We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Altered Protein Palmitoylation as Disease Mechanism in Neurodegenerative Disorders.
- Authors
Wlodarczyk, Jakub; Bhattacharyya, Raja; Dore, Kim; Ho, Gary P H; Martin, Dale D O; Mejias, Rebeca; Hochrainer, Karin
- Abstract
Palmitoylation, a lipid-based posttranslational protein modification, plays a crucial role in regulating various aspects of neuronal function through altering protein membrane-targeting, stabilities, and protein-protein interaction profiles. Disruption of palmitoylation has recently garnered attention as disease mechanism in neurodegeneration. Many proteins implicated in neurodegenerative diseases and associated neuronal dysfunction, including but not limited to amyloid precursor protein, β-secretase (BACE1), postsynaptic density protein 95, Fyn, synaptotagmin-11, mutant huntingtin, and mutant superoxide dismutase 1, undergo palmitoylation, and recent evidence suggests that altered palmitoylation contributes to the pathological characteristics of these proteins and associated disruption of cellular processes. In addition, dysfunction of enzymes that catalyze palmitoylation and depalmitoylation has been connected to the development of neurological disorders. This review highlights some of the latest advances in our understanding of palmitoylation regulation in neurodegenerative diseases and explores potential therapeutic implications.
- Publication
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024, Vol 44, Issue 40
- ISSN
1529-2401
- Publication type
Journal Article
- DOI
10.1523/JNEUROSCI.1225-24.2024