儿童先天性白内障发病的影响因素分析及人工晶状体植入术后 屈光状态的变化研究.

梁金才; 李秉倩; 朱健华; 林宇驰; 蒋 平

Objective: To explore the influencing factors of congenital cataract in children, and to study the changes of refractive state after intraocular lens (IOL) implantation. Methods: 98 children with congenital cataract who were treated in our hospital from April2017 to February 2019 were selected as the case group, and 80 healthy children who came to our hospital for pediatric ophthalmic examination in the same period were selected as the control group. Univariate and multivariate Logistic regression were used to analyze the influencing factors of congenital cataract. All the patients in the case group underwent congenital cataract extraction combined with IOL implantation. The patients in the case group were followed up for 3 years, and the changes of diopter and axial length at 1, 2 and 3years after operation were compared. Results: Univariate analysis showed that the incidence of congenital cataract was not related to gender, threatened abortion during pregnancy, pregnancy induced hypertension, pregnancy induced diabetes, hyperthyroidism or hypothyroidism, anemia (P＞0.05). The incidence of congenital cataract was related to gestational age, birth weight, family history of congenital cataract, whether with infection in the first 2 months before pregnancy or during pregnancy and hypoxic ischemic encephalopathy (P<0.05). Multivariate Logistic regression analysis showed that gestational age <37 weeks, birth weight <2500 g, family history of congenital cataract, infection in the first 2 months before pregnancy or during pregnancy were the risk factors for congenital cataract (P<0.05). At the same time point, the increase of axial length and the change of diopter in patients < 2 years old group were greater than those in 2~6 years old group and 7~12 years old group, and those in 2~6 years old group were greater than those in 7~12years old group (P<0.05). Conclusion: Gestational age < 37 weeks, birth weight < 2500g, family history of congenital cataract, infection in the first 2 months before pregnancy or during pregnancy are the risk factors of congenital cataract. In addition, after children with congenital cataract received IOL treatment, IOL had a slight impact on their eye development.

GESTATIONAL diabetes; CEREBRAL anoxia-ischemia; LOGISTIC regression analysis; CHILDREN'S hospitals; CATARACT surgery; PHACOEMULSIFICATION; DENTAL extraction

Progress in Modern Biomedicine, 2023, Vol 23, Issue 4, p792

1673-6273

Academic Journal

10.13241/j.cnki.pmb.2023.04.037