Evaluation of ethanol extracts from three species of Artocarpus as natural gastroprotective agents: in vivo and histopathological studies.

Fitrya, Fitrya; Amriani, Annisa; Novita, Rennie Puspa; Salsabila, Aufa; Siregar, Silvy Marina; Anafisya, Yunike

Artocarpus is a tropical plant known for its high concentration of secondary metabolites, especially flavonoids and phenolics. This study aims to evaluate the potential use of ethanol extracts obtained from three species of Artocarpus (Artocarpus altilis, Artocarpus champeden, and Artocarpus heterophyllus) as gastroprotective agents. The gastroprotective potential of the extracts at concentrations of 100, 200, and 400 mg/kg BW was studied in an animal model induced by absolute ethanol. The animals were subjected to extract pre-treatment for 14 days. Subsequently, the gastroprotective potential was evaluated based on the area of the lesion, the volume of gastric fluid, gastric pH, total acidity, gastric wall mucus content, and microscopic lesions. There was a significant decrease in the lesion area and gastric fluid volume in the animals that received pre-treated extracts of A. altilis, A. Champeden, and A. heterophyllus, as well as a significant increase in the pH and gastric wall mucus secretion when compared to the ethanol group (p0.05). Both macroscopic and microscopic examinations revealed a significant decrease in necrotic lesions. Extracts of A. altilis, A. Champeden, and A. heterophyllus are effective in lowering the risk of peptic ulcers since they have the potential to be used as natural gastroprotective agents.

THERAPEUTIC use of plant extracts; STATISTICS; MEDICINAL plants; IN vivo studies; ANIMAL experimentation; MICROSCOPY; GASTRIC juice; ONE-way analysis of variance; HEALTH outcome assessment; RATS; PLANT extracts; ETHANOL; GASTROINTESTINAL agents; HISTOLOGY; GASTRIC acidity determination; DATA analysis; PHARMACODYNAMICS

Journal of Complementary & Integrative Medicine, 2022, Vol 19, Issue 4, p967

1553-3840

Academic Journal

10.1515/jcim-2022-0105