Objective: To investigate the effect of phacoemulsification combined with different surgical methods on vision, hemodynamics and quality of life in patients with glaucoma and cataract. Methods: The clinical data of 56 patients (66 eyes) with glaucoma and cataract who were admitted to our hospital from January 2015 to August 2019 were analyzed retrospectively. According to the different operation methods, they were divided into two groups: group A(n=27, phacoemulsification combined with trabeculectomy) and group B (n=29, phacoemulsification combined with angle separation). The visual acuity, intraocular pressure, hemodynamics and quality of life of the two groups were compared. The complications of the two groups were counted. Results: The visual function index (VF-14) of the two groups increased in 1 month after operation, 3 months after operation and 6 months after operation, and group B was higher than group A (P<0.05). The visual acuity of the two groups increased first and then decreased at 1, 3 and 6 months after operation, and it was higher at 1, 3 and 6 months after operation than that before operation(P<0.05). The visual acuity of group B was higher at 3 and 6 months after operation than that of group a(P<0.05). The intraocular pressure of the two groups decreased continuously from 1 month to 6 months after operation, and group B was lower than that of group A (P<0.05). The end diastolic velocity (EDV) and peak systolic velocity (PSV) in group B were higher than that in group A (P<0.05), and the resistance index (RI) was lower in group B than that in group A (P<0.05). There was no significant difference in the incidence of complications between the two groups (P<0.05). Conclusion: Compared with phacoemulsification combined with trabeculectomy, phacoemulsification combined with angle separation is better in improving vision, intraocular pressure, hemodynamics and quality of life of patients with glaucoma combined with cataract, and does not increase the incidence of complications.