

Published in:

Nutrition Research Reviews, 1988, v. 1, p. 79

By:

Flatt, Peter R.;
Morgan, Linda M.;
Marks, Vincent

Publication type:

Article

[P3]PP, a stable, long‐acting pancreatic polypeptide analogue, evokes weight lowering and pancreatic beta‐cell‐protective effects in obesity‐associated diabetes.

Published in:

Diabetes, Obesity & Metabolism, 2024, v. 26, n. 11, p. 4945, doi. 10.1111/dom.15897

By:

Tanday, Neil;
Zhu, Wuyun;
Tarasov, Andrei I.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Pancreatic islet cell plasticity: Pathogenic or therapeutically exploitable?

Published in:

Diabetes, Obesity & Metabolism, 2024, v. 26, n. 1, p. 16, doi. 10.1111/dom.15300

By:

Tanday, Neil;
Tarasov, Andrei I.;
Moffett, R. Charlotte;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Beneficial metabolic effects of recurrent periods of beta‐cell rest and stimulation using stable neuropeptide Y1 and glucagon‐like peptide‐1 receptor agonists.

Published in:

Diabetes, Obesity & Metabolism, 2022, v. 24, n. 12, p. 2353, doi. 10.1111/dom.14821

By:

Tanday, Neil;
Lafferty, Ryan A.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Weight‐reducing, lipid‐lowering and antidiabetic activities of a novel arginine vasopressin analogue acting at the V1a and V1b receptors in high‐fat‐fed mice.

Published in:

Diabetes, Obesity & Metabolism, 2021, v. 23, n. 10, p. 2215, doi. 10.1111/dom.14462

By:

Mohan, Shruti;
Flatt, Peter R.;
Irwin, Nigel;
Moffett, R. Charlotte

Publication type:

Article

Beneficial actions of a long‐acting apelin analogue in diabetes are related to positive effects on islet cell turnover and transdifferentiation.

Published in:

Diabetes, Obesity & Metabolism, 2020, v. 22, n. 12, p. 2468, doi. 10.1111/dom.14177

By:

Tanday, Neil;
Irwin, Nigel;
Moffett, R. Charlotte;
Flatt, Peter R.;
O'Harte, Finbarr P. M.

Publication type:

Article

Role of exendin‐4 in the Gila monster: Further lessons regarding human oral glucagon‐like peptide‐1 therapy?

Published in:

Diabetes, Obesity & Metabolism, 2020, v. 22, n. 12, p. 2509, doi. 10.1111/dom.14171

By:

Graham, Galyna V.;
McLaughlin, Chris M.;
Flatt, Peter R.

Publication type:

Article

Peptide YY (1–36) peptides from phylogenetically ancient fish targeting mammalian neuropeptide Y1 receptors demonstrate potent effects on pancreatic β‐cell function, growth and survival.

Published in:

Diabetes, Obesity & Metabolism, 2020, v. 22, n. 3, p. 404, doi. 10.1111/dom.13908

By:

Lafferty, Ryan A.;
Tanday, Neil;
McCloskey, Andrew;
Bompada, Pradeep;
De Marinis, Yang;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Effects of long-acting analogues of lamprey GLP-1 and paddlefish glucagon on alpha- to beta-cell transdifferentiation in an insulin-deficient transgenic mouse model.

Published in:

Journal of Peptide Science, 2021, v. 27, n. 8, p. 1, doi. 10.1002/psc.3328

By:

Graham, Galyna V.;
Conlon, J. Michael;
Moffett, R. Charlotte;
Abdel-Wahab, Yasser H.;
Flatt, Peter R.

Publication type:

Article

Assessment of the potential of temporin peptides from the frog Rana temporaria (Ranidae) as anti-diabetic agents.

Published in:

Journal of Peptide Science, 2018, v. 24, n. 2, p. 1, doi. 10.1002/psc.3065

By:

Musale, Vishal;
Casciaro, Bruno;
Mangoni, Maria Luisa;
Abdel‐Wahab, Yasser H.A.;
Flatt, Peter R.;
Conlon, J. Michael

Publication type:

Article

Cytotoxic peptides with insulin-releasing activities from skin secretions of the Italian stream frog Rana italica (Ranidae).

Published in:

Journal of Peptide Science, 2017, v. 23, n. 10, p. 769, doi. 10.1002/psc.3025

By:

Conlon, J. Michael;
Musale, Vishal;
Attoub, Samir;
Mangoni, Maria Luisa;
Leprince, Jérôme;
Coquet, Laurent;
Jouenne, Thierry;
Abdel ‐ Wahab, Yasser H. A.;
Flatt, Peter R.;
Rinaldi, Andrea C.

Publication type:

Article

Comparison of the subchronic antidiabetic effects of DPP IV-resistant GIP and GLP-1 analogues in obese diabetic ( ob/ob) mice.

Published in:

Journal of Peptide Science, 2007, v. 13, n. 6, p. 400, doi. 10.1002/psc.861

By:

Irwin, Nigel;
McClean, Paula L.;
Flatt, Peter R.

Publication type:

Article

Effects of 2 Novel PYY(1-36) Analogues, (P 3 L 31 P 34)PYY(1-36) and PYY(1-36)(Lys 12 PAL), on Pancreatic Beta-Cell Function, Growth, and Survival.

Published in:

Clinical Medicine Insights: Endocrinology & Diabetes, 2019, v. 12, p. N.PAG, doi. 10.1177/1179551419855626

By:

Lafferty, Ryan A;
Gault, Victor A;
Flatt, Peter R;
Irwin, Nigel

Publication type:

Article

Effects of 2 Novel PYY(1-36) Analogues, (P 3 L 31 P 34)PYY(1-36) and PYY(1-36)(Lys 12 PAL), on Pancreatic Beta-Cell Function, Growth, and Survival.

Published in:

Clinical Medicine Insights: Endocrinology & Diabetes, 2019, v. 12, p. N.PAG, doi. 10.1177/1179551419855626

By:

Lafferty, Ryan A;
Gault, Victor A;
Flatt, Peter R;
Irwin, Nigel

Publication type:

Article

Role of Endogenous GLP-1 and GIP in Beta Cell Compensatory Responses to Insulin Resistance and Cellular Stress.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0101005

By:

Vasu, Srividya;
Moffett, R. Charlotte;
Thorens, Bernard;
Flatt, Peter R.

Publication type:

Article

Incretin Receptor Null Mice Reveal Key Role of GLP-1 but Not GIP in Pancreatic Beta Cell Adaptation to Pregnancy.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0096863

By:

Moffett, R. Charlotte;
Vasu, Srividya;
Thorens, Bernard;
Drucker, Daniel J.;
Flatt, Peter R.

Publication type:

Article

Alterations of Glucose-Dependent Insulinotropic Polypeptide and Expression of Genes Involved in Mammary Gland and Adipose Tissue Lipid Metabolism during Pregnancy and Lactation.

Published in:

PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0078560

By:

Moffett, R. Charlotte;
Irwin, Nigel;
Francis, Jacqueline M. E.;
Flatt, Peter R.

Publication type:

Article

Effective surgical treatment of obesity may be mediated by ablation of the lipogenic gut hormone gastric inhibitory polypeptide (GIP): evidence and clinical opportunity for development of new obesity-diabetes drugs?

Published in:

Diabetes & Vascular Disease Research, 2007, v. 4, n. 2, p. 150, doi. 10.3132/dvdr.2007.034

By:

Flatt, Peter R

Publication type:

Article

Dipeptidyl peptidase IV (DPP IV) inhibitors: a newly emerging drug class for the treatment of type 2 diabetes.

Published in:

Diabetes & Vascular Disease Research, 2006, v. 3, n. 3, p. 159, doi. 10.3132/dvdr.2006.024

By:

Green, Brian D;
Flatt, Peter R;
Bailey, Clifford J

Publication type:

Article

Insulinotropic Actions of the Frog Skin Host-Defense Peptide Alyteserin-2a: A Structure-Activity Study.

Published in:

Chemical Biology & Drug Design, 2013, v. 82, n. 2, p. 196, doi. 10.1111/cbdd.12151

By:

Ojo, Opeolu O.;
Abdel ‐ Wahab, Yasser H. A.;
Flatt, Peter R.;
Conlon, J. Michael

Publication type:

Article

Demonstration of glycated insulin in human diabetic plasma and decreased biological activity assessed by euglycemic-hyperinsulinemic clamp technique in humans.

Published in:

2003

By:

Hunter, Steven J.;
Boyd, Alison C.;
O'Harte, Finbarr P. M.;
McKillop, Aine M.;
Wiggam, M. Ivan;
Mooney, Mark H.;
McCluskey, Jane T.;
Lindsay, John R.;
Ennis, Cieran N.;
Gamble, Raymond;
Sheridan, Brian;
Barnett, Christopher R.;
McNulty, Helene;
Bell, Patrick M.;
Flatt, Peter R.

Publication type:

journal article

A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine is important to the regulation of insulin secretion.

Published in:

2002

By:

Brennan, Lorraine;
Shine, Aine;
Hewage, Chandralal;
G. Malthouse, J. Paul;
Brindle, Kevin M.;
McClenaghan, Neville;
Flatt, Peter R.;
Newsholme, Philip;
Malthouse, J Paul G

Publication type:

journal article

Overexpression of the Na/Ca exchanger shapes stimulus-induced cytosolic Ca(2+) oscillations in insulin-producing BRIN-BD11 cells.

Published in:

2002

By:

Van Eylen, Françoise;
Horta, Oscar Diaz;
Barez, Aurore;
Kamagate, Adama;
Flatt, Peter R;
Macianskiene, Regina;
Mubagwa, Kanigula;
Herchuelz, André

Publication type:

journal article

Overexpression of the Na/Ca Exchanger Shapes Stimulus-Induced Cytosolic Ca2+; Oscillations in Insulin-Producing BRIN-BD11 Cells.

Published in:

Diabetes, 2002, v. 51, n. 2, p. 367, doi. 10.2337/diabetes.51.2.366

By:

Van Eylen, Françoise;
Horta, Oscar Diaz;
Barez, Aurore;
Kamagate, Adama;
Flatt, Peter R.;
Macianskiene, Regina;
Mubagwa, Kanigula;
Herchuelz, André

Publication type:

Article

ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 beta-cell line.

Published in:

1999

By:

Chapman, Joanna C.;
McClenaghan, Neville H.;
Cosgrove, Karen E.;
Hashmi, Molly N.;
Shepherd, Ruth M.;
Giesberts, Aukje N.;
White, Stanley J.;
Ammala, Carina;
Flatt, Peter R.;
Dunne, Mark J.;
Chapman, J C;
McClenaghan, N H;
Cosgrove, K E;
Hashmi, M N;
Shepherd, R M;
Giesberts, A N;
White, S J;
Ammälä, C;
Flatt, P R;
Dunne, M J

Publication type:

journal article

NH[sub 2]-terminally modified gastric inhibitory polypeptide exhibits amino-peptidase resistance and enhanced antihyperglycemic activity.

Published in:

Diabetes, 1999, v. 48, n. 4, p. 758, doi. 10.2337/diabetes.48.4.758

By:

P.M. O'Harte, Finbarr;
Mooney, Mark H.;
Flatt, Peter R.

Publication type:

Article

Glycated cholecystokinin-8 has an enhanced satiating activity and is protected against enzymatic degradation.

Published in:

1998

By:

O'Harte, Finbarr P.M.;
Mooney, Mark H.;
Kelly, Catherine M.N.;
Flatt, Peter R.;
O'Harte, F P;
Mooney, M H;
Kelly, C M;
Flatt, P R

Publication type:

journal article

Glycation of insulin in the islets of Langerhans of normal and diabetic animals.

Published in:

1996

By:

Abdel-Wahab, Yasser H. A.;
O'Harte, Finbarr P. M.;
Ratcliff, Helen;
McClenaghan, Neville H.;
Barnett, Christopher R.;
Flatt, Peter R.;
Abdel-Wahab, Y H;
O'Harte, F P;
Ratcliff, H;
McClenaghan, N H;
Barnett, C R;
Flatt, P R

Publication type:

journal article

Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion.

Published in:

1996

By:

McClenaghan, Neville H.;
Barnett, Christopher R.;
Ah-Sing, Eric;
Abdel-Wahab, Yasser H. A.;
O'Harte, Finbarr P. M.;
Tai-Wook Yoon;
Swanston-Flatt, Sara K.;
Flatt, Peter R.;
McClenaghan, N H;
Barnett, C R;
Ah-Sing, E;
Abdel-Wahab, Y H;
O'Harte, F P;
Yoon, T W;
Swanston-Flatt, S K;
Flatt, P R

Publication type:

journal article

Abnormalities of GIP in spontaneous syndromes of obesity and diabetes in mice.

Published in:

1983

By:

Flatt, Peter R.;
Bailey, Clifford J.;
Kwasowski, Peter;
Swanston-Flatt, Sara K.;
Marks, Vincent;
Flatt, P R;
Bailey, C J;
Kwasowski, P;
Swanston-Flatt, S K;
Marks, V

Publication type:

journal article

A stable analogue of glucose-dependent insulinotropic polypeptide, GIP(LysPAL16), enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones.

Published in:

Biological Chemistry, 2006, v. 387, n. 7, p. 941, doi. 10.1515/BC.2006.118

By:

Marenah, Lamin;
McCluskey, Jane T.;
Abdel-Wahab, Yasser H. A.;
O'Harte, Finbarr P. M.;
McClenaghan, Neville H.;
Flatt, Peter R.

Publication type:

Article

Antidiabetic potential of two novel fatty acid derivatised, N-terminally modified analogues of glucose-dependent insulinotropic polypeptide (GIP): N-AcGIP(LysPAL16) and N-AcGIP(LysPAL37).

Published in:

Biological Chemistry, 2005, v. 386, n. 7, p. 679, doi. 10.1515/BC.2005.079

By:

Irwin, Nigel;
Gault, Victor A.;
Green, Brian D.;
Greer, Brett;
Harriott, Patrick;
Bailey, Clifford J.;
Flatt, Peter R.;
O'Harte, Finbarr P.M.

Publication type:

Article

Isolation and structural characterisation of a novel 13-amino acid insulin-releasing peptide from the skin secretion of Agalychnis calcarifer.

Published in:

Biological Chemistry, 2005, v. 386, n. 6, p. 581, doi. 10.1515/BC.2005.068

By:

Abdel-Wahab, Yasser H. A.;
Marenah, Lamin;
Orr, David F.;
Shaw, Chris;
Flatt, Peter R.

Publication type:

Article

Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice.

Published in:

Biological Chemistry, 2004, v. 385, n. 9, p. 845, doi. 10.1515/BC.2004.110

By:

Irwin, Nigel;
Gault, Victor A.;
Green, Brian D.;
Greer, Brett;
McCluskey, Jane T.;
Harriott, Patrick;
O'Harte, Finbarr P. M.;
Flatt, Peter R.

Publication type:

Article

Skin secretion of the toad Bombina variegata contains multiple insulin-releasing peptides including bombesin and entirely novel insulinotropic structures.

Published in:

Biological Chemistry, 2004, v. 385, n. 3/4, p. 315, doi. 10.1515/BC.2004.027

By:

Marenah, Lamin;
Flatt, Peter R.;
Orr, David F.;
McClean, Steven;
Shaw, Chris;
Abdel-Wahab, Yasser H. A.

Publication type:

Article

Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala8 -substituted GLP-1 analogues.

Published in:

Biological Chemistry, 2004, v. 385, n. 2, p. 169, doi. 10.1515/BC.2004.035

By:

Green, Brian D.;
Gault, Victor A.;
Mooney, Mark H.;
Irwin, Nigel;
Harriott, Patrick;
Greer, Brett;
Bailey, Cliff J.;
O'Harte, Finbarr P. M.;
Flatt, Peter R.

Publication type:

Article

Metabolic Stability, Receptor Binding, cAMP Generation, Insulin Secretion and Antihyperglycaemic Activity of Novel N-Terminal Glu[sup9] -Substituted Analogues of Glucagon-Like Peptide-1.

Published in:

Biological Chemistry, 2003, v. 384, n. 12, p. 1543, doi. 10.1515/BC.2003.171

By:

Green, Brian D.;
Gault, Victor A.;
Irwin, Nigel;
Mooney, Mark H.;
Bailey, Clifford J.;
Harriott, Patrick;
Greer, Brett;
Flatt, Peter R.;
O'Harte, Finbarr P. M.

Publication type:

Article