Works matching AU Matthews, Keith R.

Results: 43

Trypanosomal immune evasion, chronicity and transmission: an elegant balancing act.

Published in:

Nature Reviews Microbiology, 2012, v. 10, n. 6, p. 431, doi. 10.1038/nrmicro2779

By:

MacGregor, Paula;
Szö?r, Balazs;
Savill, Nicholas J.;
Matthews, Keith R.

Publication type:

Article

Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts.

Published in:

Virulence, 2023, v. 14, n. 1, p. 1, doi. 10.1080/21505594.2022.2150445

By:

Morrison, Liam J.;
Steketee, Pieter C.;
Tettey, Mabel D.;
Matthews, Keith R.

Publication type:

Article

Harnessing evolutionary biology to combat infectious disease.

Published in:

2012

By:

Little, Tom J;
Allen, Judith E;
Babayan, Simon A;
Matthews, Keith R;
Colegrave, Nick

Publication type:

Opinion

Independent Pathways Can Transduce the Life-Cycle Differentiation Signal in <i>Trypanosoma brucei</i>.

Published in:

PLoS Pathogens, 2013, v. 9, n. 10, p. 1, doi. 10.1371/journal.ppat.1003689

By:

Szöőr, Balazs;
Dyer, Naomi A.;
Ruberto, Irene;
Acosta-Serrano, Alvaro;
Matthews, Keith R.

Publication type:

Article

Targeting Cattle-Borne Zoonoses and Cattle Pathogens Using a Novel Trypanosomatid-Based Delivery System.

Published in:

PLoS Pathogens, 2011, v. 7, n. 10, p. 1, doi. 10.1371/journal.ppat.1002340

By:

Mott, G. Adam;
Wilson, Raymond;
Fernando, Anuruddika;
Robinson, Ailie;
MacGregor, Paula;
Kennedy, David;
Schaap, Dick;
Matthews, Jacqueline B.;
Matthews, Keith R.

Publication type:

Article

Differential Trypanosome Surface Coat Regulation by a CCCH Protein That Co-Associates with procyclin mRNA cis-Elements.

Published in:

PLoS Pathogens, 2009, v. 5, n. 2, p. 1, doi. 10.1371/journal.ppat.1000317

By:

Walrad, Pegine;
Paterou, Athina;
Acosta-Serrano, Alvaro;
Matthews, Keith R.

Publication type:

Article

Protein tyrosine phosphatase TbPTP1: a molecular switch controlling life cycle differentiation in trypanosomes.

Published in:

Journal of Cell Biology, 2006, v. 175, n. 2, p. 293

By:

Szöőr, Balázs;
Wilson, Jude;
McElhinney, Helen;
Tabernero, Lydia;
Matthews, Keith R.

Publication type:

Article

Comment on 'Unexpected plasticity in the life cycle of Trypanosoma brucei'.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.74985

By:

Matthews, Keith R.;
Larcombe, Stephen

Publication type:

Article

Extracellular release of two peptidases dominates generation of the trypanosome quorum-sensing signal.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-31057-1

By:

Tettey, Mabel Deladem;
Rojas, Federico;
Matthews, Keith R.

Publication type:

Article

Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25607-2

By:

Briggs, Emma M.;
Rojas, Federico;
McCulloch, Richard;
Matthews, Keith R.;
Otto, Thomas D.

Publication type:

Article

Long Title: Cas10 based 7SL-sRNA diagnostic for the detection of active trypanosomosis.

Published in:

PLoS Neglected Tropical Diseases, 2025, v. 19, n. 3, p. 1, doi. 10.1371/journal.pntd.0012937

By:

Grüschow, Sabine;
Steketee, Pieter C.;
Paxton, Edith;
Matthews, Keith R.;
Morrison, Liam J.;
White, Malcolm F.;
Grey, Finn

Publication type:

Article

Regulation of <i>Trypanosoma brucei</i> Total and Polysomal mRNA during Development within Its Mammalian Host.

Published in:

PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0067069

By:

Capewell, Paul;
Monk, Stephanie;
Ivens, Alasdair;
MacGregor, Paula;
Fenn, Katelyn;
Walrad, Pegine;
Bringaud, Frederic;
Smith, Terry K.;
Matthews, Keith R.

Publication type:

Article

The Trypanosome Rab-Related Proteins RabX1 and RabX2 Play No Role in IntraCellular Trafficking but May Be Involved in Fly Infectivity.

Published in:

PLoS ONE, 2009, v. 4, n. 9, p. 1, doi. 10.1371/journal.pone.0007217

By:

Natesan, Senthil Kumar A.;
Peacock, Lori;
Ka Fai Leung;
Matthews, Keith R.;
Gibson, Wendy;
Field, Mark C.

Publication type:

Article

Investigating Mammalian Tyrosine Phosphatase Inhibitors as Potential 'Piggyback' Leads to Target Trypanosoma brucei Transmission.

Published in:

Chemical Biology & Drug Design, 2013, v. 81, n. 2, p. 291, doi. 10.1111/cbdd.12079

By:

Ruberto, Irene;
Szoor, Balazs;
Clark, Rachel;
Matthews, Keith R.

Publication type:

Article

Consistent detection of Trypanosoma brucei but not T. congolense DNA in faeces of experimentally infected cattle.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-54857-5

By:

Saldanha, Isabel;
Betson, Martha;
Vrettou, Christina;
Paxton, Edith;
Nixon, James;
Tennant, Peter;
Ritchie, Adrian;
Matthews, Keith R.;
Morrison, Liam J.;
Torr, Stephen J.;
Cunningham, Lucas J.

Publication type:

Article

Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei.

Published in:

Frontiers in Cellular & Infection Microbiology, 2013, v. 3, p. 1, doi. 10.3389/fcimb.2013.00078

By:

Rico, Eva;
Rojas, Federico;
Mony, Binny M.;
Szoor, Balazs;
MacGregor, Paula;
Matthews, Keith R.

Publication type:

Article

Disruption of the developmental programme of Trypanosoma brucei by genetic ablation of TbZFP1, a differentiation-enriched CCCH protein.

Published in:

Molecular Microbiology, 2005, v. 57, n. 3, p. 706, doi. 10.1111/j.1365-2958.2005.04679.x

By:

Hendriks, Edward F.;
Matthews, Keith R.

Publication type:

Article

African trypanosomes.

Published in:

Parasites & Vectors, 2019, v. 12, n. 1, p. N.PAG, doi. 10.1186/s13071-019-3355-5

By:

Cayla, Mathieu;
Rojas, Federico;
Silvester, Eleanor;
Venter, Frank;
Matthews, Keith R.

Publication type:

Article

Targeting pathogen metabolism without collateral damage to the host.

Published in:

Scientific Reports, 2017, p. 40406, doi. 10.1038/srep40406

By:

Haanstra, Jurgen R.;
Gerding, Albert;
Dolga, Amalia M.;
Sorgdrager, Freek J. H.;
Buist-Homan, Manon;
du Toit, François;
Faber, Klaas Nico;
Holzhütter, Hermann-Georg;
Szöör, Balázs;
Matthews, Keith R.;
Snoep, Jacky L.;
Westerhoff, Hans V.;
Bakker, Barbara M.

Publication type:

Article

Mitochondrial DNA is critical for longevity and metabolism of transmission stage Trypanosoma brucei.

Published in:

PLoS Pathogens, 2018, v. 14, n. 7, p. 1, doi. 10.1371/journal.ppat.1007195

By:

Dewar, Caroline E.;
MacGregor, Paula;
Cooper, Sinclair;
Gould, Matthew K.;
Matthews, Keith R.;
Savill, Nicholas J.;
Schnaufer, Achim

Publication type:

Article

Non-linear hierarchy of the quorum sensing signalling pathway in bloodstream form African trypanosomes.

Published in:

PLoS Pathogens, 2018, v. 14, n. 6, p. 1, doi. 10.1371/journal.ppat.1007145

By:

McDonald, Lindsay;
Cayla, Mathieu;
Ivens, Alasdair;
Mony, Binny;
MacGregor, Paula;
Silvester, Eleanor;
McWilliam, Kirsty;
Matthews, Keith R.

Publication type:

Article

Assembling the components of the quorum sensing pathway in African trypanosomes.

Published in:

Molecular Microbiology, 2015, v. 96, n. 2, p. 220, doi. 10.1111/mmi.12949

By:

Mony, Binny M.;
Matthews, Keith R.

Publication type:

Article

A novel CCCH protein which modulates differentiation of Trypanosoma brucei to its procyclic form.

Published in:

EMBO Journal, 2001, v. 20, n. 23, p. 6700, doi. 10.1093/emboj/20.23.6700

By:

Hendriks, Edward F.;
Robinson, Derrick R.;
Hinkins, Matthew;
Matthews, Keith R.

Publication type:

Article

Molecular control of irreversible bistability during trypanosome developmental commitment.

Published in:

Journal of Cell Biology, 2015, v. 211, n. 2, p. 455, doi. 10.1083/jcb.201506114

By:

Domingo-Sananes, Maria Rosa;
Szöőr, Balazs;
Ferguson, Michael A. J.;
Urbaniak, Michael D.;
Matthews, Keith R.

Publication type:

Article

The Cytological Events and Molecular Control of Life Cycle Development of Trypanosoma brucei in the Mammalian Bloodstream.

Published in:

Pathogens, 2017, v. 6, n. 3, p. 29, doi. 10.3390/pathogens6030029

By:

Silvester, Eleanor;
McWilliam, Kirsty R.;
Matthews, Keith R.

Publication type:

Article

Inter-chromosomal transcription hubs shape the 3D genome architecture of African trypanosomes.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-55285-9

By:

Rabuffo, Claudia;
Schmidt, Markus R.;
Yadav, Prateek;
Tong, Pin;
Carloni, Roberta;
Barcons-Simon, Anna;
Cosentino, Raúl O.;
Krebs, Stefan;
Matthews, Keith R.;
Allshire, Robin C.;
Siegel, T. Nicolai

Publication type:

Article

Mechanisms of life cycle simplification in African trypanosomes.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-54555-w

By:

Oldrieve, Guy R.;
Venter, Frank;
Cayla, Mathieu;
Verney, Mylène;
Hébert, Laurent;
Geerts, Manon;
Van Reet, Nick;
Matthews, Keith R.

Publication type:

Article

A gene expression comparison of Trypanosoma brucei and Trypanosoma congolense in the bloodstream of the mammalian host reveals species-specific adaptations to density-dependent development.

Published in:

PLoS Neglected Tropical Diseases, 2018, v. 12, n. 10, p. 1, doi. 10.1371/journal.pntd.0006863

By:

Silvester, Eleanor;
Ivens, Alasdair;
Matthews, Keith R.

Publication type:

Article

A conserved trypanosomatid differentiation regulator controls substrate attachment and morphological development in Trypanosoma congolense.

Published in:

PLoS Pathogens, 2024, v. 20, n. 2, p. 1, doi. 10.1371/journal.ppat.1011889

By:

Silvester, Eleanor;
Szoor, Balazs;
Ivens, Alasdair;
Awuah-Mensah, Georgina;
Gadelha, Catarina;
Wickstead, Bill;
Matthews, Keith R.

Publication type:

Article

Profiling the bloodstream form and procyclic form Trypanosoma brucei cell cycle using single-cell transcriptomics.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.86325

By:

Briggs, Emma M.;
Marques, Catarina A.;
Oldrieve, Guy R.;
Jihua Hu;
Otto, Thomas D.;
Matthews, Keith R.

Publication type:

Article

The SPARC complex defines RNAPII promoters in Trypanosoma brucei.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.83135

By:

Staneva, Desislava P.;
Bresson, Stefan;
Auchynnikava, Tatsiana;
Spanos, Christos;
Rappsilber, Juri;
Jeyaprakash, A. Arockia;
Tollervey, David;
Matthews, Keith R.;
Allshire, Robin C.

Publication type:

Article

Basement membrane proteins as a substrate for efficient Trypanosoma brucei differentiation in vitro.

Published in:

PLoS Neglected Tropical Diseases, 2021, v. 15, n. 4, p. 1, doi. 10.1371/journal.pntd.0009284

By:

Rojas, Federico;
Cayla, Mathieu;
Matthews, Keith R.

Publication type:

Article

Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei.

Published in:

PLoS Pathogens, 2017, v. 13, n. 3, p. 1, doi. 10.1371/journal.ppat.1006279

By:

Rico, Eva;
Ivens, Alasdair;
Glover, Lucy;
Horn, David;
Matthews, Keith R.

Publication type:

Article

A surface transporter family conveys the trypanosome differentiation signal.

Published in:

Nature, 2009, v. 459, n. 7244, p. 213, doi. 10.1038/nature07997

By:

Dean, Samuel;
Marchetti, Rosa;
Kirk, Kiaran;
Matthews, Keith R.

Publication type:

Article

TrAGEDy—trajectory alignment of gene expression dynamics.

Published in:

Bioinformatics, 2025, v. 41, n. 3, p. 1, doi. 10.1093/bioinformatics/btaf073

By:

Laidlaw, Ross F;
Briggs, Emma M;
Matthews, Keith R;
Mamlouk, Amir Madany;
McCulloch, Richard;
Otto, Thomas D

Publication type:

Article

Application of single-cell transcriptomics to kinetoplastid research.

Published in:

Parasitology, 2021, v. 148, n. 10, p. 1223, doi. 10.1017/S003118202100041X

By:

Briggs, Emma M.;
Warren, Felix S. L.;
Matthews, Keith R.;
McCulloch, Richard;
Otto, Thomas D.

Publication type:

Article

Differentiation granules, a dynamic regulator of T. brucei development.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-47309-1

By:

Cayla, Mathieu;
Spanos, Christos;
McWilliam, Kirsty;
Waskett, Eliza;
Rappsilber, Juri;
Matthews, Keith R.

Publication type:

Article

A Continued Fractions Approach to a Result of Feit.

Published in:

American Mathematical Monthly, 2008, v. 115, n. 4, p. 346, doi. 10.1080/00029890.2008.11920534

By:

Robertson, John P.;
Matthews, Keith R.

Publication type:

Article

New discoveries in the transmission biology of sleeping sickness parasites: applying the basics.

Published in:

Journal of Molecular Medicine, 2010, v. 88, n. 9, p. 865, doi. 10.1007/s00109-010-0637-y

By:

MacGregor, Paula;
Matthews, Keith R.

Publication type:

Article

NMD3 regulates both mRNA and rRNA nuclear export in African trypanosomes via an XPOI-linked pathway.

Published in:

Nucleic Acids Research, 2015, v. 43, n. 9, p. 4491, doi. 10.1093/nar/gkv330

By:

Bühlmann, Melanie;
Walrad, Pegine;
Rico, Eva;
Ivens, Alasdair;
Capewell, Paul;
Naguleswaran, Arunasalam;
Roditi, Isabel;
Matthews, Keith R.

Publication type:

Article

Identification of the regulatory elements controlling the transmission stage-specific gene expression of PAD1 in Trypanosoma brucei.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 16, p. 7705, doi. 10.1093/nar/gks533

By:

MacGregor, Paula;
Matthews, Keith R.

Publication type:

Article

The post-transcriptional trans-acting regulator, TbZFP3, co-ordinates transmission-stage enriched mRNAs in Trypanosoma brucei.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 7, p. 2869, doi. 10.1093/nar/gkr1106

By:

Walrad, Pegine B.;
Capewell, Paul;
Fenn, Katelyn;
Matthews, Keith R.

Publication type:

Article

ON THE OPTIMAL CONTINUED FRACTION EXPANSION OF A QUADRATIC SURD.

Published in:

Journal of the Australian Mathematical Society, 2012, v. 93, n. 1/2, p. 133, doi. 10.1017/S1446788712000596

By:

MATTHEWS, KEITH R.

Publication type:

Article