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- Title
胞磷胆碱钠口服剂型改善血管性认知障碍的药品临床综合评价.
- Authors
李晓曦; 邢晓璇; 冯英楠; 王之舟; 王 可; 庄 伟; 张 蔷; 张 兰; 董宪喆
- Abstract
OBJECTIVE: To perform a clinical comprehensive evaluation on oral dosage of citicoline sodium in the treatment of vascular cognitive impairment based on evidence-based evidence, so as to provide reference for clinical rational application of citicoline sodium. METHODS: PubMed, the Cochrane Library, CNKI, Wanfang Data and other Chinese and English database were systematically retrieved ( the retrieval time was from the establishment of the database to May 11th, 2024) to analyze the effectiveness and and safety of Citicoline sodium tablets/ capsules in the treatment of vascular cognitive impairment, and quality evaluation on related literature was conducted. The National Medical Products Administration and other professional websites as well as the Sunshine Procurement Service Platform, dispensatory were searched to analyze the economical efficiency, innovation, appropriateness and accessibility of Citicoline sodium tablets/ capsules. RESULTS: Meta-analysis on effectiveness indicated that the oral dosage of citicoline sodium was better than the placebo in terms of improving the cognitive level (MD = 3. 64,95% CI = 2. 81- 4. 46), self-care ability (MD= 11. 31,95%CI = 9. 00-13. 62), cognitive function (MD= 3. 55,95%CI = 2. 09-5. 02), neurologic impairment (MD= - 6. 91,95% CI = - 8. 10-- 5. 72) and total effective rate (OR = 2. 61,95% CI = 1. 85- 3. 67), with statistically significant differences (P<0. 05). The efficacy of oral dosage of citicoline sodium was similar to that of the placebo, the difference was not statistically significant (OR = 0. 80,95%CI = 0. 47-1. 38,P = 0. 42). In terms of economical efficiency, the oral dosage of cytarabine sodium was the class B medicine in National Drug Reimbursement List. In terms of innovation, cytarabine sodium was the only drug that had neuroprotective and neurorestorative effects in phase Ⅲ clinical trials. In terms of appropriateness, oral dosage of cytarabine sodium was easy to use. In terms of accessibility, oral dosage of cytarabine sodium had wide coverage and better affordability. CONCLUSIONS: The clinical efficacy of Cytarabine sodium tablets/ capsules in improving vascular cognitive impairment is significant, which has high safety and moderately economical efficiency, with good innovation, appropriateness, accessibility and affordability.
- Subjects
CYTIDINE diphosphate choline; MEDICAL supplies; COGNITION disorders; DATABASES; COGNITIVE ability
- Publication
Evaluation & Analysis of Drug-Use in Hospitals of China / Zhongguo Yiyuan Yongyao Pingjia yu Fenxi, 2024, Vol 24, Issue 12, p1508
- ISSN
1672-2124
- Publication type
Academic Journal
- DOI
10.14009/j.issn.1672-2124.2024.12.021