Title: High levels of regulatory T cells in blood are a poor prognostic factor in patients with diffuse large B-cell lymphoma.
Authors: Chen Chang; Shang-Yin Wu; Yu-Wei Kang; Kun-Piao Lin; Tsai-Yun Chen; Medeiros, L. Jeffrey; Kung-Chao Chang; Chang, Chen; Wu, Shang-Yin; Kang, Yu-Wei; Lin, Kun-Piao; Chen, Tsai-Yun; Chang, Kung-Chao
Abstract: Objectives: Host immunity likely plays a role in preventing progression of diffuse large B-cell lymphoma (DLBCL). Analysis of host immune cells may provide useful information for assessing prognosis or possibly clinical management.Methods: Peripheral blood samples from 77 patients with DLBCL and 30 healthy volunteers were analyzed using flow cytometry immunophenotyping. CBC counts, T-cell subsets, and dendritic cells (DCs) were detected, and the results were correlated with clinicopathologic characteristics.Results: Compared with healthy volunteers, patients with DLBCL had significantly higher leukocyte and monocyte counts (P Conclusions: Changes in blood immune cells occur in patients with DLBCL. The results also support a suppressive role of Tregs in adaptive immunity and correlate with poor-risk prognostic factors.
Subjects: LYMPHOMAS; T cells; BLOOD cells; B cells; ANTINEOPLASTIC agents; FLOW cytometry; PROGNOSIS
Publication: American Journal of Clinical Pathology, 2015, Vol 144, Issue 6, p935
ISSN: 0002-9173
Publication type: Academic Journal
DOI: 10.1309/AJCPUJGMVV6ZF4GG

High levels of regulatory T cells in blood are a poor prognostic factor in patients with diffuse large B-cell lymphoma.

Chen Chang; Shang-Yin Wu; Yu-Wei Kang; Kun-Piao Lin; Tsai-Yun Chen; Medeiros, L. Jeffrey; Kung-Chao Chang; Chang, Chen; Wu, Shang-Yin; Kang, Yu-Wei; Lin, Kun-Piao; Chen, Tsai-Yun; Chang, Kung-Chao