Works matching Drug metabolism

Results: 5000

Age-related modifications in CYP-dependent drug metabolism: role of stress.

Published in:

Frontiers in Endocrinology, 2023, p. 1, doi. 10.3389/fendo.2023.1143835

By:

Konstandi, Maria;
Johnson, Elizabeth O.

Publication type:

Article

Drug metabolism and transport mediated the hepatotoxicity of Pleuropterus multiflorus root: a review.

Published in:

Drug Metabolism Reviews, 2024, v. 56, n. 4, p. 349, doi. 10.1080/03602532.2024.2405163

By:

Wu, Zhaoquan;
Shangguan, Dangang;
Huang, Qi;
Wang, Yi-Kun

Publication type:

Article

Cytochrome P450-mediated carbon-carbon bond formation in drug metabolism.

Published in:

2025

By:

Liu, Joyce;
Zhang, Donglu

Publication type:

Literature Review

The alteration of drug metabolism enzymes and pharmacokinetic parameters in nonalcoholic fatty liver disease: current animal models and clinical practice.

Published in:

Drug Metabolism Reviews, 2023, v. 55, n. 3, p. 163, doi. 10.1080/03602532.2023.2202359

By:

Zhu, Yan;
Chen, Li;
He, Yuqi;
Qin, Lin;
Tan, Daopeng;
Bai, Zhaojun;
Song, Yu;
Wang, Yu-He

Publication type:

Article

A transcriptional regulatory network of HNF4α and HNF1α involved in human diseases and drug metabolism.

Published in:

Drug Metabolism Reviews, 2022, v. 54, n. 4, p. 361, doi. 10.1080/03602532.2022.2103146

By:

Yang, Jianxin;
Bai, Xue;
Liu, Guiqin;
Li, Xiangyang

Publication type:

Article

Aldehyde oxidase mediated drug metabolism: an underpredicted obstacle in drug discovery and development.

Published in:

Drug Metabolism Reviews, 2022, v. 54, n. 4, p. 427, doi. 10.1080/03602532.2022.2144879

By:

Gajula, Siva Nageswara Rao;
Nathani, Tanaaz Navin;
Patil, Rashmi Madhukar;
Talari, Sasikala;
Sonti, Rajesh

Publication type:

Article

Advances in the study of drug metabolism – symposium report of the 12th Meeting of the International Society for the Study of Xenobiotics (ISSX).

Published in:

Drug Metabolism Reviews, 2020, v. 52, n. 3, p. 395, doi. 10.1080/03602532.2020.1765793

By:

Russell, Laura E.;
Schleiff, Mary Alexandra;
Gonzalez, Eric;
Bart, Aaron G.;
Broccatelli, Fabio;
Hartman, Jessica H.;
Humphreys, W. Griffith;
Lauschke, Volker M.;
Martin, Iain;
Nwabufo, Chukwunonso;
Prasad, Bhagwat;
Scott, Emily E.;
Segall, Matthew;
Takahashi, Ryan;
Taub, Mitchell E.;
Sodhi, Jasleen K.

Publication type:

Article

Profiles in drug metabolism and toxicology: Richard Tecwyn Williams (1909–1979).

Published in:

Drug Metabolism Reviews, 2015, v. 47, n. 4, p. 401, doi. 10.3109/03602532.2015.1115516

By:

Jones, Alan Wayne

Publication type:

Article

Applications of mass spectrometry in drug metabolism: 50 years of progress*.

Published in:

Drug Metabolism Reviews, 2015, v. 47, n. 1, p. 71, doi. 10.3109/03602532.2014.1001029

By:

Wen, Bo;
Zhu, Mingshe

Publication type:

Article

Carbonyl reduction pathways in drug metabolism.

Published in:

Drug Metabolism Reviews, 2014, v. 46, n. 1, p. 96, doi. 10.3109/03602532.2013.853078

By:

Malátková, Petra;
Wsól, Vladimír

Publication type:

Article

Drug metabolism and drug transport of the 100 most prescribed oral drugs.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2022, v. 131, n. 5, p. 311, doi. 10.1111/bcpt.13780

By:

Iversen, Ditte B.;
Andersen, Nanna Elman;
Dalgård Dunvald, Ann‐Cathrine;
Pottegård, Anton;
Stage, Tore B.

Publication type:

Article

The Combination of Electrochemistry and Microfluidic Technology in Drug Metabolism Studies.

Published in:

ChemistryOpen, 2022, v. 11, n. 12, p. 1, doi. 10.1002/open.202200100

By:

Grint, Isobel;
Crea, Francesco;
Vasiliadou, Rafaela

Publication type:

Article

Pharmacometabolomics Enables Real-World Drug Metabolism Sciences.

Published in:

Metabolites (2218-1989), 2025, v. 15, n. 1, p. 39, doi. 10.3390/metabo15010039

By:

Nijdam, Fleur B.;
Hof, Marieke A. J.;
Blokzijl, Hans;
Bakker, Stephan J. L.;
Hak, Eelko;
Hopfgartner, Gérard;
Klont, Frank

Publication type:

Article

Sulfotransferase‐mediated phase II drug metabolism prediction of substrates and sites using accessibility and reactivity‐based algorithms.

Published in:

Molecular Informatics, 2024, v. 43, n. 10, p. 1, doi. 10.1002/minf.202400008

By:

Vyas, Shivam Kumar;
Das, Avik;
Suryanarayana Murty, Upadhyayula;
Dixit, Vaibhav A.

Publication type:

Article

The Complex Dynamic of Phase I Drug Metabolism in the Early Stages of Doxorubicin Resistance in Breast Cancer Cells.

Published in:

Genes, 2022, v. 13, n. 11, p. 1977, doi. 10.3390/genes13111977

By:

Barata, Isabel S.;
Gomes, Bruno C.;
Rodrigues, António S.;
Rueff, José;
Kranendonk, Michel;
Esteves, Francisco

Publication type:

Article

Distinct Effects of Inflammation on Cytochrome P450 Regulation and Drug Metabolism: Lessons from Experimental Models and a Potential Role for Pharmacogenetics.

Published in:

Genes, 2020, v. 11, n. 12, p. 1509, doi. 10.3390/genes11121509

By:

de Jong, Laura M.;
Jiskoot, Wim;
Swen, Jesse J.;
Manson, Martijn L.

Publication type:

Article

Utility of Common Marmoset (Callithrix jacchus) Embryonic Stem Cells in Liver Disease Modeling, Tissue Engineering and Drug Metabolism.

Published in:

Genes, 2020, v. 11, n. 7, p. 729, doi. 10.3390/genes11070729

By:

Aravalli, Rajagopal N.;
Steer, Clifford J.

Publication type:

Article

Insights into molecular mechanisms of drug metabolism dysfunction of human CYP2C9*30.

Published in:

PLoS ONE, 2018, v. 13, n. 5, p. 1, doi. 10.1371/journal.pone.0197249

By:

Louet, Maxime;
Labbé, Céline M.;
Fagnen, Charline;
Aono, Cassiano M.;
Homem-de-Mello, Paula;
Villoutreix, Bruno O.;
Miteva, Maria A.

Publication type:

Article

Engineering HepG2 spheroids with injectable fiber fragments as predictable models for drug metabolism and tumor infiltration.

Published in:

Journal of Biomedical Materials Research, Part B: Applied Biomaterials, 2020, v. 108, n. 8, p. 3331, doi. 10.1002/jbm.b.34669

By:

Wei, Jiaojun;
Lei, Dongmei;
Chen, Maohua;
Ran, Pan;
Li, Xiaohong

Publication type:

Article

Drug metabolism.

Published in:

Resonance: Journal of Science Education, 2014, v. 19, n. 3, p. 259, doi. 10.1007/s12045-014-0031-0

By:

Taxak, Nikhil;
Bharatam, Prasad

Publication type:

Article

Isoform-Dependent Changes in Cytochrome P450-Mediated Drug Metabolism after Portal Vein Ligation in the Rat.

Published in:

European Surgical Research, 2018, v. 59, n. 5/6, p. 301, doi. 10.1159/000493923

By:

Kovács, Tibor;
Déri, Máté;
Fülöp, András;
Pálházy, Tímea;
Háfra, Edit;
Sirok, Dávid;
Kiss, Ádám Ferenc;
Lotz, Gábor;
Szijártó, Attila;
Monostory, Katalin

Publication type:

Article

DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver.

Published in:

GeroScience, 2020, v. 42, n. 3, p. 819, doi. 10.1007/s11357-020-00181-5

By:

Kronfol, Mohamad M.;
Jahr, Fay M.;
Dozmorov, Mikhail G.;
Phansalkar, Palak S.;
Xie, Lin Y.;
Aberg, Karolina A.;
McRae, MaryPeace;
Price, Elvin T.;
Slattum, Patricia W.;
Gerk, Philip M.;
McClay, Joseph L.

Publication type:

Article

Structure-based Drug Metabolism Predictions for Drug Design.

Published in:

Chemical Biology & Drug Design, 2010, v. 75, n. 1, p. 3, doi. 10.1111/j.1747-0285.2009.00899.x

By:

Hao Sun;
Scott, Dennis O.

Publication type:

Article

Changes in the intestinal expression of drug metabolism-related genes in a piglet model of parenteral nutrition.

Published in:

Nutrition & Metabolism, 2022, v. 19, n. 1, p. 1, doi. 10.1186/s12986-022-00654-8

By:

Dai, Li-Na;
Zhao, Yu-Ling;
Jiang, Lu;
Yan, Jun-Kai

Publication type:

Article

High fat diet significantly changed the global gene expression profile involved in hepatic drug metabolism and pharmacokinetic system in mice.

Published in:

Nutrition & Metabolism, 2020, v. 17, n. 1, p. 1, doi. 10.1186/s12986-020-00456-w

By:

He, Yuqi;
Yang, Tao;
Du, Yimei;
Qin, Lin;
Ma, Feifei;
Wu, Zunping;
Ling, Hua;
Yang, Li;
Wang, Zhengtao;
Zhou, Qingdi;
Ge, Guangbo;
Lu, Yanliu

Publication type:

Article

Different drug metabolism behavior between species in drug-induced hepatotoxicity: limitations and novel resolutions.

Published in:

2021

By:

Han, Weijia;
Duan, Zhongping

Publication type:

Literature Review

Impact of individual factors on DNA methylation of drug metabolism genes: A systematic review.

Published in:

Environmental & Molecular Mutagenesis, 2023, v. 64, n. 7, p. 401, doi. 10.1002/em.22567

By:

Bian, Jialu;
Zhao, Jinxia;
Zhao, Yinyu;
Hao, Xu;
He, Shiyu;
Li, Yuanyuan;
Huang, Lin

Publication type:

Article

Drug metabolism and pharmacogenetics: the British contribution to fields of international significance.

Published in:

2006

By:

Caldwell, John

Publication type:

journal article

Transcriptomic profiling of hepatic tissues for drug metabolism genes in nonalcoholic fatty liver disease: A study of human and animals.

Published in:

Frontiers in Endocrinology, 2023, v. 13, p. 1, doi. 10.3389/fendo.2022.1034494

By:

Li Chen;
Lu Chen;
Xu Li;
Lin Qin;
Yan Zhu;
Qianru Zhang;
Daopeng Tan;
Yuqi He;
Yu-He Wang

Publication type:

Article

Recellularization of rat liver: An in vitro model for assessing human drug metabolism and liver biology.

Published in:

PLoS ONE, 2018, v. 13, n. 1, p. 1, doi. 10.1371/journal.pone.0191892

By:

Robertson, Matthew J.;
Soibam, Benjamin;
O’Leary, Jacqueline G.;
Sampaio, Luiz C.;
Taylor, Doris A.

Publication type:

Article

Effects of meal composition and meal timing on the expression of genes involved in hepatic drug metabolism in rats.

Published in:

PLoS ONE, 2017, v. 12, n. 10, p. 1, doi. 10.1371/journal.pone.0185520

By:

de Vries, E. M.;
Romijn, J. A.;
Oosterman, J. E.;
Eggink, H. M.;
de Goede, P.;
Boudzovitch-Surovtseva, O.;
Boelen, A.;
Kalsbeek, A.;
laFleur, S. E.;
Sen, S.;
Foppen, E.

Publication type:

Article

The gene expression profile of a drug metabolism system and signal transduction pathways in the liver of mice treated with tert-butylhydroquinone or 3-(3'-tert-butyl-4'-hydroxyphenyl)propylthiosulfonate of sodium.

Published in:

PLoS ONE, 2017, v. 12, n. 5, p. 1, doi. 10.1371/journal.pone.0176939

By:

Shintyapina, Alexandra B.;
Vavilin, Valentin A.;
Safronova, Olga G.;
Lyakhovich, Vyacheslav V.

Publication type:

Article

CYP3A4 and CYP3A5: the crucial roles in clinical drug metabolism and the significant implications of genetic polymorphisms.

Published in:

PeerJ, 2024, p. 1, doi. 10.7717/peerj.18636

By:

Zhang, Yuqing;
Wang, Ziying;
Wang, Yuchao;
Jin, Weikai;
Zhang, Zheyan;
Jin, Lehao;
Qian, Jianchang;
Zheng, Long

Publication type:

Article

CYP3A-Mediated Carbon–Carbon Bond Cleavages in Drug Metabolism.

Published in:

Biomolecules (2218-273X), 2024, v. 14, n. 9, p. 1125, doi. 10.3390/biom14091125

By:

Zhou, Junhui;
Qin, Xuan;
Zhou, Shenzhi;
MacKenzie, Kevin R.;
Li, Feng

Publication type:

Article

Human induced pluripotent stem cell-derived liver-on-a-chip for studying drug metabolism: the challenge of the cytochrome P450 family.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1223108

By:

Tamargo-Rubio, Isabel;
Simpson, Anna Bella;
Hoogerland, Joanne A.;
Jingyuan Fu

Publication type:

Article

Inflammatory signaling on cytochrome P450-mediated drug metabolism in hepatocytes.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.1043836

By:

Xiaokang Wang;
Jiaoyu Rao;
Zhiyi Tan;
Tianrong Xun;
Jingqian Zhao;
Xixiao Yang

Publication type:

Article

Butyrate Treatment of DSS-Induced Ulcerative Colitis Affects the Hepatic Drug Metabolism in Mice.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.936013

By:

Jourova, Lenka;
Satka, Stefan;
Frybortova, Veronika;
Zapletalova, Iveta;
Anzenbacher, Pavel;
Anzenbacherova, Eva;
Hermanova, Petra Petr;
Drabonova, Barbora;
Srutkova, Dagmar;
Kozakova, Hana;
Hudcovic, Tomas

Publication type:

Article

Polymorphism in CYP2D6 and CYP2C19, members of the cytochrome P450 mixed-function oxidase system, in the metabolism of psychotropic drugs.

Published in:

Journal of Internal Medicine, 2015, v. 277, n. 2, p. 167, doi. 10.1111/joim.12317

By:

Stingl, J.;
Viviani, R.

Publication type:

Article

Induction of Liver Size Reduction in Zebrafish Larvae by the Emerging Synthetic Cannabinoid 4F-MDMB-BINACA and Its Impact on Drug Metabolism.

Published in:

Molecules, 2022, v. 27, n. 4, p. 1290, doi. 10.3390/molecules27041290

By:

Park, Yu Mi;
Dahlem, Charlotte;
Meyer, Markus R.;
Kiemer, Alexandra K.;
Müller, Rolf;
Herrmann, Jennifer

Publication type:

Article

Drug Administration Routes Impact the Metabolism of a Synthetic Cannabinoid in the Zebrafish Larvae Model.

Published in:

Molecules, 2020, v. 25, n. 19, p. 4474, doi. 10.3390/molecules25194474

By:

Park, Yu Mi;
Meyer, Markus R.;
Müller, Rolf;
Herrmann, Jennifer;
Shimada, Yasuhito;
Spaink, Herman P.

Publication type:

Article

Drug metabolism in severe chronic obstructive pulmonary disease: A phenotyping cocktail study.

Published in:

British Journal of Clinical Pharmacology, 2021, v. 87, n. 11, p. 4397, doi. 10.1111/bcp.14862

By:

McNeill, Richard P.;
Zhang, Mei;
Epton, Michael J.;
Doogue, Matthew P.

Publication type:

Article

Microfluidic models in liver drug metabolism research.

Published in:

Journal of Chinese Pharmaceutical Sciences, 2019, v. 28, n. 7, p. 449

By:

Lin Zhao;
Yong Jiang;
Pengfei Tu;
Xiaoni Ai;
Xiaoyu Guo

Publication type:

Article

Polymorphisms in drug metabolism genes as a risk factor for first-line anti-tuberculosis drug-induced liver injury.

Published in:

Molecular Biology Reports, 2023, v. 50, n. 3, p. 2893, doi. 10.1007/s11033-022-08158-7

By:

Meitei, Heikrujam Nilkanta;
Pandey, Anupama;
Haobam, Reena

Publication type:

Article

Considerations and recent advances in QSAR models for cytochrome P450-mediated drug metabolism prediction.

Published in:

Journal of Computer-Aided Molecular Design, 2008, v. 22, n. 11, p. 843, doi. 10.1007/s10822-008-9225-4

By:

Li, Haiyan;
Sun, Jin;
Fan, Xiaowen;
Sui, Xiaofan;
Zhang, Lan;
Wang, Yongjun;
He, Zhonggui

Publication type:

Article

The Gut Microbiota's Role in Drug Absorption, Metabolism and Efficacy: Implications for Personalized Medicine.

Published in:

Yemeni Journal for Medical Sciences, 2025, v. 19, n. 3, p. 1, doi. 10.20428/yjms.v19i3.2745

By:

Ahmed Saeed, Mohammed Ali;
Abdulghani, Mahfoudh A. M.;
Muthanna, Fares M. S.;
Naji, Taha A. A.;
Shaher, Fahmi;
Alshameeri, Mohammed Muammar;
Al-Wesabi, Mohammed Ali;
Alhafedhi, Mahmoud A.;
Bin-Hameed, Eidha Ali

Publication type:

Article

Innovative approaches and recent advances in the study of ontogeny of drug metabolism and transport.

Published in:

British Journal of Clinical Pharmacology, 2022, v. 88, n. 10, p. 4285, doi. 10.1111/bcp.14534

By:

van Groen, Bianca D.;
Allegaert, Karel;
Tibboel, Dick;
de Wildt, Saskia N.

Publication type:

Article

Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole.

Published in:

Oncogene, 2007, v. 26, n. 2, p. 258, doi. 10.1038/sj.onc.1209788

By:

Huang, H.;
Wang, H.;
Sinz, M.;
Zoeckler, M.;
Staudinger, J.;
Redinbo, M. R.;
Teotico, D. G.;
Locker, J.;
Kalpana, G. V.;
Mani, S.

Publication type:

Article

Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease.

Published in:

PLoS ONE, 2016, v. 11, n. 3, p. 1, doi. 10.1371/journal.pone.0152007

By:

Nicoli, Elena-Raluca;
Al Eisa, Nada;
Cluzeau, Celine V. M.;
Wassif, Christopher A.;
Gray, James;
Burkert, Kathryn R.;
Smith, David A.;
Morris, Lauren;
Cologna, Stephanie M.;
Peer, Cody J.;
Sissung, Tristan M.;
Uscatu, Constantin-Daniel;
Figg, William D.;
Pavan, William J.;
Vite, Charles H.;
Porter, Forbes D.;
Platt, Frances M.

Publication type:

Article

Analysis for drug metabolism-related prognostic subtypes and gene signature in liver cancer.

Published in:

Genes & Genetic Systems, 2022, v. 97, n. 6, p. 271, doi. 10.1266/ggs.22-00093

By:

Yue Zhang;
Jun Chen;
Chengru Hu;
Xiangzhong Huang;
Yan Li

Publication type:

Article

Ontogeny and drug metabolism in newborns.

Published in:

Journal of Maternal-Fetal & Neonatal Medicine, 2012, v. 25, p. 75, doi. 10.3109/14767058.2012.715463

By:

Dotta, Andrea;
Chukhlantseva, Natalia

Publication type:

Article