Title: Cellular Superspreaders: An Epidemiological Perspective on HIV Infection inside the Body.
Authors: Talbert-Slagle, Kristina; Atkins, Katherine E.; Yan, Koon-Kiu; Khurana, Ekta; Gerstein, Mark; Bradley, Elizabeth H.; Berg, David; Galvani, Alison P.; Townsend, Jeffrey P.
Abstract: The authors describe evidence from molecular biology and virology suggesting that CD4 T cell heterogeneity could yield variation in the capability of individual cells to become infected and transmit HIV to other cells. They suggest that the CD4 T cells heterogeneity in the genital mucosa could help explain the low infection-to-exposure ratio and selection of the founder strain after sexual exposure to HIV. They also investigate the existence of cellular HIV superspreaders.
Subjects: T cells; CD4 antigen; HIV; HIV infection transmission; MOLECULAR virology
Publication: PLoS Pathogens, 2014, Vol 10, Issue 5, p1
ISSN: 1553-7366
Publication type: Academic Journal
DOI: 10.1371/journal.ppat.1004092

Cellular Superspreaders: An Epidemiological Perspective on HIV Infection inside the Body.

Talbert-Slagle, Kristina; Atkins, Katherine E.; Yan, Koon-Kiu; Khurana, Ekta; Gerstein, Mark; Bradley, Elizabeth H.; Berg, David; Galvani, Alison P.; Townsend, Jeffrey P.