Works matching AU Dinh, Thanh Thi

Results: 52
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    It has been reported that lactoferrin (LF) participates in the host immune response against Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) invasion by enhancing NK cell activity and stimulating neutrophil aggregation and adhesion. We further investigated the role of LF in the entry of SARS pseudovirus into HEK293E/ACE2-Myc cells. Our results reveal that LF inhibits SARS pseudovirus infection in a dose-dependent manner. Further analysis suggested that LF was able to block the binding of spike protein to host cells at 4°C, indicating that LF exerted its inhibitory function at the viral attachment stage. However, LF did not disrupt the interaction of spike protein with angiotensin-converting enzyme 2 (ACE2), the functional receptor of SARS-CoV. Previous studies have shown that LF colocalizes with the widely distributed cell-surface heparan sulfate proteoglycans (HSPGs). Our experiments have also confirmed this conclusion. Treatment of the cells with heparinase or exogenous heparin prevented binding of spike protein to host cells and inhibited SARS pseudovirus infection, demonstrating that HSPGs provide the binding sites for SARS-CoV invasion at the early attachment phase. Taken together, our results suggest that, in addition to ACE2, HSPGs are essential cell-surface molecules involved in SARS-CoV cell entry. LF may play a protective role in host defense against SARS-CoV infection through binding to HSPGs and blocking the preliminary interaction between SARS-CoV and host cells. Our findings may provide further understanding of SARS-CoV pathogenesis and aid in treatment of this deadly disease.

    Published in:
    PLoS ONE, 2011, v. 6, n. 8, p. 1, doi. 10.1371/journal.pone.0023711
    By:
    • Manabe, Toshie;
    • Thuy, Pham Thi Phuong;
    • Can, Vu Van;
    • Takasaki, Jin;
    • Huyen, Dinh Thi Thanh;
    • Chau, Nguyen Thi My;
    • Shimbo, Takuro;
    • Ha, Bui Thi Thu;
    • Izumi, Shinyu;
    • Hanh, Tran Thuy;
    • Chau, Ngo Quy;
    • Kudo, Koichiro
    Publication type:
    Article
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    Occurrence and ecological risks of antibiotics and antiparasitics in surface water in urban lakes in Hanoi city, Vietnam.

    Published in:
    Environmental Science & Pollution Research, 2025, v. 32, n. 3, p. 1447, doi. 10.1007/s11356-024-35726-0
    By:
    • Le, Nhu Da;
    • Dinh, Thi Thanh Huyen;
    • Vu, Thi Huong;
    • Le, Phuong Thu;
    • Nguyen, Thi Mai Huong;
    • Hoang, Thi Thu Ha;
    • Rochelle-Newall, Emma;
    • Phung, Thi Xuan Binh;
    • Duong, Thi Thuy;
    • Luu, Thi Huyen Trang;
    • Kieu, Thi Lan Phuong;
    • Nguyen, Thi Anh Huong;
    • Nguyen, Tien Dat;
    • Le, Thi Phuong Quynh
    Publication type:
    Article
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    Nurse–patient communication: A quality assessment in public hospital.

    Published in:
    International Journal of Healthcare Management, 2021, v. 14, n. 4, p. 1127, doi. 10.1080/20479700.2020.1752987
    By:
    • Tran, Tiep Viet;
    • Tran, Tinh Dang;
    • Nguyen, Anh Quoc;
    • Dinh, Thanh Thi;
    • Le, Anh Thi Kim;
    • Tran, Hieu Ba;
    • Vu, Phuong Thi;
    • Nguyen, Hoai Thu;
    • Dang, Linh Vu Phuong
    Publication type:
    Article
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    The Relationship Between Low-Grade Inflammation and Common Femoral Artery Intima-Media Thickness in Newly Diagnosed Type 2 Diabetes Mellitus.

    Published in:
    Clinical Medicine Insights: Endocrinology & Diabetes, 2025, p. 1, doi. 10.1177/11795514251323837
    By:
    • Tien Nguyen, Son;
    • Dinh Le, Tuan;
    • Dinh, Hoa Trung;
    • Ho Thi Nguyen, Lan;
    • Thi Nguyen, Giang;
    • Hien Vu, Trinh;
    • Huy Nguyen, Thong;
    • Luong Cong, Thuc;
    • Van Nguyen, Binh;
    • Duy Nguyen, Toan;
    • Quang Nguyen, Huy;
    • Van Nguyen, Ba;
    • Dinh Thi Thanh, Thuy;
    • Duong Huy, Hoang
    Publication type:
    Article
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    Novel (E)-3-(3-Oxo-4-substituted-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-N-hydroxypropenamides as Histone Deacetylase Inhibitors: Design, Synthesis and Bioevaluation.

    Published in:
    Chemistry & Biodiversity, 2023, v. 20, n. 5, p. 1, doi. 10.1002/cbdv.202201030
    By:
    • Doan Minh Sang;
    • Ik Ho Na;
    • Duong Tien Anh;
    • Do Thi Mai Dung;
    • Nguyen Thi Thu Hang;
    • Phuong-Anh, Nguyen T.;
    • Pham-The Hai;
    • Dao Thi Kim Oanh;
    • Truong Thanh Tung;
    • Soo Jung Lee;
    • Joo Hee Kwon;
    • Jong Soon Kang;
    • Sang-Bae Han;
    • Dinh Thi Thanh Hai;
    • Nguyen-Hai Nam
    Publication type:
    Article