Works matching AU Otte, Kerstin

Results: 33

mir-124-5p Regulates Phagocytosis of Human Macrophages by Targeting the Actin Cytoskeleton via the ARP2/3 Complex.

Published in:

Frontiers in Immunology, 2019, p. 1, doi. 10.3389/fimmu.2019.02210

By:

Herdoiza Padilla, Estefania;
Crauwels, Peter;
Bergner, Tim;
Wiederspohn, Nicole;
Förstner, Sabrina;
Rinas, Rebecca;
Ruf, Anna;
Kleemann, Michael;
Handrick, René;
Tuckermann, Jan;
Otte, Kerstin;
Walther, Paul;
Riedel, Christian U.

Publication type:

Article

Three-dimensional tumor spheroids for in vitro analysis of bacteria as gene delivery vectors in tumor therapy.

Published in:

Microbial Cell Factories, 2015, v. 14, p. 1, doi. 10.1186/s12934-015-0383-5

By:

Osswald, Annika;
Sun, Zhongke;
Grimm, Verena;
Ampem, Grace;
Riegel, Karin;
Westendorf, Astrid M.;
Sommergruber, Wolfgang;
Otte, Kerstin;
Dürre, Peter;
Riedel, Christian U.

Publication type:

Article

Exploring synthetic biology for the development of a sensor cell line for automated bioprocess control.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-06272-x

By:

Zeh, Nikolas;
Bräuer, Melina;
Raab, Nadja;
Handrick, René;
Otte, Kerstin

Publication type:

Article

Establishment of Lipofection for Studying miRNA Function in Human Adipocytes.

Published in:

PLoS ONE, 2014, v. 9, n. 5, p. 1, doi. 10.1371/journal.pone.0098023

By:

Enlund, Eveliina;
Fischer, Simon;
Handrick, René;
Otte, Kerstin;
Debatin, Klaus-Michael;
Wabitsch, Martin;
Fischer-Posovszky, Pamela

Publication type:

Article

Transferability of miRNA‐technology to bioprocessing: Influence of cultivation mode and media.

Published in:

Biotechnology Progress, 2021, v. 37, n. 2, p. 1, doi. 10.1002/btpr.3107

By:

Leroux, Ann‐Cathrin;
Bartels, Elisabeth;
Winter, Luise;
Mann, Melanie;
Otte, Kerstin;
Zehe, Christoph

Publication type:

Article

Illuminating a biologics development challenge: systematic characterization of CHO cell-derived hydrolases identified in monoclonal antibody formulations.

Published in:

2024

By:

Maier, Melanie;
Weiß, Linus;
Zeh, Nikolas;
Schmieder-Todtenhaupt, Valerie;
Dehghani, Alireza;
Felix, Marius Nicolaus;
Heinzelmann, Daniel;
Lindner, Benjamin;
Schmidt, Moritz;
Studts, Joey;
Schulz, Patrick;
Reisinger, Bernd;
Otte, Kerstin;
Franzreb, Matthias;
Lakatos, Daniel;
Fischer, Simon

Publication type:

Report

Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain.

Published in:

2020

By:

Bauer, Joschka;
Mathias, Sven;
Kube, Sebastian;
Otte, Kerstin;
Garidel, Patrick;
Gamer, Martin;
Blech, Michaela;
Fischer, Simon;
Karow-Zwick, Anne R

Publication type:

Report

Identification of Farnesoid X Receptor β as a Novel Mammalian Nuclear Receptor Sensing Lanosterol.

Published in:

Molecular & Cellular Biology, 2003, v. 23, n. 3, p. 864, doi. 10.1128/MCB.23.3.864-872.2003

By:

Otte, Kerstin;
Kranz, Harald;
Kober, Ingo;
Thompson, Paul;
Hoefer, Michael;
Haubold, Bernhard;
Remmel, Bettina;
Voss, Hartmut;
Kaiser, Carmen;
Albers, Michael;
Cheruvallath, Zaccharias;
Jackson, David;
Casari, Georg;
Koegl, Manfred;
Pääbo, Svante;
Mous, Jan;
Kremoser, Claus;
Deuschle, Ulrich

Publication type:

Article

Stable overexpression of native and artificial miRNAs for the production of differentially fucosylated antibodies in CHO cells.

Published in:

Engineering in Life Sciences, 2024, v. 24, n. 6, p. 1, doi. 10.1002/elsc.202300234

By:

Schlossbauer, Patrick;
Naumann, Lukas;
Klingler, Florian;
Burkhart, Madina;
Handrick, René;
Korff, Kathrin;
Neusüß, Christian;
Otte, Kerstin;
Hesse, Friedemann

Publication type:

Article

CRISPR/Cas9‐Mediated Knockout of MicroRNA‐744 Improves Antibody Titer of CHO Production Cell Lines.

Published in:

Biotechnology Journal, 2019, v. 14, n. 5, p. N.PAG, doi. 10.1002/biot.201800477

By:

Raab, Nadja;
Mathias, Sven;
Alt, Kerstin;
Handrick, René;
Fischer, Simon;
Schmieder, Valerie;
Jadhav, Vaibhav;
Borth, Nicole;
Otte, Kerstin

Publication type:

Article

A functional high-content miRNA screen identifies miR-30 family to boost recombinant protein production in CHO cells.

Published in:

Biotechnology Journal, 2014, v. 9, n. 10, p. 1279, doi. 10.1002/biot.201400306

By:

Fischer, Simon;
Buck, Theresa;
Wagner, Andreas;
Ehrhart, Carolin;
Giancaterino, Julia;
Mang, Samuel;
Schad, Matthias;
Mathias, Sven;
Aschrafi, Armaz;
Handrick, René;
Otte, Kerstin

Publication type:

Article

Unveiling the principle of microRNA-mediated redundancy in cellular pathway regulation.

Published in:

RNA Biology, 2015, v. 12, n. 3, p. 238, doi. 10.1080/15476286.2015.1017238

By:

Fischer, Simon;
Handrick, René;
Aschrafi, Armaz;
Otte, Kerstin

Publication type:

Article

High‐throughput glycosylation analysis of intact monoclonal antibodies by mass spectrometry coupled with capillary electrophoresis and liquid chromatography.

Published in:

Journal of Separation Science, 2022, v. 45, n. 12, p. 2034, doi. 10.1002/jssc.202100865

By:

Naumann, Lukas;
Schlossbauer, Patrick;
Klingler, Florian;
Hesse, Friedemann;
Otte, Kerstin;
Neusüß, Christian

Publication type:

Article

Life at the periphery: what makes CHO cells survival talents.

Published in:

Applied Microbiology & Biotechnology, 2022, v. 106, n. 18, p. 6157, doi. 10.1007/s00253-022-12123-6

By:

Jerabek, Tobias;
Klingler, Florian;
Raab, Nadja;
Zeh, Nikolas;
Pfannstiel, Jens;
Otte, Kerstin

Publication type:

Article

Exploring the molecular content of CHO exosomes during bioprocessing.

Published in:

Applied Microbiology & Biotechnology, 2021, v. 105, n. 9, p. 3673, doi. 10.1007/s00253-021-11309-8

By:

Keysberg, Christoph;
Hertel, Oliver;
Schelletter, Louise;
Busche, Tobias;
Sochart, Chiara;
Kalinowski, Jörn;
Hoffrogge, Raimund;
Otte, Kerstin;
Noll, Thomas

Publication type:

Article

A conserved structural element in horse and mouse IGF2 genes binds a methylation sensitive factor.

Published in:

Nucleic Acids Research, 1998, v. 26, n. 7, p. 1605, doi. 10.1093/nar/26.7.1605

By:

Otte, Kerstin;
Choudhury, Devapriya;
Charalambous, Marika;
Engström, Wilhelm;
Rozell, Björn

Publication type:

Article

Human CAP cells represent a novel source for functional, miRNA-loaded exosome production.

Published in:

PLoS ONE, 2019, v. 14, n. 8, p. 1, doi. 10.1371/journal.pone.0221679

By:

Zeh, Nikolas;
Schneider, Helga;
Mathias, Sven;
Raab, Nadja;
Kleemann, Michael;
Schmidt-Hertel, Sabine;
Weis, Benjamin;
Wissing, Silke;
Strempel, Nikola;
Handrick, René;
Otte, Kerstin

Publication type:

Article

Life at the periphery.

Published in:

Pharmazeutische Industrie (Pharmind), 2021, v. 83, n. 9, p. 1241

By:

Klingler, Florian;
Mathias, Sven;
Otte, Kerstin

Publication type:

Article

Unravelling of molecular bottlenecks in pharmaceutical production cell lines.

Published in:

Pharmazeutische Industrie (Pharmind), 2020, v. 82, n. 12, p. 1604

By:

Mathias, Sven;
Otte, Kerstin

Publication type:

Article

Harnessing the Potential of MicroRNAs to Enhance Performance of Biopharmaceutical Production Cell Factories.

Published in:

Pharmazeutische Industrie (Pharmind), 2016, v. 78, n. 12, p. 1760

By:

Fischer, Simon;
Handrick, René;
Otte, Kerstin

Publication type:

Article

Fachkräfte für die Biotechnologiebranche.

Published in:

Pharmazeutische Industrie (Pharmind), 2013, v. 75, n. 11, p. 1738

By:

Otte, Kerstin

Publication type:

Article

Exploring synthetic biology for the development of a sensor cell line for automated bioprocess control.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-06272-x

By:

Zeh, Nikolas;
Bräuer, Melina;
Raab, Nadja;
Handrick, René;
Otte, Kerstin

Publication type:

Article

Developing microRNAs as engineering tools to modulate monoclonal antibody galactosylation.

Published in:

Biotechnology & Bioengineering, 2024, v. 121, n. 4, p. 1355, doi. 10.1002/bit.28616

By:

Klingler, Florian;
Schlossbauer, Patrick;
Naumann, Lukas;
Handrick, René;
Hesse, Friedemann;
Neusüß, Christian;
Otte, Kerstin

Publication type:

Article

Hyperthermic shift and cell engineering increase small extracellular vesicle production in HEK293F cells.

Published in:

Biotechnology & Bioengineering, 2024, v. 121, n. 3, p. 942, doi. 10.1002/bit.28612

By:

Keysberg, Christoph;
Hertel, Oliver;
Hoffrogge, Raimund;
Reich, Sibylle;
Hornung, Nadine;
Holzmann, Karlheinz;
Otte, Kerstin

Publication type:

Article

Production cell analysis and compound‐based boosting of small extracellular vesicle secretion using a generic and scalable production platform.

Published in:

Biotechnology & Bioengineering, 2023, v. 120, n. 4, p. 987, doi. 10.1002/bit.28322

By:

Keysberg, Christoph;
Schneider, Helga;
Otte, Kerstin

Publication type:

Article

Loss of a newly discovered microRNA in Chinese hamster ovary cells leads to upregulation of N‐glycolylneuraminic acid sialylation on monoclonal antibodies.

Published in:

Biotechnology & Bioengineering, 2022, v. 119, n. 3, p. 832, doi. 10.1002/bit.28015

By:

Fischer, Simon;
Mathias, Sven;
Stadermann, Anna;
Yang, Shumin;
Schmieder, Valerie;
Zeh, Nikolas;
Schmidt, Nicoletta;
Richter, Patrick;
Wright, Sara;
Zimmermann, Eike;
Ley, Yan;
van der Meer, Julia;
Hartsch, Thomas;
Bernloehr, Christian;
Otte, Kerstin;
Bradl, Harald;
Gamer, Martin;
Schulz, Patrick

Publication type:

Article

Unveiling the CHO surfaceome: Identification of cell surface proteins reveals cell aggregation‐relevant mechanisms.

Published in:

Biotechnology & Bioengineering, 2021, v. 118, n. 8, p. 3015, doi. 10.1002/bit.27811

By:

Klingler, Florian;
Mathias, Sven;
Schneider, Helga;
Buck, Theresa;
Raab, Nadja;
Zeh, Nikolas;
Shieh, Yu‐Wei;
Pfannstiel, Jens;
Otte, Kerstin

Publication type:

Article

Unraveling what makes a monoclonal antibody difficult‐to‐express: From intracellular accumulation to incomplete folding and degradation via ERAD.

Published in:

Biotechnology & Bioengineering, 2020, v. 117, n. 1, p. 5, doi. 10.1002/bit.27196

By:

Mathias, Sven;
Wippermann, Anna;
Raab, Nadja;
Zeh, Nikolas;
Handrick, René;
Gorr, Ingo;
Schulz, Patrick;
Fischer, Simon;
Gamer, Martin;
Otte, Kerstin

Publication type:

Article

Stable miRNA overexpression in human CAP cells: Engineering alternative production systems for advanced manufacturing of biologics using miR‐136 and miR‐3074.

Published in:

Biotechnology & Bioengineering, 2018, v. 115, n. 8, p. 2027, doi. 10.1002/bit.26715

By:

Weis, Benjamin L.;
Guth, Nadine;
Fischer, Simon;
Wissing, Silke;
Fradin, Simon;
Holzmann, Karl‐Heinz;
Handrick, René;
Otte, Kerstin

Publication type:

Article

Temperature-sensitive miR-483 is a conserved regulator of recombinant protein and viral vector production in mammalian cells.

Published in:

Biotechnology & Bioengineering, 2016, v. 113, n. 4, p. 830, doi. 10.1002/bit.25853

By:

Emmerling, Verena V.;
Fischer, Simon;
Stiefel, Fabian;
Holzmann, Karlheinz;
Handrick, René;
Hesse, Friedemann;
Hörer, Markus;
Kochanek, Stefan;
Otte, Kerstin

Publication type:

Article

miR-2861 as novel HDAC5 inhibitor in CHO cells enhances productivity while maintaining product quality.

Published in:

Biotechnology & Bioengineering, 2015, v. 112, n. 10, p. 2142, doi. 10.1002/bit.25626

By:

Fischer, Simon;
Paul, Albert Jesuran;
Wagner, Andreas;
Mathias, Sven;
Geiss, Melanie;
Schandock, Franziska;
Domnowski, Martin;
Zimmermann, Jörg;
Handrick, René;
Hesse, Friedemann;
Otte, Kerstin

Publication type:

Article

Induction of apoptosis in ovarian cancer cells by miR-493-3p directly targeting AKT2, STK38L, HMGA2, ETS1 and E2F5.

Published in:

Cellular & Molecular Life Sciences, 2019, v. 76, n. 3, p. 539, doi. 10.1007/s00018-018-2958-x

By:

Kleemann, Michael;
Schneider, Helga;
Unger, Kristian;
Bereuther, Jeremias;
Fischer, Simon;
Sander, Philip;
Marion Schneider, E.;
Fischer-Posovszky, Pamela;
Riedel, Christian U.;
Handrick, René;
Otte, Kerstin

Publication type:

Article

miR-143 targets MAPK7 in CHO cells and induces a hyperproductive phenotype to enhance production of difficult-to-express proteins.

Published in:

Biotechnology Progress, 2017, v. 33, n. 4, p. 1046, doi. 10.1002/btpr.2475

By:

Schoellhorn, Melanie;
Fischer, Simon;
Wagner, Andreas;
Handrick, René;
Otte, Kerstin

Publication type:

Article