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- Title
ABO blood group and von Willebrand factor: biological implications.
- Authors
Franchini, Massimo; Crestani, Silvia; Frattini, Francesco; Sissa, Cinzia; Bonfanti, Carlo
- Abstract
ABO blood group antigens are complex carbohydrate molecules expressed on the surface of red blood cells and a variety of human cells and tissues. It is well known that ABO blood type exerts a profound influence on hemostasis, being a major determinant of von Willebrand factor (VWF), and consequently factor VIII, plasma levels. In this review, we will focus on the molecular mechanisms underlying the interaction between ABO blood group and VWF in normal and pathological conditions.
- Subjects
ABO blood group system; BLOOD groups; ERYTHROCYTES; HEMOSTASIS; DESMOPRESSIN; VON Willebrand disease
- Publication
Clinical Chemistry & Laboratory Medicine, 2014, Vol 52, Issue 9, p1273
- ISSN
1434-6621
- Publication type
Academic Journal
- DOI
10.1515/cclm-2014-0564