Works matching DE "SECRETASE inhibitors"
Results: 230
Computational exploration and experimental validation to identify a dual inhibitor of cholinesterase and amyloid-beta for the treatment of Alzheimer's disease.
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- Journal of Computer-Aided Molecular Design, 2020, v. 34, n. 9, p. 983, doi. 10.1007/s10822-020-00318-w
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- Article
D3R Grand Challenge 4: ligand similarity and MM-GBSA-based pose prediction and affinity ranking for BACE-1 inhibitors.
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- Journal of Computer-Aided Molecular Design, 2020, v. 34, n. 2, p. 163, doi. 10.1007/s10822-019-00249-1
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- Article
The protein–surfactant stoichiometry governs the conformational switching and amyloid nucleation kinetics of tau K18.
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- European Biophysics Journal, 2020, v. 49, n. 6, p. 425, doi. 10.1007/s00249-020-01447-8
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- Article
The Effect of Terpenoids of Dipsacus Asperoides Against Alzheimer’s Disease and Development of Simultaneous Analysis by High Performance Liquid Chromatography.
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- Natural Product Communications, 2021, v. 16, n. 9, p. 1, doi. 10.1177/1934578X211044603
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- Article
Computer-assisted evaluation of plant-derived β-secretase inhibitors in Alzheimer's disease.
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- Egyptian Journal of Medical Human Genetics, 2021, v. 22, n. 1, p. 1, doi. 10.1186/s43042-021-00150-3
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- Article
Molecular Integrative Analysis of the Inhibitory Effects of Dipeptides on Amyloid β Peptide 1–42 Polymerization.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 8, p. 7673, doi. 10.3390/ijms24087673
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- Article
Gamma Secretase Inhibitors as Potential Therapeutic Targets for Notch Signaling in Uterine Leiomyosarcoma.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 11, p. 5980, doi. 10.3390/ijms23115980
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- Article
Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 20, p. 7652, doi. 10.3390/ijms21207652
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- Article
Copper Coordination Compounds as Biologically Active Agents.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 11, p. 3965, doi. 10.3390/ijms21113965
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- Article
Polyphenols with Anti-Amyloid β Aggregation Show Potential Risk of Toxicity Via Pro-Oxidant Properties.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 10, p. 3561, doi. 10.3390/ijms21103561
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- Article
Prevention of Cognitive Decline in Alzheimer's Disease by Novel Antioxidative Supplements.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 6, p. 1974, doi. 10.3390/ijms21061974
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- Article
A β-Secretase (BACE1)-inhibiting C-Methylrotenoid Induced by Yeast Elicitation in Abronia nana Suspension Cultures.
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- Applied Biochemistry & Biotechnology, 2014, v. 172, n. 7, p. 3529, doi. 10.1007/s12010-014-0762-0
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- Article
Herbal Mixture of Carthamus tinctorius L. Seed and Taraxacum coreanum Attenuates Amyloid Beta-Induced Cognitive Dysfunction In Vivo.
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- Foods, 2022, v. 11, n. 2, p. 142, doi. 10.3390/foods11020142
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- Article
Systematic Evaluation for the Influences of the SOX17/Notch Receptor Family Members on Reversing Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cells.
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- Frontiers in Oncology, 2021, v. 11, p. N.PAG, doi. 10.3389/fonc.2021.607291
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- Article
Regulation of osteoprotegerin expression by Notch signaling in human oral squamous cell carcinoma cell line.
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- Asian Pacific Journal of Tropical Biomedicine, 2016, v. 6, n. 8, p. 692, doi. 10.1016/j.apjtb.2016.06.012
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- Article
The Role of Pharmacotherapeutic Agents in Children with Desmoid Tumors.
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- Pediatric Drugs, 2022, v. 24, n. 5, p. 433, doi. 10.1007/s40272-022-00526-x
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- Article
Why Is Tetradentate Coordination Essential for Potential Copper Homeostasis Regulators in Alzheimer's Disease?
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- European Journal of Inorganic Chemistry, 2019, v. 2019, n. 44, p. 4712, doi. 10.1002/ejic.201900951
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- Article
Haloperidol inhibits Memapsin 2: Innovation by docking simulation and in vitro assay.
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- Pakistan Journal of Pharmaceutical Sciences, 2015, v. 28, n. 1, p. 139
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- Article
Combined Treatment with a BACE Inhibitor and Anti-Aβ Antibody Gantenerumab Enhances Amyloid Reduction in APP<sub>London</sub> Mice.
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- Journal of Neuroscience, 2014, v. 34, n. 35, p. 11621, doi. 10.1523/JNEUROSCI.1405-14.2014
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- Article
Genetic Modulation of Soluble Aβ Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease.
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- Journal of Neuroscience, 2014, v. 34, n. 23, p. 7871, doi. 10.1523/JNEUROSCI.0572-14.2014
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- Article
Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease.
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- Journal of Neuroscience, 2014, v. 34, n. 11, p. 3826, doi. 10.1523/JNEUROSCI.5171-13.2014
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- Article
γ-Secretase inhibitor enhances antitumour effect of radiation in Notch-expressing lung cancer.
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- British Journal of Cancer, 2012, v. 106, n. 12, p. 1953, doi. 10.1038/bjc.2012.178
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- Article
Notch signalling pathway as an oncogenic factor involved in cancer development.
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- Contemporary Oncology / Współczesna Onkologia, 2016, v. 20, n. 4, p. 267, doi. 10.5114/wo.2016.61845
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- Article
Strong therapeutic potential of γ-secretase inhibitor MRK003 for CD44-high and CD133-low glioblastoma initiating cells.
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- Journal of Neuro-Oncology, 2015, v. 121, n. 2, p. 239, doi. 10.1007/s11060-014-1630-z
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- Article
Synthesis of carbon-14 and stable isotope labeled Avagacestat: a novel gamma secretase inhibitor for the treatment of Alzheimer's disease.
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- Journal of Labelled Compounds & Radiopharmaceuticals, 2014, v. 57, n. 10, p. 600, doi. 10.1002/jlcr.3224
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Auditory system: turn it up a notch.
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- 2013
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- journal article
Expression of Amyloid Precursor Protein, Caveolin-1, Alpha-, Beta-, and Gamma-Secretases in Penumbra Cells after Photothrombotic Stroke and Evaluation of Neuroprotective Effect of Secretase and Caveolin-1 Inhibitors.
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- Biomedicines, 2022, v. 10, n. 10, p. N.PAG, doi. 10.3390/biomedicines10102655
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- Article
Super-resolution microscopy reveals γ- secretase at both sides of the neuronal synapse.
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- Acta Neuropathologica Communications, 2016, v. 4, p. 1, doi. 10.1186/s40478-016-0296-5
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- Article
Natural coumarins from Murraya paniculata as mixed-type inhibitors of cholinesterases: In vitro and in silico investigations.
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- Frontiers in Pharmacology, 2023, v. 14, p. 01, doi. 10.3389/fphar.2023.1133809
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- Article
2-Mercaptobenzimidazole clubbed hydrazone for Alzheimer's therapy: In vitro, kinetic, in silico, and in vivo potentials.
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- Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.946134
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- Article
Tuning Functional Amyloid Formation Through Disulfide Engineering.
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- Frontiers in Microbiology, 2020, v. 11, p. 1, doi. 10.3389/fmicb.2020.00944
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- Article
Current Research in Neuropathology and Pharmacotherapy of Alzheimer’s Disease: A Review.
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- Indian Journal of Public Health Research & Development, 2020, v. 11, n. 2, p. 427, doi. 10.37506/v11/i2/2020/ijphrd/194838
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- Article
Current Research in Neuropathology and Pharmacotherapy of Alzheimer’s Disease: A Review.
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- Indian Journal of Public Health Research & Development, 2020, v. 11, n. 1, p. 334, doi. 10.37506/v11/i1/2020/ijphrd/193840
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- Article
Anthraquinones extracted from Rubia cordifolia Linn as potential ligands to treat Alzheimer's disease.
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- Thai Journal of Pharmaceutical Sciences, 2021, v. 45, n. 3, p. 178
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- Article
Evaluating Potential QT Effects of JNJ‐54861911, a BACE Inhibitor in Single‐ and Multiple‐Ascending Dose Studies, and a Thorough QT Trial With Additional Retrospective Confirmation, Using Concentration‐QTc Analysis.
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- Journal of Clinical Pharmacology, 2018, v. 58, n. 7, p. 952, doi. 10.1002/jcph.1087
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- Article
ACU193: An Immunotherapeutic Poised to Test the Amyloid β Oligomer Hypothesis of Alzheimer's Disease.
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- Frontiers in Neuroscience, 2022, p. 1, doi. 10.3389/fnins.2022.848215
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- Article
Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 19, doi. 10.1186/1750-1326-7-19
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- Article
γ-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell Differentiation.
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- Mediators of Inflammation, 2015, v. 2015, p. 1, doi. 10.1155/2015/258168
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- Article
Gamma-secretase inhibitor DAPT suppresses glioblastoma growth via uncoupling of tumor vessel density from vessel function.
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- Clinical & Experimental Medicine, 2013, v. 13, n. 4, p. 271, doi. 10.1007/s10238-012-0203-8
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- Article
Influence of γ-Secretase Inhibitor 24-Diamino-5-Phenylthiazole DAPT on Platelet Activation.
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- Cellular Physiology & Biochemistry (Karger AG), 2016, v. 38, n. 2, p. 726, doi. 10.1159/000443029
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- Article
γ-Secretase inhibitor reverts the Notch signaling attenuation of osteogenic differentiation in aged bone marrow mesenchymal stem cells.
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- Cell Biology International, 2016, v. 40, n. 4, p. 439, doi. 10.1002/cbin.10583
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- Article
NICD/Hes1 影响心肌梗死后小鼠缺血心肌的血管新生.
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- Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu, 2023, v. 27, n. 23, p. 3635, doi. 10.12307/2023.588
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- Article
PRECISE RADIONUCLIDE LOCALIZATION USING UAV-BASED LIDAR AND GAMMA PROBE WITH REAL-TIME PROCESSING.
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- International Archives of the Photogrammetry, Remote Sensing & Spatial Information Sciences, 2019, v. XLII-3/W8, p. 503, doi. 10.5194/isprs-archives-XLII-3-W8-503-2019
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- Article
Inhibition of ཫ-secretase activity synergistically enhances tumour necrosis factor-related apoptosis-inducing ligand induced apoptosis in T-cell acute lymphoblastic leukemia cells via upregulation of death receptor 5.
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- Oncology Letters, 2016, v. 12, n. 4, p. 2900, doi. 10.3892/ol.2016.5011
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- Article
Gastric tumor-initiating CD44<sup>+</sup> cells and epithelial-mesenchymal transition are inhibited by γ-secretase inhibitor DAPT.
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- Oncology Letters, 2015, v. 10, n. 5, p. 3293, doi. 10.3892/ol.2015.3727
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- Article
Gastric cancer cell growth and epithelial-mesenchymal transition are inhibited by γ-secretase inhibitor DAPT.
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- Oncology Letters, 2014, v. 7, n. 6, p. 2160, doi. 10.3892/ol.2014.1980
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- Article
Tongluo Xingnao effervescent tablet reverses memory deficit and reduces plaque load in APPswe/PS1dE9 mice.
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- Experimental & Therapeutic Medicine, 2018, v. 15, n. 4, p. 4005, doi. 10.3892/etm.2018.5897
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- Article
The metabolism of human soluble amyloid precursor protein isoforms is quantifiable by a stable isotope labeling-tandem mass spectrometry method.
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- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-18869-3
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- Article
Acetylcholinesterase Inhibition Activity of Hippeastrum papilio (Ravenna) Van Scheepen (Amaryllidaceae) Using Zebrafish Brain Homogenates.
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- Life (2075-1729), 2023, v. 13, n. 8, p. 1721, doi. 10.3390/life13081721
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- Article
Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling.
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- Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00767-2
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- Article