Title: Cornering the Fear Engram: Long-Term Synaptic Changes in the Lateral Nucleus of the Amygdala after Fear Conditioning.
Authors: Jeong-Tae Kwon; June-Seek Choi
Abstract: Use-dependent synaptic modifications in the lateral nucleus of the amygdala (LA) have been suggested to be the cellular analog of memory trace after pavlovian fear conditioning. However, whether neurophysiological changes in the LA are produced as a direct consequence of associative learning awaits additional proof. Using microstimulation of the medial geniculate nucleus of the thalamus as the conditioned stimulus (CS), we demonstrated that contingent pairings of the brain-stimulation CS and a footshock unconditioned stimulus lead to enhanced synaptic efficacy in the thalamic input to the LA, supporting the hypothesis that localized synaptic alterations underlie fear memory formation.
Subjects: NERVE tissue proteins; CLASSICAL conditioning; AMYGDALOID body; BRAIN stimulation; NEUROPHYSIOLOGY; NEUROSCIENCES
Publication: Journal of Neuroscience, 2009, Vol 29, Issue 31, p9700
ISSN: 0270-6474
Publication type: Academic Journal
DOI: 10.1523/JNEUROSCI.5928-08.2009

Cornering the Fear Engram: Long-Term Synaptic Changes in the Lateral Nucleus of the Amygdala after Fear Conditioning.

Jeong-Tae Kwon; June-Seek Choi