Title: Time to step into better heart failure therapy.
Authors: Howlett, Jonathan
Abstract: The article discusses the increasing prevalence and burden of heart failure, particularly heart failure with reduced ejection fraction (HFrEF), and the importance of optimal treatment with four classes of disease-modifying drugs. A cost-effectiveness study highlighted the benefits of more aggressive drug-titration strategies in improving quality-adjusted life years for patients with heart failure. The study emphasized the need for tailored approaches to titration and the implementation of simultaneous initiation of heart failure therapy to focus on safety, tolerability, and efficiency. The findings suggest that simultaneous or near-simultaneous administration of guideline-directed medical therapy (GDMT) to patients with HFrEF is highly cost-effective, but real-world outcomes may vary due to patient factors and tolerability issues.
Subjects: MEDICAL care; HEART failure patients; HEART failure; MINERALOCORTICOID receptors; QUALITY-adjusted life years; ADRENERGIC receptors
Publication: Canadian Medical Association Journal (CMAJ), 2024, Vol 196, Issue 36, pE1239
ISSN: 0820-3946
Publication type: Academic Journal
DOI: 10.1503/cmaj.241426

Time to step into better heart failure therapy.

Howlett, Jonathan