Drug resistance and genotypes of HIV-infected patients with antiviral therapy in 4 border cities and counties in Chongzuo, Guangxi.

BAO Li-juan; CHEN Ning; NONG Ai-dan; QU Yan-yun; WU Zhen-xian; WEI Guang-wu; LIU De-ping; YANG Yao; LIANG Bing-yu

Objective To determine the prevalence of HIV-1 genotypes and related factors among human immunodeficiency virus (HIV) infectors and acquired immune deficiency syndrome (AIDS) patients receiving anti-retrovirus therapy (ART) in Chongzuo, a border city of Guangxi, we performed the drug resistance analysis to provid scientific basis for optimizing the antiviral treatment schemes of those patients. Methods The pol gene sequences and information of antiviral treatment of 371 patients who received the national free antiretroviral therapy in Daxin, Ningming, Pingxiang and Longzhou counties from January 2018 to September 2018 were enrolled. The obtained sequences were submitted to Stanford HIV drug resistance database for subtypes and drug resistance analysis. Results There were 62 patients (16.7%) with drug resistance were identified among the 371 patients, of which CRF01_AE (72.6%) and CRF08_BC (22.6%) were the dominant subtypes. Drug resistance mostly occurred in NNRTIs (75.8%), especially EFV and NVP, of which K103N was the dominant mutation site. Results of Logistic regression analysis showed that patients from Longzhou (OR=3.392, 95%CI:1.093-10.525), infected with CRF_08BC subtype (OR=9.431, 95%CI: 3.296-26.985), changed the therapy (OR=2.662, 95%CI: 1.241-5.708) were close related to the occurrence of drug resistance. Genetic distance analysis showed that CRF01_AE>CRF08_BC>CRF07_BC; in different subtypes, the genetic distance of drug-resistant group was greater than that of non-drug-resistant group. Conclusion HIV/AIDS patients with ART have a severe prevalence of drug resistance mutations in Guangxi border area. Therefore, rational use of drugs and HIV-1 resistance surveillance should be enhanced, and medication compliance should be improved.

China Tropical Medicine, 2021, Vol 21, Issue 6, p512

1009-9727

Academic Journal

10.13604/j.cnki.46-1064/r.2021.06.03