Results
Title

Combination of Zinc and All-Trans Retinoic Acid Promotes Protection against Listeria monocytogenes Infection.

Authors

Castillo, Yussaira; Tachibana, Masato; Nakatsu, Yukiko; Watanabe, Kenta; Shimizu, Takashi; Watarai, Masahisa

Abstract

Zinc (Zn) is the second most abundant transition metal after iron. It plays a vital role in living organisms and affects multiple aspects of the immune system. All-trans retinoic acid (atRA) is an isomeric form of the vitamin A or retinol. It possesses the greatest biological activity of Vitamin A. Vitamin A and related retinoids influence many aspects of immunity. In this study, we demonstrated that treatment with a combination of Zn and atRA contributes to host resistance against infection by Listeria monocytogenes. Pretreatment with Zn and atRA enhanced resistance against L. monocytogenes infection in mice and treatment with both Zn and atRA showed a higher protective effect than treatment with either alone. Supplementation with Zn, atRA or their combination decreased the number of L. monocytogenes present in target organs. In vitro, supplementation increased the bacterial uptake by macrophage cells and reduced the replication of L. monocytogenes. Our results suggest that the combination of Zn and atRA has a great bacteriostatic impact on L. monocytogenes and its infection.

Subjects

TRETINOIN; LISTERIA monocytogenes; LISTERIOSIS; IMMUNE system; VITAMIN A; RETINOIDS; DIAGNOSIS

Publication

PLoS ONE, 2015, Vol 10, Issue 9, p1

ISSN

1932-6203

Publication type

Academic Journal

DOI

10.1371/journal.pone.0137463