Works matching DE "REPLICATION fork"

Results: 61

An additional replication origin causes cell cycle specific DNA replication fork speed.

Published in:

Frontiers in Microbiology, 2025, p. 1, doi. 10.3389/fmicb.2025.1584664

By:

Skovgaard, Ole

Publication type:

Article

DNA glycosylase (NEIL3) overexpression associated with low tumor immune infiltration and poor overall patient survival in endometrial cancer.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-00393-9

By:

Barry, Cristofer;
Shahi, Aashirwad;
Kidane, Dawit

Publication type:

Article

Transcription Factor Inhibition as a Potential Additional Mechanism of Action of Pyrrolobenzodiazepine (PBD) Dimers.

Published in:

DNA (2673-8856), 2025, v. 5, n. 1, p. 8, doi. 10.3390/dna5010008

By:

Mantaj, Julia;
Jackson, Paul J. M.;
Parsons, Richard B.;
Bui, Tam T. T.;
Thurston, David E.;
Rahman, Khondaker Miraz

Publication type:

Article

Reversion from basal histone H4 hypoacetylation at the replication fork increases DNA damage in FANCA deficient cells.

Published in:

PLoS ONE, 2024, v. 19, n. 5, p. 1, doi. 10.1371/journal.pone.0298032

By:

Teresa, Benilde García-de;
Ayala-Zambrano, Cecilia;
González-Suárez, Mirna;
Molina, Bertha;
Torres, Leda;
Rodríguez, Alfredo;
Frías, Sara

Publication type:

Article

Topoisomerase IV tracks behind the replication fork and the SeqA complex during DNA replication in Escherichia coli.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-020-80043-4

By:

Helgesen, Emily;
Sætre, Frank;
Skarstad, Kirsten

Publication type:

Article

Balancing act: BRCA2's elaborate management of telomere replication through control of G‐quadruplex dynamicity.

Published in:

BioEssays, 2024, v. 46, n. 8, p. 1, doi. 10.1002/bies.202300229

By:

Joo, So Young;
Sung, Keewon;
Lee, Hyunsook

Publication type:

Article

Replication Fork Barriers and Topological Barriers: Progression of DNA Replication Relies on DNA Topology Ahead of Forks.

Published in:

BioEssays, 2020, v. 42, n. 5, p. 1, doi. 10.1002/bies.201900204

By:

Schvartzman, Jorge B.;
Hernández, Pablo;
Krimer, Dora B.

Publication type:

Article

Replication stress as a driver of cellular senescence and aging.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-06263-w

By:

Herr, Lauren M.;
Schaffer, Ethan D.;
Fuchs, Kathleen F.;
Datta, Arindam;
Brosh Jr., Robert M.

Publication type:

Article

BMP signaling promotes zebrafish heart regeneration via alleviation of replication stress.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-56993-6

By:

Vasudevarao, Mohankrishna Dalvoy;
Posadas Pena, Denise;
Ihle, Michaela;
Bongiovanni, Chiara;
Maity, Pallab;
Geissler, Dominik;
Mohammadi, Hossein Falah;
Rall-Scharpf, Melanie;
Niemann, Julian;
Mommersteeg, Mathilda T. M.;
Redaelli, Simone;
Happ, Kathrin;
Wu, Chi-Chung;
Beisaw, Arica;
Scharffetter-Kochanek, Karin;
D'Uva, Gabriele;
Malek Mohammadi, Mona;
Wiesmüller, Lisa;
Geiger, Hartmut;
Weidinger, Gilbert

Publication type:

Article

Replication-IDentifier links epigenetic and metabolic pathways to the replication stress response.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-56561-y

By:

van der Horst, Sophie C.;
Kollenstart, Leonie;
Batté, Amandine;
Keizer, Sander;
Vreeken, Kees;
Pandey, Praveen;
Chabes, Andrei;
van Attikum, Haico

Publication type:

Article

Molecular mechanism of parental H3/H4 recycling at a replication fork.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-53187-4

By:

Nagae, Fritz;
Murayama, Yasuto;
Terakawa, Tsuyoshi

Publication type:

Article

MCM2-7 loading-dependent ORC release ensures genome-wide origin licensing.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-51538-9

By:

Reuter, L. Maximilian;
Khadayate, Sanjay P.;
Mossler, Audrey;
Liebl, Korbinian;
Faull, Sarah V.;
Karimi, Mohammad M.;
Speck, Christian

Publication type:

Article

DSS1 restrains BRCA2's engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasis.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-51557-6

By:

Huang, Yuxin;
Li, Wenjing;
Foo, Tzeh;
Ji, Jae-Hoon;
Wu, Bo;
Tomimatsu, Nozomi;
Fang, Qingming;
Gao, Boya;
Long, Melissa;
Xu, Jingfei;
Maqbool, Rouf;
Mukherjee, Bipasha;
Ni, Tengyang;
Alejo, Salvador;
He, Yuan;
Burma, Sandeep;
Lan, Li;
Xia, Bing;
Zhao, Weixing

Publication type:

Article

PARP1-dependent DNA-protein crosslink repair.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50912-x

By:

Fábián, Zita;
Kakulidis, Ellen S.;
Hendriks, Ivo A.;
Kühbacher, Ulrike;
Larsen, Nicolai B.;
Oliva-Santiago, Marta;
Wang, Junhui;
Leng, Xueyuan;
Dirac-Svejstrup, A. Barbara;
Svejstrup, Jesper Q.;
Nielsen, Michael L.;
Caldecott, Keith;
Duxin, Julien P.

Publication type:

Article

Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50882-0

By:

Machour, Feras E.;
R. Abu-Zhayia, Enas;
Kamar, Joyce;
Barisaac, Alma Sophia;
Simon, Itamar;
Ayoub, Nabieh

Publication type:

Article

Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge.

Published in:

Nature Communications, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41467-024-50575-8

By:

Hong, Zebin;
Byrd, Alicia K.;
Gao, Jun;
Das, Poulomi;
Tan, Vanessa Qianmin;
Malone, Emory G.;
Osei, Bertha;
Marecki, John C.;
Protacio, Reine U.;
Wahls, Wayne P.;
Raney, Kevin D.;
Song, Haiwei

Publication type:

Article

DCAF15 control of cohesin dynamics sustains acute myeloid leukemia.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-49882-x

By:

Grothusen, Grant P.;
Chang, Renxu;
Cao, Zhendong;
Zhou, Nan;
Mittal, Monika;
Datta, Arindam;
Wulfridge, Phillip;
Beer, Thomas;
Wang, Baiyun;
Zheng, Ning;
Tang, Hsin-Yao;
Sarma, Kavitha;
Greenberg, Roger A.;
Shi, Junwei;
Busino, Luca

Publication type:

Article

Fate of telomere entanglements is dictated by the timing of anaphase midregion nuclear envelope breakdown.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-48382-2

By:

Nageshan, Rishi Kumar;
Ortega, Raquel;
Krogan, Nevan;
Cooper, Julia Promisel

Publication type:

Article

H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-48715-1

By:

Dibitetto, Diego;
Liptay, Martin;
Vivalda, Francesca;
Dogan, Hülya;
Gogola, Ewa;
González Fernández, Martín;
Duarte, Alexandra;
Schmid, Jonas A.;
Decollogny, Morgane;
Francica, Paola;
Przetocka, Sara;
Durant, Stephen T.;
Forment, Josep V.;
Klebic, Ismar;
Siffert, Myriam;
de Bruijn, Roebi;
Kousholt, Arne N.;
Marti, Nicole A.;
Dettwiler, Martina;
Sørensen, Claus S.

Publication type:

Article

Flap endonuclease 1 and DNA-PKcs synergistically participate in stabilizing replication fork to encounter replication stress in glioma cells.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2022, v. 41, n. 1, p. 1, doi. 10.1186/s13046-022-02334-0

By:

Zhang, Jing;
Chen, Mu;
Pang, Ying;
Cheng, Meng;
Huang, Bingsong;
Xu, Siyi;
Liu, Min;
Lian, Hao;
Zhong, Chunlong

Publication type:

Article

Super-resolution visualization of distinct stalled and broken replication fork structures.

Published in:

PLoS Genetics, 2020, v. 16, n. 12, p. 1, doi. 10.1371/journal.pgen.1009256

By:

Whelan, Donna R.;
Lee, Wei Ting C.;
Marks, Frances;
Kong, Yu Tina;
Yin, Yandong;
Rothenberg, Eli

Publication type:

Article

Classical and novel properties of Holliday junction resolvase SynRuvC from Synechocystis sp. PCC6803.

Published in:

Frontiers in Microbiology, 2024, p. 1, doi. 10.3389/fmicb.2024.1362880

By:

Yanchao Gu;
Yantao Yang;
Chunhua Kou;
Ying Peng;
Wenguang Yang;
Jiayu Zhang;
Han Jin;
Xiaoru Han;
Yao Wang;
Xihui Shen

Publication type:

Article

Combined inhibition of RAD51 and CHK1 causes synergistic toxicity in cisplatin resistant cancer cells by triggering replication fork collapse.

Published in:

International Journal of Cancer, 2025, v. 156, n. 2, p. 389, doi. 10.1002/ijc.35164

By:

Mann, Julia;
Niedermayer, Kathrin;
Krautstrunk, Johannes;
Abbey, Lena;
Wiesmüller, Lisa;
Piekorz, Roland P.;
Fritz, Gerhard

Publication type:

Article

Molecular mechanisms of eukaryotic origin initiation, replication fork progression, and chromatin maintenance.

Published in:

Biochemical Journal, 2020, v. 477, n. 18, p. 3499, doi. 10.1042/BCJ20200065

By:

Zuanning Yuan;
Huilin Li

Publication type:

Article

Point Mutations V546E and D547H of the RBM-B Motif Do Not Affect the Binding of PrimPol to RPA and DNA.

Published in:

Molecular Biology, 2024, v. 58, n. 5, p. 961, doi. 10.1134/S0026893324700493

By:

Manukyan, A. A.;
Makarova, A. V.;
Boldinova, E. O.

Publication type:

Article

Identification of replication fork-associated proteins in Drosophila embryos and cultured cells using iPOND coupled to quantitative mass spectrometry.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-10821-9

By:

Munden, Alexander;
Wright, Madison T.;
Han, Dongsheng;
Tirgar, Reyhaneh;
Plate, Lars;
Nordman, Jared T.

Publication type:

Article

Assembly, Activation, and Helicase Actions of MCM2-7: Transition from Inactive MCM2-7 Double Hexamers to Active Replication Forks.

Published in:

Biology (2079-7737), 2024, v. 13, n. 8, p. 629, doi. 10.3390/biology13080629

By:

You, Zhiying;
Masai, Hisao

Publication type:

Article

A Decade of Discovery—Eukaryotic Replisome Disassembly at Replication Termination.

Published in:

Biology (2079-7737), 2024, v. 13, n. 4, p. 233, doi. 10.3390/biology13040233

By:

Jones, Rebecca M.;
Reynolds-Winczura, Alicja;
Gambus, Agnieszka

Publication type:

Article

Towards a Structural Mechanism for Sister Chromatid Cohesion Establishment at the Eukaryotic Replication Fork.

Published in:

Biology (2079-7737), 2021, v. 10, n. 6, p. 466, doi. 10.3390/biology10060466

By:

Henrikus, Sarah S.;
Costa, Alessandro

Publication type:

Article

The unfolded protein response of the endoplasmic reticulum protects Caenorhabditis elegans against DNA damage caused by stalled replication forks.

Published in:

G3: Genes | Genomes | Genetics, 2024, v. 14, n. 4, p. 1, doi. 10.1093/g3journal/jkae017

By:

Xu, Jiaming;
Sabatino, Brendil;
Yan, Junran;
Ermakova, Glafira;
Doering, Kelsie R S;
Taubert, Stefan

Publication type:

Article

RAD51 is a druggable target that sustains replication fork progression upon DNA replication stress.

Published in:

PLoS ONE, 2022, v. 17, n. 8, p. 1, doi. 10.1371/journal.pone.0266645

By:

Feu, Sonia;
Unzueta, Fernando;
Ercilla, Amaia;
Pérez-Venteo, Alejandro;
Jaumot, Montserrat;
Agell, Neus

Publication type:

Article

Structure of HIRAN domain of human HLTF bound to duplex DNA provides structural basis for DNA unwinding to initiate replication fork regression.

Published in:

Journal of Biochemistry, 2020, v. 167, n. 6, p. 597, doi. 10.1093/jb/mvaa008

By:

Hishiki, Asami;
Sato, Mamoru;
Hashimoto, Hiroshi

Publication type:

Article

Gallic acid inhibits Staphylococcus aureus RecA protein functions: Role in countering antibiotic resistance in bacteria.

Published in:

Journal of Applied Microbiology, 2024, v. 135, n. 6, p. 1, doi. 10.1093/jambio/lxad227

By:

Kiran, Kajal;
Patil, K Neelakanteshwar

Publication type:

Article

Nucleosome positioning at the replication fork.

Published in:

EMBO Journal, 2001, v. 20, n. 24, p. 7294, doi. 10.1093/emboj/20.24.7294

By:

Lucchini, Renzo;
Wellinger, Ralf Erik;
Sogo, José M.

Publication type:

Article

The Yeast HMGB Protein Hmo1 Is a Multifaceted Regulator of DNA Damage Tolerance.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 7, p. 3255, doi. 10.3390/ijms26073255

By:

Huo, Jinlong;
Wei, Anhui;
Guo, Na;
Wang, Ruotong;
Bi, Xin

Publication type:

Article

Kinetic Features of Degradation of R-Loops by RNase H1 from Escherichia coli.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 22, p. 12263, doi. 10.3390/ijms252212263

By:

Kuznetsova, Aleksandra A.;
Kosarev, Iurii A.;
Timofeyeva, Nadezhda A.;
Novopashina, Darya S.;
Kuznetsov, Nikita A.

Publication type:

Article

Effects of PCNA Stability on the Formation of Mutations.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 16, p. 8646, doi. 10.3390/ijms25168646

By:

Arbel-Groissman, Matan;
Liefshitz, Batia;
Kupiec, Martin

Publication type:

Article

Role and Regulation of Pif1 Family Helicases at the Replication Fork.

Published in:

2022

By:

Malone, Emory G.;
Thompson, Matthew D.;
Byrd, Alicia K.

Publication type:

Literature Review

The H. pylori CagA Oncoprotein Induces DNA Double Strand Breaks through Fanconi Anemia Pathway Downregulation and Replication Fork Collapse.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 3, p. 1661, doi. 10.3390/ijms23031661

By:

Kolinjivadi, Arun Mouli;
Sankar, Haresh;
Choudhary, Ramveer;
Tay, Lavina Sierra;
Tan, Tuan Zea;
Murata-Kamiya, Naoko;
Voon, Dominic Chih-Cheng;
Kappei, Dennis;
Hatakeyama, Masanori;
Krishnan, Vaidehi;
Ito, Yoshiaki

Publication type:

Article

XRCC1 Prevents Replication Fork Instability during Misincorporation of the DNA Demethylation Bases 5-Hydroxymethyl-2′-Deoxycytidine and 5-Hydroxymethyl-2′-Deoxyuridine.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 2, p. 893, doi. 10.3390/ijms23020893

By:

Peña-Gómez, María José;
Suárez-Pizarro, Marina;
Rosado, Iván V.

Publication type:

Article

Delineation of the Ancestral Tus-Dependent Replication Fork Trap.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 24, p. 13533, doi. 10.3390/ijms222413533

By:

Toft, Casey J.;
Moreau, Morgane J. J.;
Perutka, Jiri;
Mandapati, Savitri;
Enyeart, Peter;
Sorenson, Alanna E.;
Ellington, Andrew D.;
Schaeffer, Patrick M.

Publication type:

Article

From R-Loops to G-Quadruplexes: Emerging New Threats for the Replication Fork.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 4, p. 1506, doi. 10.3390/ijms21041506

By:

Maffia, Antonio;
Ranise, Cecilia;
Sabbioneda, Simone

Publication type:

Article

Multifaceted role of the DNA replication protein MCM10 in maintaining genome stability and its implication in human diseases.

Published in:

Cancer & Metastasis Reviews, 2024, v. 43, n. 4, p. 1353, doi. 10.1007/s10555-024-10209-3

By:

Ahmed, Sumayyah M. Q.;
Sasikumar, Jayaprakash;
Laha, Suparna;
Das, Shankar Prasad

Publication type:

Article

PARP inhibition-associated heterochromatin confers increased DNA replication stress and vulnerability to ATR inhibition in SMARCA4-deficient cells.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02306-1

By:

Yano, Kimiyoshi;
Kato, Megumi;
Endo, Syoju;
Igarashi, Taichi;
Wada, Ryoga;
Kohno, Takashi;
Zimmermann, Astrid;
Dahmen, Heike;
Zenke, Frank T.;
Shiotani, Bunsyo

Publication type:

Article

Interferon-stimulated gene 15 accelerates replication fork progression inducing chromosomal breakage.

Published in:

Journal of Cell Biology, 2020, v. 219, n. 8, p. 1, doi. 10.1083/jcb.202002175

By:

Raso, Maria Chiara;
Djoric, Nikola;
Walser, Franziska;
Hess, Sandra;
Schmid, Fabian Marc;
Burger, Sibylle;
Knobeloch, Klaus-Peter;
Penengo, Lorenza

Publication type:

Article

MT1-MMP-dependent ECM processing regulates laminB1 stability and mediates replication fork restart.

Published in:

PLoS ONE, 2021, v. 16, n. 7, p. 1, doi. 10.1371/journal.pone.0253062

By:

Thakur, Varsha;
Tiburcio de Freitas, Juliano;
Li, Yuan;
Zhang, Keman;
Savadelis, Alyssa;
Bedogni, Barbara

Publication type:

Article

A Rfa1-MN–based system reveals new factors involved in the rescue of broken replication forks.

Published in:

PLoS Genetics, 2025, v. 21, n. 4, p. 1, doi. 10.1371/journal.pgen.1011405

By:

Amiama-Roig, Ana;
Barrientos-Moreno, Marta;
Cruz-Zambrano, Esther;
López-Ruiz, Luz M.;
González-Prieto, Román;
Ríos-Orelogio, Gabriel;
Prado, Félix

Publication type:

Article

Genetic Interaction Between F‐Box Encoding UCC1 and RRM3 Regulates Growth Rate, Cell Size, and Stress Tolerance in Saccharomyces cerevisiae.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 12, p. 1, doi. 10.1002/jbt.70059

By:

Pandita, Monika;
Shoket, Heena;
Kumar, Rakesh;
Bairwa, Narendra K.

Publication type:

Article

Effects of insulin-like growth factor 1 on proliferation of different cell lines.

Published in:

Biopolymers & Cell, 2024, v. 40, n. 3, p. 183, doi. 10.7124/bc.000ABE

By:

Kachalova, O. A.;
Moiseieva, T.;
Portnychenko, A. G.

Publication type:

Article

Crucial role of the NSE1 RING domain in Smc5/6 stability and FANCM-independent fork progression.

Published in:

Cellular & Molecular Life Sciences, 2024, v. 81, n. 1, p. 1, doi. 10.1007/s00018-024-05275-3

By:

Lorite, Neus P;
Apostolova, Sonia;
Guasch-Vallés, Marta;
Pryer, Aaron;
Unzueta, Fernando;
Freire, Raimundo;
Solé-Soler, Roger;
Pedraza, Neus;
Dolcet, Xavier;
Garí, Eloi;
Agell, Neus;
Taylor, Elaine M;
Colomina, Neus;
Torres-Rosell, Jordi

Publication type:

Article