Results
Title

The role of hyperthermia as a treatment for non-muscle invasive bladder cancer.

Authors

Bahouth, Zaher; Halachmi, Sarel; Moskovitz, Boaz; Nativ, Ofer

Abstract

Non-muscle invasive bladder cancer (NMIBC) has a high tendency for recurrence and progression. Currently, all known intravesical agents are associated with adverse effects (AEs) and limited efficacy. The combination of hyperthermia (HT) with intravesical Mitomycin C (MMC) chemotherapy has been shown to improve outcomes. The added efficacy of HT to MMC was first shown in preclinical studies. The reports on patients with NMIBC have indicated that the treatment is safe and well tolerated. Several clinical studies reported the efficacy of radiofrequency-induced chemotherapy effect (RITE) in the treatment of patients with NMIBC. This modality was shown to be superior to MMC alone. RITE was effective also in patients with high-risk NMIBC, including those who failed Bacillus Calmette-Guérin (BCG). This study provides an updated review of literature regarding the use of RITE in patients with NMIBC.

Subjects

ANIMAL experimentation; ANTINEOPLASTIC antibiotics; BLADDER tumors; COMBINED modality therapy; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; RESEARCH; THERMOTHERAPY; EVALUATION research; TREATMENT effectiveness; INTRAVESICAL administration; MITOMYCINS; TUMOR treatment; THERAPEUTICS

Publication

Expert Review of Anticancer Therapy, 2016, Vol 16, Issue 2, p189

ISSN

1473-7140

Publication type

Academic Journal

DOI

10.1586/14737140.2016.1126515