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- Title
Association between age at first birth and risk of rheumatoid arthritis in women: Evidence from NHANES 2011–2020.
- Authors
Cui, Hang; Huang, Chenyang; Ye, Yuntian; Guo, Tianci; Yu, Weijie; Niu, Puyu; Gao, Kuiliang; Liu, Jiajin; Liu, Aifeng
- Abstract
Objective: This study focused on investigating the relation of age at first birth (AFB) with rheumatoid arthritis (RA) risk in women based on the 2011–2020 NHANES (National Health and Nutrition Examination Survey) data. Methods: Women were analyzed using National Health and Nutrition Examination Survey (NHANES) data from 2011 to 2020 in the US. Both AFB and RA diagnoses were obtained through self-reported questionnaires. Odds ratios (ORs) and 95% confidence intervals (CIs) were determined using logistic regression models. Results: Among the 7,449 women included in this study, 552 (7%) were diagnosed with RA. In comparison with women who had an AFB of 30–32 years (reference group), those who had an AFB < 18, 18–20, 21–23, 24–26, and > 35 years had the fully adjusted ORs and 95% CIs of 4.00 (95% CI 1.70, 9.40), 2.90 (95% CI 1.25, 6.73), 3.00 (95% CI 1.32, 6.80), 3.18 (95% CI 1.36–7.42), and 3.36 (95% CI 1.04–10.7), respectively. Due to the limitations inherent in cross-sectional studies, we have not observed significant differences in the risk of RA between women aged 27–29 and 33–35 at the AFB. Further research is warranted to refine these findings. Conclusion: Women with an AFB < 26, or > 35 years have a higher risk of developing RA later in life. Policymakers may consider focusing more on women in these AFB age ranges in screening RA and making preventive measures.
- Subjects
NATIONAL Health & Nutrition Examination Survey; RHEUMATOID arthritis; LOGISTIC regression analysis; ODDS ratio; CROSS-sectional method
- Publication
PLoS ONE, 2025, Vol 20, Issue 1, p1
- ISSN
1932-6203
- Publication type
Academic Journal
- DOI
10.1371/journal.pone.0317443