Title: Enhanced Osteoclastogenesis in 4-1BB-Deficient Mice Caused by Reduced Interleukin-10.
Authors: Hyun-Hee Shin; Ji-Eun Lee; Eun A Lee; Byoung Se Kwon; Hye-Seon Choi
Abstract: The article studies whether 4-1BB and 4-1BB ligand interaction plays a role in osteoclastogenesis, using 4-1BB-deficient mice. 4-1BB is an inducible T-cell constimulatory molecule and a member of the tumor necrosis factor (TNF) receptor family. Enhanced osteoclastogenesis was observed in bone marrow-derived macrophage cells from 4-1BB-deficient mice than in those from wildtype mice.
Subjects: OSTEOCLASTS; T cells; INTERLEUKIN-10; TUMOR necrosis factors; BONE marrow
Publication: Journal of Bone & Mineral Research, 2006, Vol 21, Issue 12, p1907
ISSN: 0884-0431
Publication type: Academic Journal
DOI: 10.1359/JBMR.060813

Enhanced Osteoclastogenesis in 4-1BB-Deficient Mice Caused by Reduced Interleukin-10.

Hyun-Hee Shin; Ji-Eun Lee; Eun A Lee; Byoung Se Kwon; Hye-Seon Choi