Abnormal neuroinflammation in fibromyalgia and CRPS using [¹¹C]-(R)-PK11195 PET.

Seo, Seongho; Jung, Ye-Ha; Lee, Dasom; Lee, Won Joon; Jang, Joon Hwan; Lee, Jae-Yeon; Choi, Soo-Hee; Moon, Jee Youn; Lee, Jae Sung; Cheon, Gi Jeong; Kang, Do-Hyung

Purpose: Fibromyalgia (FM) and complex regional pain syndrome (CRPS) share many pathological mechanisms related to chronic pain and neuroinflammation, which may contribute to the multifactorial pathological mechanisms in both FM and CRPS. The aim of this study was to assess neuroinflammation in FM patients compared with that in patients with CRPS and healthy controls. Methods: Neuroinflammation was measured as the distribution volume ratio (DVR) of [11C]-(R)-PK11195 positron emission tomography (PET) in 12 FM patients, 11 patients with CRPS and 15 healthy controls. Results: Neuroinflammation in FM patients was significantly higher in the left pre (primary motor cortex) and post (primary somatosensory cortex) central gyri (p 11C]-(R)-PK11195 in FM patients demonstrated decreased neuroinflammation in the medulla (p 11C]-(R)-PK11195 PET. The results suggested that abnormal neuroinflammation can be an important pathological factor in FM. In addition, the identification of common and different critical regions related to abnormal neuroinflammation in FM, compared with patients with CRPS and healthy controls, may contribute to improved diagnosis and the development of effective medical treatment for patients with FM.

COMPLEX regional pain syndromes; TEMPORAL lobe; POSITRON emission tomography; INFLAMMATION; FIBROMYALGIA; AMYGDALOID body; SOMATOSENSORY cortex

PLoS ONE, 2021, Vol 16, Issue 2, p1

1932-6203

Academic Journal

10.1371/journal.pone.0246152