Results
Title

β-多肽聚合物的优化合成及其抗菌活性.

Authors

杨宁宁; 张丹丰; 张强; 马鹏程; 张思; 齐凡; 刘润辉

Abstract

In order to address the incomplete polymerization of different monomers resulted by their different reactivities,we perform a polymerization ofβ-lactam monomer bearing hydrophobic sidechains,3,3,4,4-tetramethylazetidine-2-one(TM)and another monomer having positively charged groups in the sidechain,3-(tert-butyloxycarbonyl aminomethyl)-4,4-dimethylazetidin-2-one(MM),which show slow reactivity during polymerization.The polymerization condition of these monomers was optimized by exploring different monomer concentrations,reaction solvents and initiators.The results indicated that initiators with potassium counter ion can initiate a faster polymerization ofβ-lactam monomers and result in a higher conversion of monomers compared with that with lithium counter ion.In addition,increasing the reactant concentration and optimizing the reaction solvent could also increase the reaction rate.The investigations on the minimum inhibitory concentration(ρMIC)of synthesized polymers revealed that the polymers obtained at the optimized reaction conditions presented slightly increased antimicrobial activities against some types of microbes

Subjects

COUNTER-ions; POTASSIUM ions; MONOMERS; LACTAMS; POLYMERIZATION; POLYMERS

Publication

Journal of Functional Polymers, 2019, Vol 32, Issue 2, p233

ISSN

1008-9357

Publication type

Academic Journal

DOI

10.14133/j.cnki.1008-9357.20180501001