TSH-receptor autoantibodies in patients with chronic thyroiditis and hypothyroidism.

Giannone, Mariella; Dalla Costa, Miriam; Sabbadin, Chiara; Garelli, Silvia; Salvà, Monica; Masiero, Stefano; Plebani, Mario; Faggian, Diego; Gallo, Nicoletta; Presotto, Fabio; Bertazza, Loris; Nacamulli, Davide; Censi, Simona; Mian, Caterina; Betterle, Corrado

Keywords: autoimmune thyroid diseases; chronic thyroiditis; hypothyroidism; TSH-receptor autoantibodies; TSH-receptor blocking antibodies; TSH-receptor stimulating antibodies EN autoimmune thyroid diseases chronic thyroiditis hypothyroidism TSH-receptor autoantibodies TSH-receptor blocking antibodies TSH-receptor stimulating antibodies 1020 1030 11 05/26/22 20220601 NES 220601 Introduction Chronic thyroiditis (CT) is one of the most prevalent autoimmune diseases [[1]], [[2]], [[3]] and is associated with autoantibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) [[4]], [[5]], [[6]]. TSH levels were significantly higher in TRAb-positive than in TRAb-negative patients and TSH levels were significantly higher in the patients with high levels of TRAb (>7.5 IU/L) compared to patients with lower levels of TRAb (<7.5 IU/L). After excluding the patients with ophthalmopathy 31/240 (12.9%) of CT patients had TRAb >2.5 IU/L. The prevalence and concentrations of TRAb in CT patients was further analysed in females and in males aged 16-45 years and >45 years. Results TRAb were detected in 32/245 (13.1%) patients with CT and hypothyroidism and ranged from 2.5 IU/L to 231 IU/L; 14/245 (5.7%) had TRAb between >2.5 and 7.5 IU/L, 18/245 (7.3%) had TRAb >7.5 IU/L while 213/245 (86.9%) had TRAb levels <2.5 IU/L. The median levels of TSH in TRAb-positive and negative patients are summarized in Table 1.

AUTOANTIBODIES; THYROTROPIN receptors; HYPOTHYROIDISM; THYROIDITIS

Clinical Chemistry & Laboratory Medicine, 2022, Vol 60, Issue 7, p1020

1434-6621

Academic Journal

10.1515/cclm-2022-0162