Results: 88
Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers.
- Published in:
- Biochemical Journal, 2016, v. 473, n. 12, p. 1719, doi. 10.1042/BCJ20160031
- By:
- Publication type:
- Article
Up-regulation of Ras/Raf/ERK1/2 signaling impairs cultured neuronal cell migration, neurogenesis, synapse formation, and dendritic spine development.
- Published in:
- Brain Structure & Function, 2013, v. 218, n. 3, p. 669, doi. 10.1007/s00429-012-0420-7
- By:
- Publication type:
- Article
The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies.
- Published in:
- Nature Genetics, 2015, v. 47, n. 3, p. 250, doi. 10.1038/ng.3218
- By:
- Publication type:
- Article
Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells.
- Published in:
- 2018
- By:
- Publication type:
- journal article
The important roles of RET, VEGFR2 and the RAF/MEK/ERK pathway in cancer treatment with sorafenib.
- Published in:
- Acta Pharmacologica Sinica, 2012, v. 33, n. 10, p. 1311, doi. 10.1038/aps.2012.76
- By:
- Publication type:
- Article
Pentoxifylline inhibits hepatic stellate cells proliferation via the Raf/ ERK pathway.
- Published in:
- APMIS, 2012, v. 120, n. 7, p. 572, doi. 10.1111/j.1600-0463.2011.02868.x
- By:
- Publication type:
- Article
The Ras/ MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications.
- Published in:
- European Journal of Clinical Investigation, 2015, v. 45, n. 6, p. 609, doi. 10.1111/eci.12441
- By:
- Publication type:
- Article
Anti-apoptotic BCL-2 proteins govern cellular outcome following B-RAF<sup>V600E</sup> inhibition and can be targeted to reduce resistance.
- Published in:
- Oncogene, 2015, v. 34, n. 7, p. 857, doi. 10.1038/onc.2014.21
- By:
- Publication type:
- Article
Human skin neural crest progenitor cells are susceptible to BRAF<sup>V600E</sup>-induced transformation.
- Published in:
- Oncogene, 2014, v. 33, n. 7, p. 832, doi. 10.1038/onc.2012.642
- By:
- Publication type:
- Article
The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα<sup>+</sup> breast cancer cells.
- Published in:
- Oncogene, 2014, v. 33, n. 5, p. 599, doi. 10.1038/onc.2012.628
- By:
- Publication type:
- Article
Targeted therapy for melanoma: rational combinatorial approaches.
- Published in:
- Oncogene, 2014, v. 33, n. 1, p. 1, doi. 10.1038/onc.2013.34
- By:
- Publication type:
- Article
Essential, non-redundant roles of B-Raf and Raf-1 in Ras-driven skin tumorigenesis.
- Published in:
- Oncogene, 2013, v. 32, n. 19, p. 2483, doi. 10.1038/onc.2012.254
- By:
- Publication type:
- Article
Mechanisms of acquired resistance to ERK1/2 pathway inhibitors.
- Published in:
- Oncogene, 2013, v. 32, n. 10, p. 1207, doi. 10.1038/onc.2012.160
- By:
- Publication type:
- Article
Phosphorylation of Mps1 by BRAF<sup>V600E</sup> prevents Mps1 degradation and contributes to chromosome instability in melanoma.
- Published in:
- Oncogene, 2013, v. 32, n. 6, p. 713, doi. 10.1038/onc.2012.94
- By:
- Publication type:
- Article
Raf activation by Ras and promotion of cellular metastasis require phosphorylation of prohibitin in the raft domain of the plasma membrane.
- Published in:
- Oncogene, 2013, v. 32, n. 6, p. 777, doi. 10.1038/onc.2012.86
- By:
- Publication type:
- Article
Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growth.
- Published in:
- Oncogene, 2012, v. 31, n. 46, p. 4848, doi. 10.1038/onc.2011.644
- By:
- Publication type:
- Article
An association between the reduced levels of SLC1A2 and GAD1 in the dorsolateral prefrontal cortex in major depressive disorder: possible involvement of an attenuated RAF/MEK/ERK signaling pathway.
- Published in:
- Journal of Neural Transmission, 2014, v. 121, n. 7, p. 783, doi. 10.1007/s00702-014-1189-z
- By:
- Publication type:
- Article
RKIP and 14-3-3ε Exert an Opposite Effect on Human Gastric Cancer Cells SGC7901 by Regulating the ERK/MAPK Pathway Differently.
- Published in:
- Digestive Diseases & Sciences, 2013, v. 58, n. 2, p. 389, doi. 10.1007/s10620-012-2341-y
- By:
- Publication type:
- Article
Integrated RAS signaling defined by parallel NMR detection of effectors and regulators.
- Published in:
- Nature Chemical Biology, 2014, v. 10, n. 3, p. 223, doi. 10.1038/nchembio.1435
- By:
- Publication type:
- Article
Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.
- Published in:
- Nature Chemical Biology, 2013, v. 9, n. 7, p. 428, doi. 10.1038/nchembio.1257
- By:
- Publication type:
- Article
Drug resistance: The stroma's contribution.
- Published in:
- Nature Chemical Biology, 2012, v. 8, n. 9, p. 739, doi. 10.1038/nchembio.1055
- By:
- Publication type:
- Article
Case series: indoor-photosensitivity caused by fluorescent lamps in patients treated with vemurafenib for metastatic melanoma.
- Published in:
- BMC Cancer, 2014, v. 14, n. 1, p. 1, doi. 10.1186/1471-2407-14-967
- By:
- Publication type:
- Article
TRPC1/3/6 inhibition attenuates the TGF‐β1‐induced epithelial–mesenchymal transition in gastric cancer via the Ras/Raf1/ERK signaling pathway.
- Published in:
- Cell Biology International, 2018, v. 42, n. 8, p. 975, doi. 10.1002/cbin.10963
- By:
- Publication type:
- Article
Tumor adaptation and resistance to RAF inhibitors.
- Published in:
- Nature Medicine, 2013, v. 19, n. 11, p. 1401, doi. 10.1038/nm.3392
- By:
- Publication type:
- Article
Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events, but with different kinetics and intensity in Caco-2 cells.
- Published in:
- Lipids in Health & Disease, 2013, v. 12, n. 1, p. 1, doi. 10.1186/1476-511X-12-101
- By:
- Publication type:
- Article
TRAF3IP2 gene and systemic lupus erythematosus: association with disease susceptibility and pericarditis development.
- Published in:
- Immunogenetics, 2013, v. 65, n. 10, p. 703, doi. 10.1007/s00251-013-0717-6
- By:
- Publication type:
- Article
Hepatitis B virus regulation of Raf1 promoter activity through activation of transcription factor AP-2α.
- Published in:
- 2013
- By:
- Publication type:
- Report
An amino-terminal BRAF deletion accounting for acquired resistance to RAF/EGFR inhibition in colorectal cancer.
- Published in:
- Cold Spring Harbor Molecular Case Studies, 2020, v. 6, n. 4, p. 1, doi. 10.1101/mcs.a005140
- By:
- Publication type:
- Article
Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond.
- Published in:
- Nature Reviews Cancer, 2014, v. 14, n. 7, p. 455, doi. 10.1038/nrc3760
- By:
- Publication type:
- Article
Therapeutics: iterations of BRAF.
- Published in:
- 2012
- By:
- Publication type:
- journal article
Raf kinase inhibitor protein: lessons of a better way for β-adrenergic receptor activation in the heart.
- Published in:
- Journal of Physiology, 2017, v. 595, n. 12, p. 4073, doi. 10.1113/JP274064
- By:
- Publication type:
- Article
CInQ-03, a novel allosteric MEK inhibitor, suppresses cancer growth in vitro and in vivo.
- Published in:
- Carcinogenesis, 2013, v. 34, n. 5, p. 1134, doi. 10.1093/carcin/bgt015
- By:
- Publication type:
- Article
The BH3-mimetic ABT-737 sensitizes human melanoma cells to apoptosis induced by selective BRAF inhibitors but does not reverse acquired resistance.
- Published in:
- Carcinogenesis, 2013, v. 34, n. 2, p. 237, doi. 10.1093/carcin/bgs330
- By:
- Publication type:
- Article
Bioinformatics Approach for Prediction of Functional Coding/Noncoding Simple Polymorphisms (SNPs/Indels) in Human BRAF Gene.
- Published in:
- Advances in Bioinformatics, 2016, p. 1, doi. 10.1155/2016/2632917
- By:
- Publication type:
- Article
Combination of a Selective HSP90α/β Inhibitor and a RAS-RAF-MEK-ERK Signaling Pathway Inhibitor Triggers Synergistic Cytotoxicity in Multiple Myeloma Cells.
- Published in:
- PLoS ONE, 2015, v. 10, n. 12, p. 1, doi. 10.1371/journal.pone.0143847
- By:
- Publication type:
- Article
Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma.
- Published in:
- PLoS ONE, 2015, v. 10, n. 9, p. 1, doi. 10.1371/journal.pone.0138210
- By:
- Publication type:
- Article
Astragaloside IV Attenuates Glutamate-Induced Neurotoxicity in PC12 Cells through Raf-MEK-ERK Pathway.
- Published in:
- PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0126603
- By:
- Publication type:
- Article
Trametinib with or without Vemurafenib in BRAF Mutated Non-Small Cell Lung Cancer.
- Published in:
- PLoS ONE, 2015, v. 10, n. 2, p. 1, doi. 10.1371/journal.pone.0118210
- By:
- Publication type:
- Article
BRAF<sup>V600E</sup> Mutation and Its Association with Clinicopathological Features of Colorectal Cancer: A Systematic Review and Meta-Analysis.
- Published in:
- PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0090607
- By:
- Publication type:
- Article
An RNAi-Based Dimorphic Genetic Screen Identified the Double Bromodomain Protein BET-1 as a Sumo-Dependent Attenuator of RAS-Mediated Signalling.
- Published in:
- PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0083659
- By:
- Publication type:
- Article
Regulation of mTORC1 Signaling by pH.
- Published in:
- PLoS ONE, 2011, v. 6, n. 6, p. 1, doi. 10.1371/journal.pone.0021549
- By:
- Publication type:
- Article
a1A-Adrenergic Receptor Induces Activation of Extracellular Signal-Regulated Kinase 1/2 through Endocytic Pathway.
- Published in:
- PLoS ONE, 2011, v. 6, n. 6, p. 1, doi. 10.1371/journal.pone.0021520
- By:
- Publication type:
- Article
Stimulation of β-adrenergic receptors plays a protective role via increased expression of RAF-1 and PDX-1 in hyperglycemic rat pancreatic islet (RIN-m5F) cells.
- Published in:
- 2017
- By:
- Publication type:
- journal article
Apoptosis in glioma-bearing rats after neural stem cell transplantation.
- Published in:
- Neural Regeneration Research, 2013, v. 8, n. 19, p. 1793, doi. 10.3969/j.issn.1673-5374.2013.19.007
- By:
- Publication type:
- Article
Anti-inflammatory effects of dabrafenib in vitro and in vivo.
- Published in:
- Canadian Journal of Physiology & Pharmacology, 2017, v. 95, n. 6, p. 697, doi. 10.1139/cjpp-2016-0519
- By:
- Publication type:
- Article
C- Raf deficiency leads to hearing loss and increased noise susceptibility.
- Published in:
- Cellular & Molecular Life Sciences, 2015, v. 72, n. 20, p. 3983, doi. 10.1007/s00018-015-1919-x
- By:
- Publication type:
- Article
Abiotic stress-induced accumulation of raffinose in Arabidopsis leaves is mediated by a single raffinose synthase (RS5, At5g40390).
- Published in:
- BMC Plant Biology, 2013, v. 13, n. 1, p. 1, doi. 10.1186/1471-2229-13-218
- By:
- Publication type:
- Article
Mécanismes de résistances aux inhibiteurs de RAF : revue de la littérature.
- Published in:
- Oncologie (Tech Science Press), 2012, v. 14, n. 1, p. 2, doi. 10.1007/s10269-011-2100-2
- By:
- Publication type:
- Article
BRAF V600E-Negative Hairy Cell Leukaemia.
- Published in:
- Case Reports in Hematology, 2013, p. 1, doi. 10.1155/2013/513049
- By:
- Publication type:
- Article
Raf kinases in signal transduction and interaction with translation machinery.
- Published in:
- Biomolecular Concepts, 2013, v. 4, n. 4, p. 391, doi. 10.1515/bmc-2013-0003
- By:
- Publication type:
- Article