用于肿瘤诊疗的金属-多酚网络多功能材料.

刘 涛; 冯 俊; 张先正

Polyphenols are widely spread in nature especially in plants. Many polyphenols have been approved by the FDA with the widespread utilization in food and medicine. Metal ions have found important applications in the fields of biocatalysis and chemical catalysis, bioimaging, diagnosis and disease treatment, etc. The digalloyl groups rich in polyphenols can serve as chelating sites for multivalent metal ions to induce rapid self-crosslinking of polyphenols, giving rise to stable metal-polyphenol networks (MPN) without heat treatment, use of organic solvents and special instruments or additive chemicals. Metal-polyphenol networks share the excellent adhesion capability with parent polyphenols, thus readily adhere to various interfaces of different substrates (e.g., polymeric and inorganic materials, cells, proteins, virus, bacteria, yeast), regardless of the origins, shapes and structures. By taking advantage of the selected templates (e.g., 2D materials, solid sphere/rod, hollow vesicle, nanowires, nanosheets, nanocubes), various nanostructures coated with metal-polyphenol networks are easily accessible as desired. This unique characteristic can function as an intermediate to bridge the intrinsic properties of metal-polyphenol networks to the versatile functions of nanotemplates, such as the loading capacity of various cargoes (e.g. hydrophobic/hydrophilic, low molecular weight/macromolecular, and artificial/natural substances). The abundant phenol groups in polyphenols also allow for surface modification through chemical conjugation, π-π stacking and so on. In addition, the environment-responsive conversion between the self-assembled and the disassociated metal-polyphenol networks endows these materials with great potential for drug delivery. This supramolecular self-assembly network with facile and green preparation process can be developed as a kind of multifunctional nanoplatforms for advanced applications in the fields of bionics, materials science, and biomedicine, particularly for diagnosis and treatment of tumor. In this review, we have summarized the recent development of metal-polyphenol nanomaterials for biomedical applications, including a brief introduction of the related work that has been performed by our research group.

UNITED States. Food & Drug Administration; MATERIALS science; ORGANIC solvents; MOLECULAR weights; CHARACTERISTIC functions; METAL ions; POLYPHENOLS; POLYMERIC nanocomposites

Journal of Functional Polymers, 2019, Vol 32, Issue 4, p421

1008-9357

Academic Journal

10.14133/j.cnki.1008-9357.20181114001