Risk factors of immunoprophylaxis failure of infants borned by HBsAg positive mothers in Quanzhou, Fujian.

HUANG Cai-hong; CHEN Qiu-ting; CHEN Ya-hong; ZHANG Yang; ZENG Shan-shan; YE Zhen-fei

Objective To research the influence factors about neonatal hepatitis B immunization failure borned by HBsAg positive mothers in Quanzhou City, and we provide effective intervention measures for reducing the risk of neonatal hepatitis B virus infection. Methods A 1:2 case-control study was conducted. We respectively launched a questionnaire survey on 118 pairs newborns and mothers who failed to immunize with HepB and 236 pairs successfully immunized. χ² test and multivariate Logistic regression analysis were performed by SPSS 24.0 software. The exact probability method and continuous correction analysis method were used at the same time.Results The failure of neonatal immunization were related to the type and dose of hepatitis B vaccine, the mother's HBeAg status and HBV DNA load. The risk of immunization failure of newborn vaccinated with 20 µg hepatitis B vaccine was 0.147 times compared with who vaccinated by 10 µg (OR=0.147, Ptrend=108.922, P<0.001). Conclusions Pregnant women with HBeAg-positive and high HBV replication level was the major risk population of HBV mother-to-infant transmission. It was recommended that pregnant women with high HBV DNA viral load should be treated with antiviral therapy, and their newborns need to be vaccinated with 20 µg hepatitis B vaccine.

China Tropical Medicine, 2021, Vol 21, Issue 6, p562

1009-9727

Academic Journal

10.13604/j.cnki.46-1064/r.2021.06.12