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- Title
New roles for GAPDH, Hsp90, and NO in regulating heme allocation and hemeprotein function in mammals.
- Authors
Stuehr, Dennis J.; Dai, Yue; Biswas, Pranjal; Sweeny, Elizabeth A.; Ghosh, Arnab
- Abstract
The intracellular trafficking of mitochondrial heme presents a fundamental challenge to animal cells. This article provides some background on heme allocation, discusses some of the concepts, and then reviews research done over the last decade, much in the author's laboratory, that is uncovering unexpected and important roles for glyceraldehyde 3-phosphate dehydrogenase (GAPDH), heat shock protein 90 (hsp90), and nitric oxide (NO) in enabling and regulating the allocation of mitochondrial heme to hemeproteins that mature and function outside of the mitochondria. A model for how hemeprotein functions can be regulated in cells through the coordinate participation of GAPDH, hsp90, and NO in allocating cellular heme is presented.
- Subjects
HEAT shock proteins; HEME; GLYCERALDEHYDEPHOSPHATE dehydrogenase; HEMOPROTEINS; MYOGLOBIN
- Publication
Biological Chemistry, 2022, Vol 403, Issue 11/12, p1005
- ISSN
1431-6730
- Publication type
Academic Journal
- DOI
10.1515/hsz-2022-0197