Results
Title

UTILIZATION OF MICROWAVE ASSISTED BLACK CUMIN SEED EXTRACT AS HYPOCHOLESTEROLEMIC AGENT IN ALBINO RATS.

Authors

Khalil, Anees Ahmed; Khalid, Ahood; Khalid, Hira; Aslam, Ayesha; Shahid, Quratul Ain; Hlebová, Miroslava; Rebezov, Maksim; Derkho, Marina; Shariati, Mohammad Ali

Abstract

Main aim of this study was to evaluate hypocholesterolemic potential of microwave-assisted black cumin (Nigella sativa) extracts (MABCEs) in a rat bioassay. Efficacy trial in this study comprised of 25 male albino rats which were divided into 5 groups having 5 rats each. Out of these 25 rats, 20 were hypercholesterolemic and 5 were normal rats. Hypercholesterolemia was induced by providing high cholesterol diet for 15 days, and after the onset of hypercholesterolemia these rats were administered with different concentrations of the MABCE i.e. 150, 300 & 450 mg/kg B.W. for a period of 28 days. The administration of extract displayed significant lowering in the lipid profile of the experimental rats. The 300mg/kg B.W. dose of black cumin MAE provided the optimum results giving cholesterol, triglyceride and LDL-c content lowered by 14.9%, 11.32% and 12% and value of HDL-c elevated by 12.88% compared to the hypercholesterolemic control. Similarly, there was a percent elevation in levels of SOD and CAT by 19.83% and 13.97%. The current study concluded that MABCEs have hypocholesterolemic effect thus can be used for its therapeutic property.

Subjects

BLACK cumin; HIGH cholesterol diet; RATS; ALBINISM; MICROWAVES

Publication

Journal of Microbiology, Biotechnology & Food Sciences, 2021, Vol 10, Issue 4, p536

ISSN

1338-5178

Publication type

Academic Journal

DOI

10.15414/jmbfs.2021.10.4.536-540