Objective This paper reports a case of Plasmodium ovale and SARS-CoV-2 coinfection, which was successfully cured under the strategy of early diagnosis, timely antiviral and anti-malarial treatment, offering a reference for clinical diagnosis and treatment of this disease. Methods The epidemiological history, clinical manifestations, treatment status and laboratory results of the case were collected for case analysis. Results The patient had a history of travel to malaria and COVID-19 epidemic areas, and had repeated fever after admission, accompanied by headache, fatigue, throat discomfort and muscle soreness. Laboratory results showed abnormal liver function, decreased hemoglobin concentration, decreased lymphocyte and platelet counts. Blood Plasmodium tests showed negative by malaria rapid diagnostic test and the microscopic test showed Plasmodium, PCR was positive for Plasmodium ovale, the nasopharyngeal swab detected SARS-CoV-2, lung CT showed inflammatory foci in the lower lobe of the right lung. Plasmodium ovale malaria with COVID-19 coinfection was diagnosed. After antiviral and antimalarial treatment, he was cured. Conclusions The clinical manifestations of Plasmodium ovale co -infection with SARS-CoV-2 are complicated, and laboratory tests are easy to miss. Early diagnosis and timely targeted treatment can achieve good results.