Works matching DE "CYTOCHROME P-450 CYP3A"

Results: 715

Auto-Induction in Oral Esketamine Treatment for Treatment-Resistant Depression: An Exploratory Study.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 627, doi. 10.3390/ph18050627

By:

Veraart, Jolien K. E.;
Vos, Cornelis F.;
Punt, Nieko C.;
Visser, Dylan;
Wessels, Mireille A.;
Smith-Apeldoorn, Sanne Y.;
Kamphuis, Jeanine;
Schoevers, Robert A.;
Touw, Daan J.

Publication type:

Article

Analysis of the Genetic Characteristics and Metastatic Pathways of G1 and G2 Colorectal Neuroendocrine Neoplasms.

Published in:

Journal of the Endocrine Society, 2024, v. 8, n. 2, p. 1, doi. 10.1210/jendso/bvad168

By:

Wang, Zhijie;
Chen, Qichen;
Zhao, Fuqiang;
Sun, Li;
Qiu, Yixian;
Cheng, Huanqing;
Qin, Jiayue;
Wang, Huina;
Shi, Susheng;
Cao, Shanbo;
Liu, Qian

Publication type:

Article

Solifenacin.

Published in:

SA Pharmaceutical Journal Incorporating Pharmacy Management, 2023, v. 90, n. 1, p. 35

By:

Rabbets, W.

Publication type:

Article

Metabolism of m-CPP, trazodone, nefazodone, and etoperidone: clinical and forensic aspects.

Published in:

Drug Metabolism Reviews, 2025, v. 57, n. 2, p. 115, doi. 10.1080/03602532.2025.2465482

By:

Costa Alegre, Mariana Duarte;
Barbosa, Daniel José;
Dinis-Oliveira, Ricardo Jorge

Publication type:

Article

Insights into oral bioavailability enhancement of therapeutic herbal constituents by cytochrome P450 3A inhibition.

Published in:

Drug Metabolism Reviews, 2021, v. 53, n. 4, p. 491, doi. 10.1080/03602532.2021.1917598

By:

Chen, Junmei;
Liu, Jinman;
Huang, Yueyue;
Li, Ruoyu;
Ma, Cuiru;
Zhang, Beiping;
Wu, Fanchang;
Yu, Wenqian;
Zuo, Xue;
Liang, Yong;
Wang, Qi

Publication type:

Article

Evaluation of machine learning models for cytochrome P450 3A4, 2D6, and 2C9 inhibition.

Published in:

Journal of Applied Toxicology, 2024, v. 44, n. 7, p. 1050, doi. 10.1002/jat.4601

By:

Gong, Changda;
Feng, Yanjun;
Zhu, Jieyu;
Liu, Guixia;
Tang, Yun;
Li, Weihua

Publication type:

Article

Physiologically based pharmacokinetic modeling for confirming the role of CYP3A1/2 and P‐glycoprotein in detoxification mechanism between glycyrrhizic acid and aconitine in rats.

Published in:

Journal of Applied Toxicology, 2024, v. 44, n. 7, p. 978, doi. 10.1002/jat.4595

By:

Jin, Jingyi;
Xu, Xiaoqing;
Li, Fengling;
Weng, Fengyi;
Zou, Bin;
Li, Yue;
Zhao, Jing;
Zhang, Shuang;
Yan, Dongming;
Qiu, Furong

Publication type:

Article

Nitrophenols disrupt the expression and activity of biotransformation enzymes (CYP3A and COMT) in chicken ovarian follicles in vivo and in vitro.

Published in:

Journal of Applied Toxicology, 2024, v. 44, n. 5, p. 756, doi. 10.1002/jat.4573

By:

Kozubek, Anna;
Katarzyńska‐Banasik, Dorota;
Kowalik, Kinga;
Grzegorzewska, Agnieszka K.;
Hrabia, Anna;
Sechman, Andrzej

Publication type:

Article

Boscalid shows increased thyroxin‐glucuronidation in rat but not in human hepatocytes in vitro.

Published in:

Journal of Applied Toxicology, 2023, v. 43, n. 6, p. 828, doi. 10.1002/jat.4427

By:

Wiemann, Christiane;
Melching‐Kollmuss, Stephanie;
Hambruch, Nina;
Wiss, Lucille;
Stauber, Franz;
Richert, Lysiane

Publication type:

Article

阿尔茨海默病患外周血和海马区中铜 /铁蛋白及核心基因的生物信息学分析.

Published in:

Journal of Central China Normal University, 2024, v. 58, n. 5, p. 542, doi. 10.19603/j.cnki.1000-1190.2024.05.006

By:

张慧琼;
张倩;
陈红安;
江南

Publication type:

Article

Induction of CYP3A activity by dexamethasone may not be strong, even at high doses: insights from a case of tacrolimus co-administration.

Published in:

Journal of Pharmaceutical Health Care & Sciences, 2023, v. 9, n. 1, p. 1, doi. 10.1186/s40780-023-00310-0

By:

Ohno, Yoshiyuki;
Oriyama, Toyohito;
Honda, Akira;
Kurokawa, Mineo;
Takada, Tappei

Publication type:

Article

A case of complete atrioventricular block with extremely high blood concentration of azelnidipine.

Published in:

Journal of Pharmaceutical Health Care & Sciences, 2021, v. 7, n. 1, p. 1, doi. 10.1186/s40780-021-00230-x

By:

Ide, Naohito;
Mochizuki, Ayaka;
Kagawa, Yoshiyuki;
Ito, Masaharu

Publication type:

Article

Capillary Sampling Enables Venetoclax Concentration Measurement in Acute Myeloid Leukaemia Within Academic Multicentre Trial.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2025, v. 136, n. 6, p. 1, doi. 10.1111/bcpt.70041

By:

Kytölä, Sari;
Kurkela, Mika;
Kiiski, Johanna I.;
Vänttinen, Ida;
Ruokoranta, Tanja;
Partanen, Anu;
Holopainen, Annasofia;
Pyörälä, Marja;
Kuusisto, Milla E. L.;
Siitonen, Timo;
Koskela, Sirpa;
Rimpiläinen, Johanna;
Ettala, Pia;
Kuusanmäki, Heikki;
Niemi, Mikko;
Backman, Janne T.;
Kontro, Mika

Publication type:

Article

Improving CYP2C19 phenotyping using stereoselective omeprazole and 5‐hydroxy‐omeprazole metabolic ratios.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2024, v. 135, n. 6, p. 755, doi. 10.1111/bcpt.14095

By:

Abouir, Kenza;
Varesio, Emmanuel;
Déglon, Julien;
Samer, Caroline;
Daali, Youssef

Publication type:

Article

In vitro assessments predict that CYP3A4 contributes to a greater extent than CYP3A5 to prednisolone clearance.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2021, v. 129, n. 6, p. 427, doi. 10.1111/bcpt.13645

By:

Skauby, Ragnhild Heier;
Bergan, Stein;
Andersen, Anders M.;
Vethe, Nils Tore;
Christensen, Hege

Publication type:

Article

Impact of CYP3A5 genotype on tolvaptan pharmacokinetics and their relationships with endogenous markers of CYP3A activity and serum sodium level in heart failure patients.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2020, v. 126, n. 4, p. 353, doi. 10.1111/bcpt.13355

By:

Hoshikawa, Kohei;
Naito, Takafumi;
Akutsu, Shunta;
Saotome, Masao;
Maekawa, Yuichiro;
Kawakami, Junichi

Publication type:

Article

Therapeutic drug monitoring of docetaxel administered for breast cancer in a patient receiving rifampicin and clarithromycin to treat nontuberculous mycobacteriosis: A case report.

Published in:

2025

By:

Yashima, Hideaki;
Araki, Takuya;
Ishikawa, Yuya;
Ohshima, Sohei;
Nagano, Daisuke;
Obayashi, Kyoko;
Horiguchi, Jun;
Yamamoto, Koujirou

Publication type:

Case Study

Inhibition of phase-1 biotransformation and cytostatic effects of diphenyleneiodonium on hepatoblastoma cell line HepG2 and a CYP3A4-overexpressing HepG2 cell clone.

Published in:

Clinical Hemorheology & Microcirculation, 2021, v. 79, n. 1, p. 231, doi. 10.3233/CH-219117

By:

Schulz, Christian;
Jung, Friedrich;
Küpper, Jan-Heiner;
Küpper, J.-H.;
Krüger-Genge, A.;
Jung, F.

Publication type:

Article

Hepatic CYP3A4 Enzyme Compensatively Maintains Endogenous Geranylgeranoic Acid Levels in MAOB -Knockout Human Hepatoma Cells.

Published in:

Metabolites (2218-1989), 2022, v. 12, n. 2, p. N.PAG, doi. 10.3390/metabo12020140

By:

Tabata, Yuki;
Shidoji, Yoshihiro

Publication type:

Article

Pilot studies of vonoprazan‐containing Helicobacter pylori eradication therapy suggest Thailand may be more similar to the US than Japan.

Published in:

Helicobacter, 2023, v. 28, n. 6, p. 1, doi. 10.1111/hel.13019

By:

Ratana‐Amornpin, Sarita;
Sanglutong, Likasith;
Eiamsitrakoon, Thanee;
Siramolpiwat, Sith;
Graham, David Y.;
Mahachai, Varocha

Publication type:

Article

Unravelling the pharmacokinetics of aflatoxin B1: In vitro determination of Michaelis-Menten constants, intrinsic clearance and the metabolic contribution of CYP1A2 and CYP3A4 in pooled human liver microsomes.

Published in:

Frontiers in Microbiology, 2022, v. 13, p. 1, doi. 10.3389/fmicb.2022.988083

By:

Looten, Orphélie;
De Boevre, Marthe;
Gasthuys, Elke;
Van Bocxlaer, Jan;
Vermeulen, An;
De Saeger, Sarah

Publication type:

Article

Rhabdomyolysis Risk: The Dangers of Tribulus terrestris, an Over-the-Counter Supplement.

Published in:

2024

By:

Huff, Ross;
Karpinska-Leydier, Katarzyna;
Maddineni, Gautam;
Begosh-Mayne, Dustin

Publication type:

Case Study

A Narrative Review of Statin-Induced Rhabdomyolysis: Molecular Mechanism, Risk Factors, and Management.

Published in:

Drug, Healthcare & Patient Safety, 2021, v. 13, p. 211, doi. 10.2147/DHPS.S333738

By:

Safitri, Nisa;
Alaina, Maya Fadila;
Pitaloka, Dian Ayu Eka;
Abdulah, Rizky

Publication type:

Article

Evaluation of the Pharmacokinetics of Trazpiroben (TAK-906), a Peripherally Selective D2/D3 Dopamine Receptor Antagonist, in the Presence and Absence of Itraconazole, a Potent CYP 3A4 Inhibitor.

Published in:

Clinical Pharmacology, 2021, v. 13, p. 145, doi. 10.2147/CPAA.S310609

By:

Chen, Chunlin;
Zhang, Wenwen;
Bari, Muhammad;
Almansa, Cristina;
Baratta, Mike;
Rosario, Maria

Publication type:

Article

Association of CYP3A4-392A/G, CYP3A5-6986A/G, and ABCB1-3435C/T Polymorphisms with Tacrolimus Dose, Serum Concentration, and Biochemical Parameters in Mexican Patients with Kidney Transplant.

Published in:

Genes, 2024, v. 15, n. 4, p. 497, doi. 10.3390/genes15040497

By:

Alatorre-Moreno, Edith Viridiana;
Saldaña-Cruz, Ana Miriam;
Pérez-Guerrero, Edsaúl Emilio;
Morán-Moguel, María Cristina;
Contreras-Haro, Betsabé;
López-de La Mora, David Alejandro;
Dávalos-Rodríguez, Ingrid Patricia;
Marín-Medina, Alejandro;
Rivera-Cameras, Alicia;
Balderas-Peña, Luz-Ma Adriana;
Gómez-Ramos, José Juan;
Cortés-Sanabria, Laura;
Salazar-Páramo, Mario

Publication type:

Article

CYP3A5 Polymorphism in Circulating Tumor Cells Confers an Increased Disease-Free Survival in DLBCL Patients Treated with R-CHOP.

Published in:

OncoTargets & Therapy, 2025, v. 18, p. 355, doi. 10.2147/OTT.S486400

By:

Maldonado, Rafael Cerón;
Tovar, Adolfo Martínez;
Peñafiel, Christian Omar Ramos;
De la Cruz Rosas, Adrián;
Laguna, Anel Irais García;
Salas, Iveth Mendoza;
Murillo, Carlos Martínez;
Lampón, Gilberto Israel Barranco;
Figueroa, Efreen Horacio Montaño;
Jiménez-Morales, Silvia;
Carrillo, Irma Olarte

Publication type:

Article

INSIGHTS INTO CLOZAPINE'S KINETIC INTERACTIONS: ENZYMATIC INHIBITION OF CYP1A2 BY CIPROFLOXACIN AND NORFLOXACIN.

Published in:

Studia Universitatis Babes-Bolyai, Chemia, 2024, v. 69, n. 4, p. 99, doi. 10.24193/subbchem.2024.4.07

By:

CHIRALI, Ana-Elena;
CIOCOTIȘAN, Iulia Maria;
VLASE, Ana-Maria;
MUNTEAN, Dana Maria;
VLASE, Laurian

Publication type:

Article

Influence of CYP2D6, CYP2C19 and CYP3A5 polymorphisms on plasma levels of tamoxifen metabolites in Algerian women with ER+ breast cancer.

Published in:

Egyptian Journal of Medical Human Genetics, 2022, v. 23, n. 1, p. 1, doi. 10.1186/s43042-022-00332-7

By:

Boucenna, Amira;
Boudaoud, Khadidja;
Hireche, Ahmed;
Rezgoune, Mohamed Larbi;
Abadi, Noureddine;
Filali, Taha;
Satta, Dalila

Publication type:

Article

Prevalence and Management of Medication Interactions with Nirmatrelvir-Ritonavir at a Large Urban Academic Medical Center: An Observational Study.

Published in:

2024

By:

Spetko, Nicholas;
Wang, Brianna X.;
Herzig, Shoshana J.;
Anderson, Timothy S.

Publication type:

Letter

Effects of CYP3A5 polymorphism and renal impairment on the drug interaction between venetoclax and fluconazole in acute myeloid leukaemia patients.

Published in:

Xenobiotica, 2025, v. 55, n. 1, p. 37, doi. 10.1080/00498254.2024.2442431

By:

Kobayashi, Takahiro;
Sato, Honami;
Akamine, Yumiko;
Fukushi, Yayoi;
Takahashi, Naoto;
Miura, Masatomo

Publication type:

Article

Potential influence of interleukin-6 -174G/C gene polymorphism on kidney graft function and tacrolimus dose requirements: five-year follow-up.

Published in:

Xenobiotica, 2024, v. 54, n. 10, p. 855, doi. 10.1080/00498254.2024.2427032

By:

Danković, Katarina;
Stefanović, Nikola;
Cvetković, Tatjana;
Vujić, Stevan;
Jović, Maša;
Mitić, Branka;
Veličković-Radovanović, Radmila

Publication type:

Article

Rehmannioside A inhibits the activity of CYP3A4, 2C9 and 2D6 in vitro.

Published in:

Xenobiotica, 2024, v. 54, n. 4, p. 195, doi. 10.1080/00498254.2024.2321969

By:

Wang, Congrong;
Zhou, Naixiang;
Li, Mingcui;
Chen, Haixia

Publication type:

Article

mRNA expression levels of cytochrome P450 CYP1A2, CYP3A4, and CYP3A5 in the epidermis: a focus on individual differences among Japanese individuals.

Published in:

Xenobiotica, 2024, v. 54, n. 5, p. 226, doi. 10.1080/00498254.2024.2344664

By:

Makihara, Hiroko;
Maezawa, Mika;
Kaiga, Kazusa;
Satake, Toshihiko;
Muto, Mayu;
Tsunoda, Yui;
Shimada, Tsutomu;
Akase, Tomoko

Publication type:

Article

The metabolism of the orexin-1 selective receptor antagonist nivasorexant.

Published in:

Xenobiotica, 2024, v. 54, n. 3, p. 124, doi. 10.1080/00498254.2024.2319811

By:

Treiber, Alexander;
Seeland, Swen;
Haschimi, Belal;
Weigel, Aude;
Williams, Jodi T.;
Gabillet, Jerome

Publication type:

Article

High-throughput assay to simultaneously evaluate activation of CYP3A and the direct and time-dependent inhibition of CYP3A, CYP2C9, and CYP2D6 using liquid chromatography-tandem mass spectrometry.

Published in:

Xenobiotica, 2024, v. 54, n. 2, p. 45, doi. 10.1080/00498254.2024.2308818

By:

Yumoto, Yu;
Endo, Takuro;
Harada, Hiroshi;
Kobayashi, Kaoru;
Nakabayashi, Takeshi;
Abe, Yoshikazu

Publication type:

Article

Effect of tubeimoside I on the activity of cytochrome P450 enzymes in human liver microsomes.

Published in:

Xenobiotica, 2024, v. 54, n. 2, p. 57, doi. 10.1080/00498254.2023.2301352

By:

Wang, Rui;
Zheng, Kai;
Liu, Yunjiao;
Ji, Shuxia;
Tang, Yaxin;
Wang, Jie;
Jiang, Rong

Publication type:

Article

Physiologically based pharmacokinetic modelling to predict drug–drug interactions for encorafenib. Part I. Model building, validation, and prospective predictions with enzyme inhibitors, inducers, and transporter inhibitors.

Published in:

Xenobiotica, 2023, v. 53, n. 5, p. 366, doi. 10.1080/00498254.2023.2250856

By:

Kollipara, Sivacharan;
Ahmed, Tausif;
Praveen, Sivadasu

Publication type:

Article

Metabolite profiling and identification of enzymes responsible for the metabolism of hirsutine, a major alkaloid from Uncaria rhynchophylla.

Published in:

Xenobiotica, 2023, v. 53, n. 6/7, p. 474, doi. 10.1080/00498254.2023.2269417

By:

Guo, Yiqing;
Lv, Huanhuan;
Lv, Jing;
Jiang, Zenghong

Publication type:

Article

Danazol increases the oral bioavailability of midazolam by inactivation of hepatic and intestinal CYP3A in rats.

Published in:

Xenobiotica, 2023, v. 53, n. 5, p. 421, doi. 10.1080/00498254.2023.2253314

By:

Fukuno, Shuhei;
Nagai, Katsuhito;
Kurotobi, Akemi;
Sahori, Yuki;
Nakagawa, Ryo;
Nomura, Rena;
Ito, Takuya;
Konishi, Hiroki

Publication type:

Article

The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro.

Published in:

Xenobiotica, 2023, v. 53, n. 5, p. 357, doi. 10.1080/00498254.2023.2248498

By:

Kojima, Michiaki;
Machida, Kanami;
Cho, Sumie;
Watanabe, Daichi;
Seki, Hiroyuki;
Shimoji, Miyuki;
Imaoka, Ayuko;
Yamazaki, Hiroshi;
Guengerich, F. Peter;
Nakamura, Katsunori;
Yamamoto, Koujirou;
Akiyoshi, Takeshi;
Ohtani, Hisakazu

Publication type:

Article

Physiologically based pharmacokinetic modeling (PBPK) to predict drug-drug interactions for encorafenib. Part II. Prospective predictions in hepatic and renal impaired populations with clinical inhibitors and inducers.

Published in:

Xenobiotica, 2023, v. 53, n. 5, p. 339, doi. 10.1080/00498254.2023.2246153

By:

Kollipara, Sivacharan;
Ahmed, Tausif;
Praveen, Sivadasu

Publication type:

Article

Mechanism-based inactivation of cytochrome P450 3A by evodol.

Published in:

Xenobiotica, 2023, v. 53, n. 3, p. 129, doi. 10.1080/00498254.2023.2207200

By:

Zhao, Jie;
He, Jingyu;
Xu, Jie

Publication type:

Article

Curcumin and quercetin modify warfarin-induced regulation of porcine CYP1A2 and CYP3A expression and activity in vitro.

Published in:

Xenobiotica, 2022, v. 52, n. 5, p. 435, doi. 10.1080/00498254.2022.2089932

By:

Burkina, Viktoriia;
Zamaratskaia, Galia;
Rasmussen, Martin Krøyer

Publication type:

Article

In vitro assessment of the inhibitory effect of goreisan extract and its ingredients on the P-glycoprotein drug transporter and cytochrome P-450 metabolic enzymes.

Published in:

Xenobiotica, 2022, v. 52, n. 5, p. 511, doi. 10.1080/00498254.2022.2078750

By:

Takiyama, Mikina;
Matsumoto, Takashi;
Kaifuchi, Noriko;
Mizuhara, Yasuharu;
Warabi, Eiji;
Ohbuchi, Katsuya;
Mizoguchi, Kazushige

Publication type:

Article

Effect of drug combination on tacrolimus target dose in renal transplant patients with different CYP3A5 genotypes.

Published in:

Xenobiotica, 2022, v. 52, n. 3, p. 312, doi. 10.1080/00498254.2022.2064252

By:

Zhang, Shu-Fang;
Tang, Bo-Hao;
Wei, An-hua;
Du, Yue;
Guan, Zi-Wan;
Li, Yan

Publication type:

Article

Spectroscopic observations of β-eudesmol binding to human cytochrome P450 isoforms 3A4 and 1A2, but not to isoforms 2C9, 2C19, and 2D6.

Published in:

Xenobiotica, 2022, v. 52, n. 2, p. 199, doi. 10.1080/00498254.2022.2037168

By:

Krenc, Dawid;
Na-Bangchang, Kesara

Publication type:

Article

Assessment of drug-drug interactions of CC-90001, a potent and selective inhibitor of c-Jun N-terminal kinase.

Published in:

Xenobiotica, 2021, v. 51, n. 12, p. 1416, doi. 10.1080/00498254.2022.2027553

By:

Tong, Zeen;
Gaudy, Allison;
Tatosian, Daniel;
Ramirez-Valle, Francisco;
Liu, Hong;
Chen, Jian;
Hoffmann, Matthew;
Surapaneni, Sekhar

Publication type:

Article

Association between pharmacokinetics of lenvatinib in healthy subjects and genetic polymorphisms of ABCB1 3435C>T and ABCB1 2677G>T/A.

Published in:

Xenobiotica, 2021, v. 51, n. 12, p. 1463, doi. 10.1080/00498254.2021.2023913

By:

Song, Haojing;
Bai, Wanjun;
Sun, Xue;
Qiu, Bo;
Guo, Nini;
Guo, Caihui;
Hu, Yiting;
Dong, Zhanjun

Publication type:

Article

Agrimoniin inhibits the activity of CYP1A2, 2D6, and 3A4 in human liver microsomes.

Published in:

Xenobiotica, 2021, v. 51, n. 12, p. 1360, doi. 10.1080/00498254.2021.2009592

By:

Zhou, Yanqing;
Xian, Qian;
Wei, Haimin;
Zhou, Jin;
Li, Shengjian;
Yang, Junwei;
Zhou, Xuedong;
Li, Yamei

Publication type:

Article

Impact of CYP2C19 genotype on voriconazole exposure and effect of voriconazole on the activity of CYP3A in patients with haematological malignancies.

Published in:

Xenobiotica, 2021, v. 51, n. 10, p. 1199, doi. 10.1080/00498254.2021.1969481

By:

Huang, Feng-Ru;
Zhou, Chen;
Zhang, Xiao-Yan;
Shen, Ye;
Zhang, Hong-Wen;
Wang, Yong-Qing;
Sun, Lu-Ning

Publication type:

Article