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- Title
Clinical outcomes and anti-inflammatory mechanisms predict maximum heart rate improvement after physical activity training in individuals with psychiatric disorders and comorbid obesity.
- Authors
Soldevila-Matías, Pau; Sánchez-Ortí, Joan Vicent; Correa-Ghisays, Patricia; Balanzá-Martínez, Vicent; Selva-Vera, Gabriel; Sanchis-Sanchis, Roberto; Iglesias-García, Néstor; Monfort-Pañego, Manuel; Tomás-Martínez, Pilar; Victor, Víctor M.; Crespo-Facorro, Benedicto; Valenzuela, Constanza San Martin; Climent-Sánchez, José Antonio; Corral-Márquez, Rosana; Fuentes-Durá, Inmaculada; Tabarés-Seisdedos, Rafael
- Abstract
Introduction: This study aimed to evaluate the predictive validity and discriminatory ability of clinical outcomes, inflammatory activity, oxidative and vascular damage, and metabolic mechanisms for detecting significant improve maximum heart rate after physical activity training in individuals with psychiatric disorders and obesity comorbid using a longitudinal design and transdiagnostic perspective. Methods: Patients with major depressive disorder, bipolar disorder and, schizophrenia and with comorbid obesity (n = 29) were assigned to a 12-week structured physical exercise program. Peripheral blood biomarkers of inflammation, oxidative stress, vascular mechanisms, and metabolic activity, as well as neurocognitive and functional performance were assessed twice, before and after intervention. Maximum heart rate was considered a marker of effectiveness of physical activity. Mixed one-way analysis of variance and linear regression analyses were performed. Results: Individuals with psychiatric disorders and comorbid obesity exhibited an improvement in cognition, mood symptoms and body mass index, increase anti-inflammatory activity together with enhancement of the oxidative and cardiovascular mechanisms after physical activity training (p2 = 32.2 to 39.0, p < 0.0001). Conclusions: The regulation of the anti-inflammatory mechanisms may be essential for maintained of healthy physical activity across psychiatric disorders and obesity. Likewise, inflammatory activity, oxidative stress, vascular and cardio-metabolic mechanisms may be a useful to identify individuals at greater risk of multi-comorbidity.
- Subjects
MENTAL depression; ONE-way analysis of variance; MENTAL illness; HEART beat; BODY mass index
- Publication
PLoS ONE, 2025, Vol 20, Issue 1, p1
- ISSN
1932-6203
- Publication type
Academic Journal
- DOI
10.1371/journal.pone.0313759