Works matching DE "DRUG development"

Results: 5000

Harnessing dual variational autoencoders to decode microbe roles in diseases for traditional medicine discovery.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1578140

By:

Ye, Qing;
Sun, Yaxin

Publication type:

Article

Contribution of multimodal ultrasound in evaluating the efficacy of lumbricus protein fast dissolving tablets against atherosclerotic plaques in ApoE<sup>(−/−)</sup> mice.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1551833

By:

Lu, Zhihao;
Wang, Ning;
Yu, Quanlin;
Feng, Jing;
Dong, Jianteng;
Zhao, Xu;
Cai, Chengke;
Li, Jian;
Zhong, Liqun

Publication type:

Article

Analyzing collaboration dynamics in new drug R&D: A case study of two lipid-lowering drugs.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1516882

By:

Zhang, Nan;
Guo, Huaqing;
Zhang, Mengchao;
Wang, Chen;
Tian, Ruonan;
Shi, Yan;
Duan, Zhiguang

Publication type:

Article

Advances on cancer vaccine trials registered in China and the USA in 2014-2024.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1557253

By:

Shi, Wei;
Chen, Zhuo;
Yu, Qin;
Zhang, Lingli

Publication type:

Article

Investigation of GPR137C as a promising novel marker for the progression of prostate cancer through G4 screen and bioinformatics analyses.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1576835

By:

Hou, Yue;
Lu, Haowen;
Chen, Saisai;
Mao, Likai;
Huang, Xuan;
Xu, Feng;
Shu, Chuanjun

Publication type:

Article

Research progress of B7-H3 in malignant tumors.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1586759

By:

Zhao, Shuaixiang;
Zhang, He;
Shang, Guanning

Publication type:

Article

Development and Validation of a Robust LC-MS/MS Method for Quantitation of a Novel Kinase Inhibitor, Ritlecitinib, in Rat Plasma: Application in Pharmacokinetic Study.

Published in:

Journal of Pharmacology & Pharmacotherapeutics, 2025, v. 16, n. 3, p. 302, doi. 10.1177/0976500X241289642

By:

Kumar, Katari Pavan;
Rao, Areti Anka

Publication type:

Article

Recent progress in the development of localized drug delivery systems for oral mucosal disorders using mucoadhesive patches.

Published in:

Journal of Research in Pharmacy, 2025, v. 29, n. 3, p. 1350, doi. 10.12991/jrespharm.1712426

By:

TÜKÜÇ, Tuna Barkin;
ALARÇIN, Emine;
ÖZTÜRK, Ayça BAL

Publication type:

Article

Applying Machine Learning Techniques to Predict Drug-Related Side Effect: A Policy Brief.

Published in:

Inquiry (00469580), 2025, v. 62, p. 1, doi. 10.1177/00469580251335805

By:

Toni, Esmaeel;
Ayatollahi, Haleh

Publication type:

Article

Evaluation of the α-amylase, α-glucosidase, and tyrosinase inhibitory and photoprotective activities of organic solvent and aqueous Extracts of Retama monosperma stem.

Published in:

Tropical Journal of Natural Product Research, 2025, v. 9, n. 5, p. 2357, doi. 10.26538/tjnpr/v9i5.66

By:

Benkhouili, Fatima Zahra;
Moutawalli, Amina;
Benzeid, Hanane;
Doukkali, Anass;
Zahidi, Ahmed

Publication type:

Article

Antirheumatic Potential of Araucaria-Derived Biflavonoids through In Silico Docking to 20S Proteasome.

Published in:

Tropical Journal of Natural Product Research, 2025, v. 9, n. 5, p. 2043, doi. 10.26538/tjnpr/v9i5.24

By:

Irfana, Luthfan;
Suryawan, Chinesia P.;
Arifin, Budi;
Achmadi, Suminar S.;
Wahyudi, Setyanto T.;
Sugita, Purwantiningsih

Publication type:

Article

The Premise of the Paradox: Examining the Evidence That Motivated GIPR Agonist and Antagonist Drug Development Programs.

Published in:

Journal of Clinical Medicine, 2025, v. 14, n. 11, p. 3812, doi. 10.3390/jcm14113812

By:

Douros, Jonathan D.;
Mowery, Stephanie A.;
Knerr, Patrick J.

Publication type:

Article

Prediction of Interspecies Translation for Targeting Delivery Coefficients of GalNAc-siRNA Silencing Apolipoprotein C-III Using a Mechanistic Minimal Physiologically Based Pharmacokinetic/Pharmacodynamic Model.

Published in:

Clinical Pharmacokinetics, 2025, v. 64, n. 6, p. 865, doi. 10.1007/s40262-025-01513-4

By:

Tian, Zhiteng;
Luo, Hui;
Chu, Yantao;
Liu, Yanhong;
Gao, Shan;
Song, Ling;
Yang, Zhenzhen;
Liu, Dongyang

Publication type:

Article

槲皮素防治肝细胞癌相关信号通路研究进展.

Published in:

Evaluation & Analysis of Drug-Use in Hospitals of China / Zhongguo Yiyuan Yongyao Pingjia yu Fenxi, 2025, v. 25, n. 5, p. 632, doi. 10.14009/j.issn.1672-2124.2025.05.025

By:

姚三飞;
刘江凯

Publication type:

Article

A State-of-the-Art Review on Recent Biomedical Application of Polysaccharide-Based Niosomes as Drug Delivery Systems.

Published in:

Polymers (20734360), 2025, v. 17, n. 11, p. 1566, doi. 10.3390/polym17111566

By:

Iacob, Andreea-Teodora;
Ababei-Bobu, Andra;
Chirliu, Oana-Maria;
Lupascu, Florentina Geanina;
Vasincu, Ioana-Mirela;
Apotrosoaei, Maria;
Profire, Bianca-Stefania;
Tauser, Georgiana-Roxana;
Lupascu, Dan;
Profire, Lenuta

Publication type:

Article

Lymphatic Metastasis of Esophageal Squamous Cell Carcinoma: The Role of NRF2 and Therapeutic Strategies.

Published in:

Cancers, 2025, v. 17, n. 11, p. 1853, doi. 10.3390/cancers17111853

By:

Li, Yahui;
Ladd, Zachary;
Xiong, Zhaohui;
Bui-Linh, Candice;
Paiboonrungruang, Chorlada;
Subramaniyan, Boopathi;
Li, Huan;
Wang, Haining;
Balch, Curt;
Shersher, David D.;
Spitz, Francis;
Chen, Xiaoxin

Publication type:

Article

Personalized Treatment in Ovarian Cancer: A Review of Disease Monitoring, Biomarker Expression, and Targeted Treatments for Advanced, Recurrent Ovarian Cancers.

Published in:

Cancers, 2025, v. 17, n. 11, p. 1822, doi. 10.3390/cancers17111822

By:

Ettorre, Victoria M.;
AlAshqar, Abdelrahman;
Sethi, Namrata;
Santin, Alessandro D.

Publication type:

Article

Bacopa monnieri : Preclinical and Clinical Evidence of Neuroactive Effects, Safety of Use and the Search for Improved Bioavailability.

Published in:

Nutrients, 2025, v. 17, n. 11, p. 1939, doi. 10.3390/nu17111939

By:

Gościniak, Anna;
Stasiłowicz-Krzemień, Anna;
Szeląg, Marta;
Pawlak, Jakub;
Skiera, Izabela;
Kwiatkowska, Hanna;
Nowak, Natasza;
Bernady, Krzysztof;
Trzaskoma, Piotr;
Zimak-Krótkopad, Oskar;
Cielecka-Piontek, Judyta

Publication type:

Article

Aqueous Extract of Freshwater Clam Increases Alcohol Metabolism in Rats in a Preclinical Model.

Published in:

Nutrients, 2025, v. 17, n. 11, p. 1915, doi. 10.3390/nu17111915

By:

Chung, Pei-Ying;
Chiu, I-Chen;
Kuan, Ching-Yi;
Wu, Tsung-Meng;
Tseng, Kuo-Chan;
Chuang, Shu-Ting;
Tsai, Sen-Wei;
Chen, Yu-Kuo

Publication type:

Article

Anti-Inflammatory Potential of Essential Oil from the Heart-Wood of the Folk Medicinal Tree Cinnamomum kanehirai Hayata in Macrophages.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5419, doi. 10.3390/ijms26115419

By:

Liu, May-Lan;
Liu, Pang-Yen;
Chao, Louis Kuoping;
Yang, Tzu-Jung;
Li, Lan-Hui;
Weng, Yih-Ming;
Sommano, Sarana Rose;
Unpaprom, Yuwalee;
Ramaraj, Rameshprabu;
Ho, Chen-Lung;
Hua, Kuo-Feng

Publication type:

Article

Emerging Immunotherapy Targets in Early Drug Development.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5394, doi. 10.3390/ijms26115394

By:

Morchón-Araujo, Daniel;
Catani, Greta;
Mirallas, Oriol;
Pretelli, Giulia;
Sánchez-Pérez, Vicky;
Vieito, María;
Braña, Irene;
Pujol-Borrell, Ricardo;
Garralda, Elena;
Hernando-Calvo, Alberto

Publication type:

Article

Metabolic Imaging of Hyperpolarized [1- 13 C]Pyruvate in a Ferret Model of Traumatic Brain Injury.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5327, doi. 10.3390/ijms26115327

By:

Mayer, Dirk;
Eldirdiri, Abubakr;
Hrdlick, Amanda L.;
Piskoun, Boris;
Rogers, Joshua C.;
Jhajharia, Aditya;
Zhu, Minjie;
Proctor, Julie L.;
Leiste, Ulrich H.;
Fourney, William L.;
Cantu, Jody C.;
Fiskum, Gary;
Goodfellow, Molly J.

Publication type:

Article

Virtual Screening of Novel Benzothiozinone Derivatives to Predict Potential Inhibitors of Mycobacterium Tuberculosis Kinases 2D-QSAR, Molecular Docking, MM-PBSA Dynamics Simulations, and ADMET Properties.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5129, doi. 10.3390/ijms26115129

By:

Guendouzi, Abdelmadjid;
Belkhiri, Lotfi;
Slimani, Zakaria;
Guendouzi, Abdelkrim;
Moroy, Gautier

Publication type:

Article

Synthesis, In Vitro Anti-Inflammatory Activity, Molecular Docking, Molecular Dynamics and DFT Calculations of Thiazoline-2-Thione Derivatives.

Published in:

Applied Sciences (2076-3417), 2025, v. 15, n. 11, p. 6095, doi. 10.3390/app15116095

By:

Farial, Bahaz;
Lotfi, Bourougaa;
Takoua, Belghit;
Sameh, Hadjar;
Zinelaabidine, Cheraiet;
Mandumpal, Jestin;
Abdelfattah, Mohamed A. O.;
Maroua, Fattouche;
Abdelkrim, Gouasmia

Publication type:

Article

Anticancer Effects of Withanolides: In Silico Prediction of Pharmacological Properties.

Published in:

Molecules, 2025, v. 30, n. 11, p. 2457, doi. 10.3390/molecules30112457

By:

Silva, Gustavo Werneck de Souza e;
Marques, André Mesquita;
Sampaio, André Luiz Franco

Publication type:

Article

Bactericidal Effect of Synthetic Phenylalkylamides Inspired by Gibbilimbol B Against Neisseria gonorrhoeae.

Published in:

Molecules, 2025, v. 30, n. 11, p. 2406, doi. 10.3390/molecules30112406

By:

Oliveira, Larissa V. F.;
Tempone, Andre G.;
Christodoulides, Myron;
Lago, Joao Henrique G.

Publication type:

Article

Gating Mechanism for Biased Agonism at Angiotensin II Type 1 Receptors.

Published in:

Molecules, 2025, v. 30, n. 11, p. 2399, doi. 10.3390/molecules30112399

By:

Moore, Graham J.;
Ridgway, Harry;
Gadanec, Laura Kate;
Apostolopoulos, Vasso;
Zulli, Anthony;
Matsoukas, John M.

Publication type:

Article

Antimicrobial resistance and antimicrobial stewardship: an update.

Published in:

Wound Practice & Research, 2025, v. 33, n. 2, p. 79, doi. 10.33235/wpr.33.2.79-96

By:

Rippon, Mark G.;
Rogers, Alan A.;
Ousey, Karen

Publication type:

Article

SCATrans: semantic cross-attention transformer for drug–drug interaction predication through multimodal biomedical data.

Published in:

BMC Bioinformatics, 2025, v. 26, n. 1, p. 1, doi. 10.1186/s12859-025-06165-6

By:

Zhang, Shanwen;
Yu, Changqing;
Zhang, Chuanlei

Publication type:

Article

Wnt/β-catenin mediated signaling pathways in cancer: recent advances, and applications in cancer therapy.

Published in:

Molecular Cancer, 2025, v. 24, n. 1, p. 1, doi. 10.1186/s12943-025-02363-1

By:

Wu, Xiuzhu;
Que, Haiying;
Li, Qingfang;
Wei, Xiawei

Publication type:

Article

Brain injury biomarkers as targets for drugs development and personalized treatment for traumatic brain injury patients.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1606174

By:

Sandler, Melissa;
Almohaish, Sulaiman;
Brophy, Gretchen M.

Publication type:

Article

Optimization of automated patch-clamp technique and comparative analysis with manual patch-clamp: A case study on the TRPV1 channel.

Published in:

Journal of Chinese Pharmaceutical Sciences, 2025, v. 34, n. 5, p. 485, doi. 10.5246/jcps.2025.05.037

By:

Guifang Duan;
Yue Li;
Xia Yuan;
Shuxiang Song;
Yingli Xu;
Jianchun Zhou

Publication type:

Article

Sample-size determination for decentralized clinical trials.

Published in:

International Journal of Epidemiology, 2025, v. 54, n. 3, p. 1, doi. 10.1093/ije/dyaf053

By:

Tian, Feng;
Lin, Ruitao;
Liu, Suyu;
Yuan, Ying

Publication type:

Article

Cost and Duration of Clinical Trials in Drug Development by Japanese Pharmaceutical Companies.

Published in:

Pharmaceutical Medicine, 2025, v. 39, n. 3, p. 199, doi. 10.1007/s40290-025-00558-x

By:

Okada, Norihiro;
Takahashi, Yosuke

Publication type:

Article

Importance of Health Economics and Outcomes Research in the Product Lifecycle.

Published in:

Pharmaceutical Medicine, 2025, v. 39, n. 3, p. 157, doi. 10.1007/s40290-025-00564-z

By:

Dang, Amit

Publication type:

Article

"Regression to the truth": lessons learned from negative IPF trials.

Published in:

Breathe, 2025, v. 21, n. 2, p. 1, doi. 10.1183/20734735.0260-2024

By:

Trachalaki, Athina;
Lindahl, Anna L.;
Petrarulo, Simone;
Margaritopoulos, George A.

Publication type:

Article

Structural Basis of Sequential Enantioselective Epoxidation by a Flavin‐Dependent Monooxygenase in Lasalocid A Biosynthesis.

Published in:

Angewandte Chemie, 2025, v. 137, n. 24, p. 1, doi. 10.1002/ange.202504982

By:

Wang, Qian;
Deng, Yaming;
Viera, Dayan;
Liu, Xiaopeng;
Liu, Ning;
Hu, Yulu;
Hu, Xiangdong;
Wei, Hao;
Zhou, Quan;
Lan, Ting;
He, Wei;
Chen, Xi;
Kim, Chu‐Young

Publication type:

Article

Pathogenicity analysis of a Chinese Genogroup II Akabane virus strain (TJ2016) in mouse models.

Published in:

Virology Journal, 2025, v. 22, n. 1, p. 1, doi. 10.1186/s12985-025-02819-2

By:

Wang, Jingjing;
Yu, Ruyang;
Wei, Fang;
Chen, Dongjie;
Wu, Shaoqiang

Publication type:

Article

抗体医薬品の現状と課題.

Published in:

Research on Drug Interactions, 2025, v. 49, n. 1, p. 2

By:

佐藤祥子

Publication type:

Article

B7–H3 and c-MET in advanced prostate cancer: exploring possibilities of novel bi-specific drug development.

Published in:

European Journal of Medical Research, 2025, v. 30, n. 1, p. 1, doi. 10.1186/s40001-025-02729-7

By:

He, Weiying;
Li, Huiyu;
Sun, Wenjia;
Zhang, Yanggeling;
Wu, De;
Ao, Chunxia;
Wang, Jincheng;
Yang, Yanan;
Xiao, Xuexue;
Zhang, Luyao;
Yue, Junqiu;
Wang, Xiyuan

Publication type:

Article

A Flexible Method Using a Parametric Bootstrap for Reducing Bias in Adaptive Designs With Treatment Selection.

Published in:

Statistics in Biopharmaceutical Research, 2014, v. 6, n. 2, p. 163, doi. 10.1080/19466315.2014.897251

By:

Pickard, Michael D.;
Chang, Mark

Publication type:

Article

A Quantitative Process for Enhancing End of Phase 2 Decisions.

Published in:

Statistics in Biopharmaceutical Research, 2014, v. 6, n. 1, p. 67, doi. 10.1080/19466315.2013.852617

By:

Sabin, Tony;
Matcham, James;
Bray, Sarah;
Copas, Andrew;
Parmar, Mahesh K. B.

Publication type:

Article

Contributions of Robert T. O'Neill to the Evolution of Regulatory Statistical Science.

Published in:

Statistics in Biopharmaceutical Research, 2013, v. 5, n. 3, p. 262, doi. 10.1080/19466315.2013.818817

By:

Anello, Charles;
Junod, Suzanne

Publication type:

Article

Statistical Issues and Controversies in Active-Controlled, "Noninferiority" Trials.

Published in:

Statistics in Biopharmaceutical Research, 2013, v. 5, n. 3, p. 229, doi. 10.1080/19466315.2013.786651

By:

Carroll, Kevin J.

Publication type:

Article

Being Efficient About Efficacy Estimation.

Published in:

Statistics in Biopharmaceutical Research, 2013, v. 5, n. 3, p. 204, doi. 10.1080/19466315.2012.754726

By:

Senn, Stephen

Publication type:

Article

Is It Time to Revisit the Role of Interleukin-1 Inhibitors in Osteoarthritis?

Published in:

Diabetes, Metabolic Syndrome & Obesity: Targets & Therapy, 2025, v. 18, p. 1753, doi. 10.2147/DMSO.S520465

By:

Brom, Martin;
Saxer, Franziska;
Mindeholm, Linda;
Schieker, Matthias;
Conaghan, Philip G

Publication type:

Article

Fullerenes in vivo. Toxicity and protective effects.

Published in:

Nanotoxicology, 2025, v. 19, n. 3, p. 233, doi. 10.1080/17435390.2025.2471273

By:

Bolshakova, Olga;
Zherebyatieva, Olga;
Sarantseva, Svetlana V.

Publication type:

Article

基于CRISPR-Cas系统的多重耐药菌防治技术研究进展.

Published in:

Biotechnology Bulletin, 2025, v. 41, n. 5, p. 42, doi. 10.13560/j.cnki.biotech.bull.1985.2024-0872

By:

周倩;
唐梦君;
张小燕;
陆俊贤;
唐修君;
杨星星;
高玉时

Publication type:

Article

Optimizing enzyme inhibition analysis: precise estimation with a single inhibitor concentration.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60468-z

By:

Jang, Hyeong Jun;
Song, Yun Min;
Jeon, Jang Su;
Yun, Hwi-yeol;
Kim, Sang Kyum;
Kim, Jae Kyoung

Publication type:

Article

A comprehensive antigen-antibody complex database unlocking insights into interaction interface.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.104934

By:

Yuwei Zhou;
Wenwen Liu;
Ziru Huang;
Yushu Gou;
Siqi Liu;
Lixu Jiang;
Yue Yang;
Jian Huang

Publication type:

Article