Works matching DE "SPHINGOSINE kinase"

Results: 383

Sphingosine kinase 1 inhibition aggravates vascular smooth muscle cell calcification.

Published in:

Pflügers Archiv: European Journal of Physiology, 2025, v. 477, n. 6, p. 815, doi. 10.1007/s00424-025-03068-6

By:

Razazian, Mehdi;
Bahiraii, Sheyda;
Jannat, Isratul;
Tiffner, Adéla;
Beilhack, Georg;
Levkau, Bodo;
Voelkl, Jakob;
Alesutan, Ioana

Publication type:

Article

Six pairs of enantiomeric prenylated flavonoids with cytotoxic activities from Epimedium sagittatum Maxim.

Published in:

Natural Products & Bioprospecting, 2025, v. 15, n. 1, p. 1, doi. 10.1007/s13659-025-00510-1

By:

Xie, Shuang-Shuang;
Yu, Xiang;
Tie, Qi-Mei;
Zhang, Jing-Ke;
Zhang, Bei-Bei;
Zeng, Meng-Nan;
Zheng, Xiao-Ke;
Feng, Wei-Sheng

Publication type:

Article

Generation of mice with hepatocyte-specific conditional deletion of sphingosine kinase 1.

Published in:

Transgenic Research, 2020, v. 29, n. 4, p. 419, doi. 10.1007/s11248-020-00211-0

By:

Yu, Jinfeng;
Dong, Jiale;
Chen, Kangdi;
Ding, Yaping;
Yang, Zhicheng;
Lan, Tian

Publication type:

Article

Metformin alleviates inflammation in oxazolone induced ulcerative colitis in rats: plausible role of sphingosine kinase 1/sphingosine 1 phosphate signaling pathway.

Published in:

Immunopharmacology & Immunotoxicology, 2021, v. 43, n. 2, p. 192, doi. 10.1080/08923973.2021.1878214

By:

El-Mahdy, Nageh Ahmed;
El-Sayad, Magda El-Sayed;
El-Kadem, Aya Hassan;
Abu-Risha, Sally EL-Sayed

Publication type:

Article

Sphingosine kinase 1, a potential drug target for breast cancer therapy in in silico models: A molecular docking verification.

Published in:

South Asian Journal of Experimental Biology, 2023, v. 13, n. 6, p. 416, doi. 10.38150/sajeb.13(6).p416-422

By:

Prabhavathy, G.;
Sabarimanikandan, M.;
Aruldoss, G.;
Sundaramoorthy, M.

Publication type:

Article

ATP release from erythrocytes: A role of adenosine1.

Published in:

Clinical Hemorheology & Microcirculation, 2022, v. 80, n. 2, p. 61, doi. 10.3233/CH-221379

By:

Misiti, Francesco;
Carelli-Alinovi, Cristiana;
Rodio, Angelo

Publication type:

Article

Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00556

By:

Cannavo, Alessandro;
Liccardo, Daniela;
Komici, Klara;
Corbi, Graziamaria;
de Lucia, Claudio;
Femminella, Grazia D.;
Elia, Andrea;
Bencivenga, Leonardo;
Ferrara, Nicola;
Koch, Walter J.;
Paolocci, Nazareno;
Rengo, Giuseppe

Publication type:

Article

Measles Virus Infection Fosters Dendritic Cell Motility in a 3D Environment to Enhance Transmission to Target Cells in the Respiratory Epithelium.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.01294

By:

Derakhshani, Shaghayegh;
Kurz, Andreas;
Japtok, Lukasz;
Schumacher, Fabian;
Pilgram, Lisa;
Steinke, Maria;
Kleuser, Burkhard;
Sauer, Markus;
Schneider-Schaulies, Sibylle;
Avota, Elita

Publication type:

Article

Corrigendum: Sphingosine 1-Phosphate: A Novel Target for Lung Disorders.

Published in:

2018

By:

Mohammed, Sabira;
Harikumar, K. B.

Publication type:

Correction Notice

Targeting Sphingosine Kinase Isoforms Effectively Reduces Growth and Survival of Neoplastic Mast Cells With D816V-KIT.

Published in:

Frontiers in Immunology, 2018, p. 1, doi. 10.3389/fimmu.2018.00631

By:

Bandara, Geethani;
Muñoz-Cano, Rosa;
Tobío, Araceli;
Yin, Yuzhi;
Komarow, Hirsh D.;
Desai, Avanti;
Metcalfe, Dean D.;
Olivera, Ana

Publication type:

Article

Modulation of sphingosine 1-phosphate (S1P) attenuates spatial learning and memory impairments in the valproic acid rat model of autism.

Published in:

Psychopharmacology, 2018, v. 235, n. 3, p. 873, doi. 10.1007/s00213-017-4805-4

By:

Hongmei Wu;
Quanzhi Zhang;
Jingquan Gao;
Caihong Sun;
Jia Wang;
Wei Xia;
Yonggang Cao;
Yanqiu Hao;
Lijie Wu

Publication type:

Article

Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1.

Published in:

Oncogene, 2014, v. 33, n. 48, p. 5559, doi. 10.1038/onc.2013.502

By:

Pham, D H;
Powell, J A;
Gliddon, B L;
Moretti, P A B;
Tsykin, A;
Van der Hoek, M;
Kenyon, R;
Goodall, G J;
Pitson, S M

Publication type:

Article

Sphk1/S1P/S1PR1 Signaling is Involved in the Development of Autoimmune Thyroiditis in Patients and NOD.H-2h4 Mice.

Published in:

Thyroid, 2019, v. 29, n. 5, p. 700, doi. 10.1089/thy.2018.0065

By:

Han, Cheng;
He, Xue;
Xia, Xinghai;
Guo, Jiahui;
Liu, Aihua;
Liu, Xin;
Wang, Xinyi;
Li, Chengyan;
Peng, Shiqiao;
Zhao, Wei;
Zhou, Mi;
Shi, Xiaoguang;
Li, Yushu;
Li, Yongze;
Shan, Zhongyan;
Teng, Weiping

Publication type:

Article

The Expression and Clinical Significance of Sphingosine Kinase 1 and Vascular Endothelial Growth Factor in Endometrial Carcinoma.

Published in:

Emergency Medicine International, 2022, p. 1, doi. 10.1155/2022/6716143

By:

Yu, Hong;
Dejizhuoga;
Huang, Wei;
Wang, Donglian;
Gamaquzhen;
Jia, Xiaomin;
Feng, Hao

Publication type:

Article

Assessment of the Effects of Sphingosine Kinase 1/Sphingosine-1-Phosphate on Microangiogenesis at Rat Myofascial Trigger Points Using Contrast-Enhanced Ultrasonography.

Published in:

Journal of Pain Research, 2024, v. 17, p. 609, doi. 10.2147/JPR.S437111

By:

Fang, Xin;
Yin, Yalong;
Lun, Haimei;
Liu, Yaoli;
Zhu, Shangyong

Publication type:

Article

S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2023, v. 42, n. 1, p. 1, doi. 10.1186/s13046-022-02589-7

By:

Wang, Xingtong;
Guo, Wei;
Shi, Xiaoju;
Chen, Yujia;
Yu, Youxi;
Du, Beibei;
Tan, Min;
Tong, Li;
Wang, Anna;
Yin, Xianying;
Guo, Jing;
Martin, Robert C.;
Bai, Ou;
Li, Yan

Publication type:

Article

Sphingosine-1-phosphate promotes liver fibrosis in metabolic dysfunction-associated steatohepatitis.

Published in:

PLoS ONE, 2024, v. 19, n. 5, p. 1, doi. 10.1371/journal.pone.0303296

By:

Osawa, Yosuke;
Kawai, Hironari;
Nakashima, Keigo;
Nakaseko, Yuichi;
Suto, Daisuke;
Yanagida, Keisuke;
Hashidate-Yoshida, Tomomi;
Mori, Taizo;
Yoshio, Sachiyo;
Ohtake, Takaaki;
Shindou, Hideo;
Kanto, Tatsuya

Publication type:

Article

Human Remyelination Promoting Antibody Stimulates Astrocytes Proliferation Through Modulation of the Sphingolipid Rheostat in Primary Rat Mixed Glial Cultures.

Published in:

Neurochemical Research, 2019, v. 44, n. 6, p. 1460, doi. 10.1007/s11064-018-2701-x

By:

Grassi, Sara;
Giussani, Paola;
Prioni, Simona;
Button, Donald;
Cao, Jing;
Hakimi, Irina;
Sarmiere, Patrick;
Srinivas, Maya;
Cabitta, Livia;
Sonnino, Sandro;
Prinetti, Alessandro

Publication type:

Article

Sphingosine Kinase-1 Protects Differentiated N2a Cells Against Beta-Amyloid25-35-Induced Neurotoxicity Via the Mitochondrial Pathway.

Published in:

Neurochemical Research, 2014, v. 39, n. 5, p. 932, doi. 10.1007/s11064-014-1290-6

By:

Yang, Yang;
Wang, Min;
Lv, Bingjie;
Ma, Rong;
Hu, Jing;
Dun, Yaoyan;
Sun, Shenggang;
Li, Gang

Publication type:

Article

Sphingosine Kinases/Sphingosine-1-Phosphate and Death Signalling in APP-Transfected Cells.

Published in:

Neurochemical Research, 2014, v. 39, n. 4, p. 645, doi. 10.1007/s11064-014-1240-3

By:

Gassowska, Magdalena;
Cieslik, Magdalena;
Wilkaniec, Anna;
Strosznajder, Joanna

Publication type:

Article

Co-administration phenoxodiol with doxorubicin synergistically inhibit the activity of sphingosine kinase-1 (SphK1), a potential oncogene of osteosarcoma, to suppress osteosarcoma cell growth both in vivo and in vitro

Published in:

Molecular Oncology, 2012, v. 6, n. 4, p. 392, doi. 10.1016/j.molonc.2012.04.002

By:

Yao, Chen;
Wu, Sujia;
Li, Dong;
Ding, Huimin;
Wang, Zuyu;
Yang, Yongjiang;
Yan, Shichang;
Gu, Zhangping

Publication type:

Article

Discovery and design of dual inhibitors targeting Sphk1 and Sirt1.

Published in:

Journal of Molecular Modeling, 2023, v. 29, n. 5, p. 1, doi. 10.1007/s00894-023-05551-2

By:

Liu, Jin;
Zhao, Hui-lin;
He, Lei;
Yu, Ri-lei;
Kang, Cong-min

Publication type:

Article

Cytokine‐Induced and Stretch‐Induced Sphingosine 1‐Phosphate Production by Enthesis Cells Could Favor Abnormal Ossification in Spondyloarthritis.

Published in:

Journal of Bone & Mineral Research, 2019, v. 34, n. 12, p. 2264, doi. 10.1002/jbmr.3844

By:

El Jamal, Alaeddine;
Briolay, Anne;
Mebarek, Saida;
Le Goff, Benoit;
Blanchard, Frédéric;
Magne, David;
Brizuela, Leyre;
Bougault, Carole

Publication type:

Article

Enhanced inflammasome activation and reduced sphingosine-1 phosphate S1P signalling in a respiratory mucoobstructive disease model.

Published in:

Journal of Inflammation, 2020, v. 17, n. 1, p. 1, doi. 10.1186/s12950-020-00248-2

By:

Tran, Hai B.;
Macowan, Matthew G.;
Abdo, Adrian;
Donnelley, Martin;
Parsons, David;
Hodge, Sandra

Publication type:

Article

MicroRNA-338-3p suppresses cell proliferation and induces apoptosis of non-small-cell lung cancer by targeting sphingosine kinase 2.

Published in:

Cancer Cell International, 2017, v. 17, p. 1, doi. 10.1186/s12935-017-0415-9

By:

Guowei Zhang;
Hao Zheng;
Guojun Zhang;
Ruirui Cheng;
Chunya Lu;
Yijie Guo;
Guoqiang Zhao

Publication type:

Article

Sphingosine kinase 1 mediates head & neck squamous cell carcinoma invasion through sphingosine 1-phosphate receptor 1.

Published in:

Cancer Cell International, 2014, v. 14, n. 1, p. 1, doi. 10.1186/s12935-014-0076-x

By:

Tamashiro, Paulette M.;
Furuya, Hideki;
Shimizu, Yoshiko;
Toshihiko Kawamori

Publication type:

Article

Enzymatic independent role of sphingosine kinase 2 in regulating the expression of type I interferon during influenza A virus infection.

Published in:

PLoS Pathogens, 2022, v. 18, n. 9, p. 1, doi. 10.1371/journal.ppat.1010794

By:

Xu, Mengqiong;
Xia, Sisi;
Wang, Mei;
Liu, Xiaolian;
Li, Xin;
Chen, Weijie;
Wang, Yaohao;
Li, Hongjian;
Xia, Chuan;
Chen, Jun;
Wu, Jianguo

Publication type:

Article

Sphingolipids in early viral replication and innate immune activation.

Published in:

Biological Chemistry, 2018, v. 399, n. 10, p. 1115, doi. 10.1515/hsz-2018-0181

By:

Bezgovsek, Judith;
Gulbins, Erich;
Friedrich, Sarah-Kim;
Lang, Karl S.;
Duhan, Vikas

Publication type:

Article

Sphingosine kinase 2 deficiency increases proliferation and migration of renal mouse mesangial cells and fibroblasts.

Published in:

Biological Chemistry, 2015, v. 396, n. 6/7, p. 813, doi. 10.1515/hsz-2014-0289

By:

Schwalm, Stephanie;
Timcheva, Tankica Maneva;
Filipenko, Iuliia;
Ebadi, Mahsa;
Hofmann, Lotte P.;
Zangemeister-Wittke, Uwe;
Pfeilschifter, Josef;
Huwiler, Andrea

Publication type:

Article

Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors.

Published in:

Biological Chemistry, 2015, v. 396, n. 6/7, p. 783, doi. 10.1515/hsz-2014-0276

By:

Dong Dong Zhang;
Linke, Bona;
Jing Suo;
Zivkovic, Aleksandra;
Schreiber, Yannick;
Ferreirós, Nerea;
Henke, Marina;
Geisslinger, Gerd;
Stark, Holger;
Scholich, Klaus

Publication type:

Article

Highlight: Molecular Medicine of Sphingolipids.

Published in:

Biological Chemistry, 2015, v. 396, n. 6/7, p. 569, doi. 10.1515/hsz-2015-0163

By:

Gulbins, Erich

Publication type:

Article

Influence of SphK1 on Inflammatory Responses in Lipopolysaccharide-Challenged RAW 264.7 Cells.

Published in:

Cell Biochemistry & Biophysics, 2024, v. 82, n. 3, p. 2511, doi. 10.1007/s12013-024-01364-z

By:

Wei, Chao-shun;
Song, Lin-li;
Peng, Zi-xi;
Wang, Xiao-Li

Publication type:

Article

Hyperoxia-induced S1P1 signaling reduced angiogenesis by suppression of TIE-2 leading to experimental bronchopulmonary dysplasia.

Published in:

Cell Biochemistry & Biophysics, 2021, v. 79, n. 3, p. 561, doi. 10.1007/s12013-021-01014-8

By:

Sudhadevi, Tara;
Jafri, Anjum;
Ha, Alison W.;
Basa, Prathima;
Thomas, Jaya M.;
Fu, Panfeng;
Wary, Kishore;
Mehta, Dolly;
Natarajan, Viswanathan;
Harijith, Anantha

Publication type:

Article

Sphingosine Kinase 1 Regulates the Pulmonary Vascular Immune Response.

Published in:

Cell Biochemistry & Biophysics, 2021, v. 79, n. 3, p. 517, doi. 10.1007/s12013-021-01006-8

By:

Bai, Yang;
Lockett, Angelia D.;
Gomes, Marta T.;
Stearman, Robert S.;
Machado, Roberto F.

Publication type:

Article

Sphingosine Kinase-1 Activation Causes Acquired Resistance Against Sunitinib in Renal Cell Carcinoma Cells.

Published in:

Cell Biochemistry & Biophysics, 2014, v. 68, n. 2, p. 419, doi. 10.1007/s12013-013-9723-4

By:

Gao, Hui;
Deng, Lichun

Publication type:

Article

A chemical screen for modulators of mRNA translation identifies a distinct mechanism of toxicity for sphingosine kinase inhibitors.

Published in:

PLoS Biology, 2021, v. 19, n. 5, p. 1, doi. 10.1371/journal.pbio.3001263

By:

Corman, Alba;
Kanellis, Dimitris C.;
Michalska, Patrycja;
Häggblad, Maria;
Lafarga, Vanesa;
Bartek, Jiri;
Carreras-Puigvert, Jordi;
Fernandez-Capetillo, Oscar

Publication type:

Article

Beneficial Effects of Hordenine on a Model of Ulcerative Colitis.

Published in:

Molecules, 2023, v. 28, n. 6, p. 2834, doi. 10.3390/molecules28062834

By:

Xu, Zhengguang;
Zhang, Qilian;
Ding, Ce;
Wen, Feifei;
Sun, Fang;
Liu, Yanzhan;
Tao, Chunxue;
Yao, Jing

Publication type:

Article

Mebendazole Impedes the Proliferation and Migration of Pancreatic Cancer Cells through SK1 Inhibition Dependent Pathway.

Published in:

Molecules, 2022, v. 27, n. 23, p. 8127, doi. 10.3390/molecules27238127

By:

Limbu, Khem Raj;
Chhetri, Rashmi Bhandari;
Oh, Yoon Sin;
Baek, Dong Jae;
Park, Eun-Young

Publication type:

Article

Synthesis of PP2A-Activating PF-543 Derivatives and Investigation of Their Inhibitory Effects on Pancreatic Cancer Cells.

Published in:

Molecules, 2022, v. 27, n. 10, p. 3346, doi. 10.3390/molecules27103346

By:

Kim, Su Bin;
Oh, Yoon Sin;
Kim, Kwang Joon;
Cho, Sung Woo;
Park, Seung Ki;
Baek, Dong Jae;
Park, Eun-Young

Publication type:

Article

Approaches to the Potential Therapy of COVID-19: A General Overview from the Medicinal Chemistry Perspective.

Published in:

Molecules, 2022, v. 27, n. 3, p. 658, doi. 10.3390/molecules27030658

By:

Menéndez, J. Carlos

Publication type:

Article

ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P 1 Agonist and Functional Antagonist Potency In Vitro and In Vivo.

Published in:

Molecules, 2021, v. 26, n. 17, p. 5134, doi. 10.3390/molecules26175134

By:

Stepanovska Tanturovska, Bisera;
Zivkovic, Aleksandra;
Imeri, Faik;
Homann, Thomas;
Kleuser, Burkhard;
Stark, Holger;
Huwiler, Andrea

Publication type:

Article

Verification of the Necessity of the Tolyl Group of PF-543 for Sphingosine Kinase 1 Inhibitory Activity.

Published in:

Molecules, 2020, v. 25, n. 11, p. 2484, doi. 10.3390/molecules25112484

By:

Kim, Su Bin;
Lee, Taeho;
Moon, Hong Seop;
Ki, Sung Hwan;
Oh, Yoon Sin;
Lee, Joo-Youn;
Kim, Sang-Bum;
Park, Jeong-Eun;
Kwon, Yongseok;
Kim, Sanghee;
Baek, Dong Jae;
Park, Eun-Young;
Muñoz-Torrero, Diego;
De Pascual-Teresa, Beatriz

Publication type:

Article

Synthesis and Biological Evaluation of BODIPY-PF-543.

Published in:

Molecules, 2019, v. 24, n. 23, p. 4408, doi. 10.3390/molecules24234408

By:

Shrestha, Jitendra;
Hwang, Gil Tae;
Lee, Taeho;
Kim, Seon Woong;
Oh, Yoon Sin;
Kwon, Yongseok;
Hong, Seung Woo;
Kim, Sanghee;
Seop Moon, Hong;
Baek, Dong Jae;
Park, Eun-Young

Publication type:

Article

Synthesis of Novel FTY720 Analogs with Anticancer Activity through PP2A Activation.

Published in:

Molecules, 2018, v. 23, n. 11, p. 2750, doi. 10.3390/molecules23112750

By:

Shrestha, Jitendra;
Ki, Sung Hwan;
Shin, Sang Mi;
Kim, Seon Woong;
Lee, Joo-Youn;
Jun, Hee-Sook;
Lee, Taeho;
Kim, Sanghee;
Baek, Dong Jae;
Park, Eun-Young

Publication type:

Article

Sphingosine kinase 1/sphingosine-1-phosphate regulates the expression of interleukin-17A in activated microglia in cerebral ischemia/reperfusion.

Published in:

Inflammation Research, 2016, v. 65, n. 7, p. 551, doi. 10.1007/s00011-016-0939-9

By:

Lv, Manhua;
Zhang, Dayong;
Dai, Dawei;
Zhang, Wei;
Zhang, Liming

Publication type:

Article

The Role of Sphingolipid Metabolism in Pregnancy-Associated Breast Cancer After Chemotherapy.

Published in:

Biomedicines, 2024, v. 12, n. 12, p. 2843, doi. 10.3390/biomedicines12122843

By:

Blokhin, Victor;
Zavarykina, Tatiana;
Kotsuba, Vasily;
Kapralova, Maria;
Gutner, Uliana;
Shupik, Maria;
Kozyrko, Elena;
Luzina, Evgenia;
Lomskova, Polina;
Bajgazieva, Darya;
Khokhlova, Svetlana;
Alessenko, Alice

Publication type:

Article

Efficacy of a Multi-lamellar Emulsion Containing a Synthetic Sphingosine Kinase 1 Activator and Pseudoceramide in Patients with Atopic Dermatitis: A Randomized Controlled Trial.

Published in:

Dermatology & Therapy, 2024, v. 14, n. 9, p. 2591, doi. 10.1007/s13555-024-01254-5

By:

Lee, So Yeon;
Park, Jin Seo;
Kim, Daehwan;
Jeong, Wonseok;
Hwang, Chenghwan;
Kim, Hye One;
Park, Chun Wook;
Chung, Bo Young

Publication type:

Article

Erythrocyte sphingosine kinase regulates intraerythrocytic development of Plasmodium falciparum.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-020-80658-7

By:

Sah, Raj Kumar;
Pati, Soumya;
Saini, Monika;
Singh, Shailja

Publication type:

Article

K27Q/K29Q mutations in sphingosine kinase 1 attenuate high-fat diet induced obesity and altered glucose homeostasis in mice.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-77096-w

By:

Xie, Jing;
Shao, Yong;
Liu, Jin;
Cui, Meilan;
Xiao, Xiuxiao;
Gong, Jingbo;
Xue, Binghua;
Zhang, Qunwei;
Hu, Xianwen;
Duan, Haifeng

Publication type:

Article

Venetoclax resistance induced by activated T cells can be counteracted by sphingosine kinase inhibitors in chronic lymphocytic leukemia.

Published in:

Frontiers in Oncology, 2023, v. 13, p. 1, doi. 10.3389/fonc.2023.1143881

By:

Martinez, Valeria J. Sarapura;
Buonincontro, Brenda;
Cassarino, Chiara;
Bernatowiez, Juliana;
Colado, Ana;
Cordini, Gregorio;
Custidiano, Maria del Rosario;
Mahuad, Carolina;
Pavlovsky, Miguel A.;
Bezares, Raimundo F.;
Favale, Nicolás O.;
Vermeulen, Mónica;
Borge, Mercedes;
Giordano, Mirta;
Gamberale, Romina

Publication type:

Article