Noradrenergic Activity in the Olfactory Bulb Is a Key Element for the Stability of Olfactory Memory.

Linster, Christiane; Midroit, Maellie; Forest, Jeremy; Thenaisie, Yohann; Christina Cho; Richard, Marion; Didier, Anne; Mandairon, Nathalie

Memory stability is essential for animal survival when environment and behavioral state change over short or long time spans. The stability of a memory can be expressed by its duration, its perseverance when conditions change as well as its specificity to the learned stimulus. Using optogenetic and pharmacological manipulations in male mice, we show that the presence of noradrenaline in the olfactory bulb during acquisition renders olfactory memories more stable. We show that while inhibition of noradrenaline transmission during an odor-reward acquisition has no acute effects, it alters perseverance, duration, and specificity of the memory. We use a computational approach to propose a proof of concept model showing that a single, simple network effect of noradrenaline on olfactory bulb dynamics can underlie these seemingly different behavioral effects. Our results show that acute changes in network dynamics can have long-term effects that extend beyond the network that was manipulated.

OLFACTORY bulb; BEHAVIOR; MEMORY; SMELL; NETWORK effect; PROOF of concept

Journal of Neuroscience, 2020, Vol 40, Issue 48, p9260

0270-6474

Academic Journal

10.1523/JNEUROSCI.1769-20.2020