Works matching DE "DRUG repositioning"

Results: 1913

Drugs to the Rescue: Comparison of On-Demand Therapies for OFF Symptoms in Parkinson's Disease.

Published in:

Journal of Parkinson's Disease, 2023, v. 13, n. 4, p. 441, doi. 10.3233/JPD-230055

By:

Martinez-Nunez, Alfonso E.;
LeWitt, Peter A.

Publication type:

Article

Trapidil attenuates diabetic cardiomyopathy via GPX3/Nrf2-mediated inhibition of myocardial pyroptosis.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1566622

By:

Wang, Zihao;
Sun, Yingzi;
Wang, Juanjuan;
Xu, Qiuyue;
Wang, Liuxing;
Zhang, Qi;
Song, Juan;
Wang, Yuchun;
Qi, Zhanpeng

Publication type:

Article

Repurposing FDA-approved drugs to find a novel inhibitor of alpha-ketoglutarate-dependent dioxygenase FTO to treat esophageal cancer.

Published in:

Research in Pharmaceutical Sciences, 2025, v. 20, n. 3, p. 392, doi. 10.4103/RPS.RPS_9_25

By:

Mohammadi, Zeinab;
Jazi, Marie Saghaeian;
Jafari, Seyyed Mehdi;
Mir, Seyyed Mostafa;
Asadi, Jahanbakhsh;
Amanlou, Massoud

Publication type:

Article

Drug repositioning for pan-cancers of the digestive system: Identification of amonafide and BX795 as potential therapeutics via integrative Omics analysis.

Published in:

PLoS ONE, 2025, v. 20, n. 6, p. 1, doi. 10.1371/journal.pone.0325700

By:

Liu, Weidong;
Gao, Jiaying;
Ren, Shuqiang;
Nashun, Buhe;
Gao, Fei

Publication type:

Article

Drug repurposing of fostamatinib against cancer via potential cytotoxicity and immune checkpoint regulation.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1602189

By:

Hu, Maoqiong;
Yin, Renyi;
Deng, Kaifeng;
Xu, Ning

Publication type:

Article

Sepsis Important Genes Identification Through Biologically Informed Deep Learning and Transcriptomic Analysis.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2025, v. 52, n. 7, p. 1, doi. 10.1111/1440-1681.70031

By:

Li, Ruichen;
Wang, Qiushi;
Gao, Ru;
Shen, Rutao;
Wang, Qihao;
Cui, Xiuliang;
Jiang, Zhiming;
Zhang, Lijie;
Fang, Jingjing

Publication type:

Article

Uncovering New Therapeutic Targets for Amyotrophic Lateral Sclerosis and Neurological Diseases Using Real‐World Data.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 118, n. 1, p. 242, doi. 10.1002/cpt.3682

By:

Alidoost, Mohammadali;
Huang, Jeremy Y.;
Dermentzaki, Georgia;
Blazier, Anna S.;
Gaglia, Giorgio;
Hammond, Timothy R.;
Frau, Francesca;
McCorry, Mary Clare;
Ofengeim, Dimitry;
Wilson, Jennifer L.

Publication type:

Article

Computational Analysis of GPCR Networks in Opioid Use Disorder: From Transcriptomics to Drug Discovery.

Published in:

Pathobiology Research, 2025, v. 28, n. 2, p. 35

By:

Sadr, Narjes Khatoun Shabani;
Mirzaei, Mahsa;
Behmanesh, Mehrdad

Publication type:

Article

Repurposing the memory-promoting meclofenoxate hydrochloride as a treatment for Parkinson's disease through integrative multi-omics analysis.

Published in:

NPJ Parkinson's Disease, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41531-025-01027-7

By:

Zhang, Huasong;
Fan, Cong;
Li, Ling;
Liu, Feiyi;
Li, Shaoying;
Ma, Linyun;
Yang, Yuanhao;
Cooper, David N.;
Yang, Yuedong;
Hu, Ronggui;
Zhao, Huiying

Publication type:

Article

Editorial: Repurposed drugs targeting cancer signaling pathways: clinical insights to improve oncologic therapies, volume II.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1628842

By:

Campos-Parra, Alma D.;
Leyva-Gomez, Gerardo;
Padilla-Benavides, Teresita

Publication type:

Article

Integrative Analysis of Drug Co-Prescriptions in Peritoneal Dialysis Reveals Molecular Targets and Novel Strategies for Intervention.

Published in:

Journal of Clinical Medicine, 2025, v. 14, n. 11, p. 3733, doi. 10.3390/jcm14113733

By:

Evgeniou, Michail;
Perco, Paul;
Eibensteiner, Fabian;
Unterwurzacher, Markus;
Vychytil, Andreas;
Herzog, Rebecca;
Kratochwill, Klaus

Publication type:

Article

Novel Antimicrobials from Computational Modelling and Drug Repositioning: Potential In Silico Strategies to Increase Therapeutic Arsenal Against Antimicrobial Resistance.

Published in:

Molecules, 2025, v. 30, n. 11, p. 2303, doi. 10.3390/molecules30112303

By:

Tarín-Pelló, Antonio;
Fernández-Álvarez, Sara;
Suay-García, Beatriz;
Pérez-Gracia, María Teresa

Publication type:

Article

Primidone: a clinically promising candidate for the treatment of psoriasis.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02552-3

By:

Riebeling, Theresa;
Kolbrink, Benedikt;
Philippsen, Rebecca;
Dahlke, Eileen;
Delanghe, Tom;
Theilig, Franziska;
Schwarz, Agatha;
Schmitt, Roland;
Bertrand, Mathieu J. M.;
Kunzendorf, Ulrich;
Krautwald, Stefan

Publication type:

Article

Znaczenie i perspektywy stosowania leków przeciwdepresyjnych w adjuwantowej terapii glejaka.

Published in:

Advances in Biochemistry / Postepy Biochemii, 2025, v. 71, n. 1, p. 79, doi. 10.18388/pb.2021_602

By:

Grabowska, Agata;
BieleckaWajdman, Anna

Publication type:

Article

Multifunctional Pyrazolo[3,4-d]Pyrimidine Analogs (HCQ-PPs): Design, Synthesis and Anti-SARS-CoV-2 Evaluation.

Published in:

Polycyclic Aromatic Compounds, 2025, v. 45, n. 4, p. 597, doi. 10.1080/10406638.2024.2413429

By:

Alseud, Khaled;
Abou-Salim, Mahrous A.

Publication type:

Article

Epigenetic Therapies in Melanoma—Targeting DNA Methylation and Histone Modification.

Published in:

Biomedicines, 2025, v. 13, n. 5, p. 1188, doi. 10.3390/biomedicines13051188

By:

Tigu, Adrian Bogdan;
Ivancuta, Andrei;
Uhl, Andrada;
Sabo, Alexandru Cristian;
Nistor, Madalina;
Mureșan, Ximena-Maria;
Cenariu, Diana;
Timis, Tanase;
Diculescu, Doru;
Gulei, Diana

Publication type:

Article

A Unified Framework for Alzheimer's Disease Knowledge Graphs: Architectures, Principles, and Clinical Translation.

Published in:

Brain Sciences (2076-3425), 2025, v. 15, n. 5, p. 523, doi. 10.3390/brainsci15050523

By:

Dobreva, Jovana;
Simjanoska Misheva, Monika;
Mishev, Kostadin;
Trajanov, Dimitar;
Mishkovski, Igor

Publication type:

Article

Biology-Informed Matrix Factorization: An AI-Driven Framework for Enhanced Drug Repositioning.

Published in:

Biology (2079-7737), 2025, v. 14, n. 5, p. 549, doi. 10.3390/biology14050549

By:

Wang, Yangyang;
Wang, Yaping;
Hu, Ya;
Wang, Jihan

Publication type:

Article

Synthesis Methods and Therapeutic Journey of Carprofen and Its Derivatives: A Review.

Published in:

Chemical Biology & Drug Design, 2025, v. 105, n. 5, p. 1, doi. 10.1111/cbdd.70122

By:

Limban, Carmen;
Nuță, Diana Camelia;
Caproiu, Miron Teodor;
Dumitrescu, Denisa Elena;
Papacocea, Șerban Iancu;
Bordei, Alexandra Teodora;
Dumitrașcu, Florea

Publication type:

Article

Crystal structures of the putative endoribonuclease L‐PSP from Entamoeba histolytica.

Published in:

Acta Crystallographica: Section F, Structural Biology Communications, 2025, v. 81, n. 6, p. 226, doi. 10.1107/S2053230X25003875

By:

Ojuromi, Oladele T.;
Giwa, Abdulazeez O.;
Gardberg, Anna;
Subramanian, Sandhya;
Myler, Peter J.;
Abendroth, Jan;
Staker, Bart;
Asojo, Oluwatoyin A.

Publication type:

Article

Repositioning FDA-Approved Sulfonamide-Based Drugs as Potential Carbonic Anhydrase Inhibitors in Trypanosoma cruzi : Virtual Screening and In Vitro Studies.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 669, doi. 10.3390/ph18050669

By:

Ortiz-Pérez, Eyra;
Moreno-Rodríguez, Adriana;
Delgado-Maldonado, Timoteo;
Ortega-Balleza, Jessica L.;
González-González, Alonzo;
Paz-González, Alma D.;
Vázquez, Karina;
Avalos-Navarro, Guadalupe;
Giovannuzzi, Simone;
Supuran, Claudiu T.;
Rivera, Gildardo

Publication type:

Article

Systems Biology-Driven Discovery of Host-Targeted Therapeutics for Oropouche Virus: Integrating Network Pharmacology, Molecular Docking, and Drug Repurposing.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 613, doi. 10.3390/ph18050613

By:

Dev Sharma, Pranab;
Alhudhaibi, Abdulrahman Mohammed;
Al Noman, Abdullah;
Abdallah, Emad M.;
Taha, Tarek H.;
Sharma, Himanshu

Publication type:

Article

Evolution of Antiviral Drug Resistance in SARS-CoV-2.

Published in:

Viruses (1999-4915), 2025, v. 17, n. 5, p. 722, doi. 10.3390/v17050722

By:

Dinata, Roy;
Baindara, Piyush;
Mandal, Santi M.

Publication type:

Article

Prediction of drug-target interactions based on substructure subsequences and cross-public attention mechanism.

Published in:

PLoS ONE, 2025, v. 20, n. 5, p. 1, doi. 10.1371/journal.pone.0324146

By:

Shi, Haikuo;
Hu, Jing;
Zhang, Xiaolong;
Jin, Shuting;
Xu, Xin

Publication type:

Article

P-Glycoprotein as a Therapeutic Target in Hematological Malignancies: A Challenge to Overcome.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4701, doi. 10.3390/ijms26104701

By:

Álvarez-Carrasco, Pablo;
Morales-Villamil, Fernanda;
Maldonado-Bernal, Carmen

Publication type:

Article

The Use of Selective Serotonin Reuptake Inhibitor (SSRI) Antidepressants in the Treatment of Lung Cancer.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4546, doi. 10.3390/ijms26104546

By:

Özkaya Gül, Serap;
Aydemir, Esra

Publication type:

Article

Molecular Dynamics-Guided Repositioning of FDA-Approved Drugs for PD-L1 Inhibition with In Vitro Anticancer Potential.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4497, doi. 10.3390/ijms26104497

By:

Jiang, Dejun;
Yoou, Myoung-Schook;
Cho, Sungjoon;
Choi, Youngjin

Publication type:

Article

Exploring the pathways linking fasting insulin to coronary artery disease: a proteome-wide Mendelian randomization study.

Published in:

BMC Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12916-025-04127-6

By:

Huang, Xin;
Zhao, Jie V.

Publication type:

Article

TrialSieve : A Comprehensive Biomedical Information Extraction Framework for PICO, Meta-Analysis, and Drug Repurposing.

Published in:

Bioengineering (Basel), 2025, v. 12, n. 5, p. 486, doi. 10.3390/bioengineering12050486

By:

Kartchner, David;
Turner, Haydn;
Ye, Christophe;
Al-Hussaini, Irfan;
Nursal, Batuhan;
Lee, Albert J. B.;
Deng, Jennifer;
Curtis, Courtney;
Cho, Hannah;
Duvaris, Eva L.;
Jackson, Coral;
Shanks, Catherine E.;
Tan, Sarah Y.;
Ramalingam, Selvi;
Mitchell, Cassie S.

Publication type:

Article

基于SPO 语义三元组的自闭症谱系障碍药物知识发现.

Published in:

Chinese Nursing Research, 2024, v. 38, n. 5, p. 796, doi. 10.12102/j.issn.1009-6493.2024.05.007

By:

吕艳华;
赵宏霞;
李琦;
梁傲雪;
于琦

Publication type:

Article

Drug Repositioning of Pioglitazone in Management and Improving the Cognitive Function among the Patients With Mild to Moderate Alzheimer's Disease: A Systematic Review and Meta-Analysis.

Published in:

Neurology India, 2023, v. 71, n. 6, p. 1132, doi. 10.4103/0028-3886.391397

By:

Basutkar, Roopa;
Sudarsan, Pooja;
Robin, Sandra;
Bhaskar, Vahini;
Viswanathan, Balasubramaniam;
Sivasankaran, Ponnusankar

Publication type:

Article

Risk factors associated with the onset of lomustine‐induced neutropenia in tumour‐bearing dogs.

Published in:

Veterinary & Comparative Oncology, 2022, v. 20, n. 3, p. 577, doi. 10.1111/vco.12809

By:

Treggiari, Elisabetta;
Cossu, Giovanna;
Valenti, Paola;
Taylor, Angela

Publication type:

Article

Inclusion Complexes of Gold(I)‐Dithiocarbamates with β‐Cyclodextrin: A Journey from Drug Repurposing towards Drug Discovery.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 47, p. 12156, doi. 10.1002/chem.202101366

By:

Morgen, Michael;
Fabrowski, Piotr;
Amtmann, Eberhard;
Gunkel, Nikolas;
Miller, Aubry K.

Publication type:

Article

Repurposing serotonergic drugs for gastric cancer: induction of apoptosis in vitro.

Published in:

Molecular Biology Reports, 2025, v. 52, n. 1, p. 1, doi. 10.1007/s11033-025-10474-7

By:

Abedini, Fatemeh;
Amjadi, Omolbanin;
Ahangari, Ghasem

Publication type:

Article

A complex bearing TSPO PIGA ligand coordinated to the [Au(PEt<sub>3</sub>)]<sup>+</sup> pharmacophore is highly cytotoxic against ovarian cancer cells.

Published in:

BioMetals, 2023, v. 36, n. 5, p. 961, doi. 10.1007/s10534-023-00496-8

By:

Chiaverini, Lorenzo;
Baglini, Emma;
Mannelli, Michele;
Poggetti, Valeria;
Da Settimo, Federico;
Taliani, Sabrina;
Gamberi, Tania;
Barresi, Elisabetta;
La Mendola, Diego;
Marzo, Tiziano

Publication type:

Article

Fenamates: Forgotten treasure for cancer treatment and prevention: Mechanisms of action, structural modification, and bright future.

Published in:

2025

By:

Li, Junfang;
Wang, Xiaodong;
Zhang, Honghua;
Hu, Xiaoling;
Peng, Xue;
Jiang, Weifan;
Zhuo, Linsheng;
Peng, Yan;
Zeng, Guo;
Wang, Zhen

Publication type:

Literature Review

Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies.

Published in:

Medicinal Research Reviews, 2024, v. 44, n. 5, p. 2078, doi. 10.1002/med.22033

By:

Das, Viswanath;
Miller, John H.;
Alladi, Charanraj Goud;
Annadurai, Narendran;
De Sanctis, Juan Bautista;
Hrubá, Lenka;
Hajdúch, Marián

Publication type:

Article

Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics.

Published in:

Medicinal Research Reviews, 2022, v. 42, n. 4, p. 1704, doi. 10.1002/med.21889

By:

Gong, Shilin;
Hu, Xiaolan;
Chen, Shengshuang;
Sun, Baoqing;
Wu, Jian‐Lin;
Li, Na

Publication type:

Article

Haste makes waste: A critical review of docking‐based virtual screening in drug repurposing for SARS‐CoV‐2 main protease (M‐pro) inhibition.

Published in:

Medicinal Research Reviews, 2022, v. 42, n. 2, p. 744, doi. 10.1002/med.21862

By:

Macip, Guillem;
Garcia‐Segura, Pol;
Mestres‐Truyol, Júlia;
Saldivar‐Espinoza, Bryan;
Ojeda‐Montes, María José;
Gimeno, Aleix;
Cereto‐Massagué, Adrià;
Garcia‐Vallvé, Santiago;
Pujadas, Gerard

Publication type:

Article

Natural products as geroprotectors: An autophagy perspective.

Published in:

Medicinal Research Reviews, 2021, v. 41, n. 6, p. 3118, doi. 10.1002/med.21815

By:

Raj, Stephen D.;
Fann, David Y.;
Wong, Esther;
Kennedy, Brian K.

Publication type:

Article

Recent pharmacological advances in the repurposing of artemisinin drugs.

Published in:

Medicinal Research Reviews, 2021, v. 41, n. 6, p. 3156, doi. 10.1002/med.21837

By:

Meng, Yuqing;
Ma, Nan;
Lyu, Haining;
Wong, Yin Kwan;
Zhang, Xing;
Zhu, Yongping;
Gao, Peng;
Sun, Peng;
Song, Yali;
Lin, Lizhu;
Wang, Jigang

Publication type:

Article

How to make the best of NLRP3 inhibitors in patients with COVID-19?

Published in:

2023

By:

Kow, Chia Siang;
Ramachandram, Dinesh Sangarran;
Hasan, Syed Shahzad

Publication type:

Letter to the Editor

Drug repositioning in the COVID-19 pandemic: fundamentals, synthetic routes, and overview of clinical studies.

Published in:

European Journal of Clinical Pharmacology, 2023, v. 79, n. 6, p. 723, doi. 10.1007/s00228-023-03486-4

By:

Vaz, Elisa Souza;
Vassiliades, Sandra Valeria;
Giarolla, Jeanine;
Polli, Michelle Carneiro;
Parise-Filho, Roberto

Publication type:

Article

Emerging therapeutic strategies in glioblastsoma: drug repurposing, mechanisms of resistance, precision medicine, and technological innovations.

Published in:

Clinical & Experimental Medicine, 2025, v. 25, n. 1, p. 1, doi. 10.1007/s10238-025-01631-0

By:

Anwer, Mohamed S.;
Abdel-Rasol, Mohammed A.;
El-Sayed, Wael M.

Publication type:

Article

Hunting the main protease of SARS-CoV-2 by plitidepsin: Molecular docking and temperature-dependent molecular dynamics simulations.

Published in:

Amino Acids, 2022, v. 54, n. 2, p. 205, doi. 10.1007/s00726-021-03098-1

By:

Vishvakarma, Vijay Kumar;
Singh, Madhur Babu;
Jain, Pallavi;
Kumari, Kamlesh;
Singh, Prashant

Publication type:

Article

New and Repurposed Drugs for the Treatment of Active Tuberculosis: An Update for Clinicians.

Published in:

Respiration, 2023, v. 102, n. 2, p. 83, doi. 10.1159/000528274

By:

Aguilar Diaz, Jessica M;
Abulfathi, Ahmed A;
te Brake, Lindsey HM;
van Ingen, Jakko;
Kuipers, Saskia;
Magis-Escurra, Cecile;
Raaijmakers, Jelmer;
Svensson, Elin M;
Boeree, Martin J

Publication type:

Article

Revamped role for approved drug: integrative computational and biophysical analysis of saquinavir's peptidyl arginine deiminase 4 inhibition for rheumatoid arthritis.

Published in:

Biochemical Journal, 2024, v. 481, n. 20, p. 1379, doi. 10.1042/BCJ20240366

By:

Thirugnanasambandham, Indhumathi;
Jupudi, Srikanth;
Roychowdhury, Parikshit;
Reddy Karri, Veera Venkata Satyanarayana;
Madhunapantula, Subba Rao V.;
Singh, Sachin Kumar;
Subramaniyan, Vetriselvan;
Kuppusamy, Gowthamarajan

Publication type:

Article

Polypharmacological repurposing approach identifies approved drugs as potential inhibitors of Mycobacterium tuberculosis.

Published in:

Biochemical Journal, 2023, v. 480, n. 14, p. 1079, doi. 10.1042/BCJ20230143

By:

Singh, Jasdeep;
Quadir, Neha;
Vashishtha, Shubham;
Chakraborty, Ankan;
Alam, Anwar;
Kundu, Bishwajit;
Ahmad, Uzair;
Sundar, Durai;
Ehtesham, Nasreen Z.;
Hasnain, Seyed E.

Publication type:

Article

REPURPOSING EMPAGLIFLOZIN TO TREAT NEUTROPENIA IN A TURKISH GIRL WITH GLYCOGEN STORAGE DISEASE TYPE 1B.

Published in:

Turkish Medical Student Journal, 2024, v. 11, n. 2, p. 50, doi. 10.4274/tmsj.galenos.2024.2024-2-1

By:

Özkan, Hasan Selçuk;
Aydın, Ece Derin;
Mammadova, Sakina;
Çoker, Mahmut

Publication type:

Article

Anticancer effect of the antirheumatic drug leflunomide on oral squamous cell carcinoma by the inhibition of tumor angiogenesis.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-01763-5

By:

Niwata, Chieko;
Nakagawa, Takayuki;
Naruse, Takako;
Sakuma, Miyuki;
Yamakado, Nao;
Akagi, Misaki;
Ono, Shigehiro;
Tobiume, Kei;
Gao, Jing;
Jimi, Eijiro;
Ohta, Kouji;
Aikawa, Tomonao

Publication type:

Article