Eliminating punishment can lead to a lack of focus or the emergence of bad habits that can affect the teaching and learning process. The purpose of this research is 1) to find the effects of using punishment, reward, exercise, and test (fatigue method), 2) to find The Contiguous Conditioning Theory using fatigue method in one single trial learning can be a new technique in learning English. The treatment is the application of Guthrie's theory using fatigue method in one single trial learning in the English Course class. Posttest-Only control design is an experimental study that compares two groups were given different treatment. The result shows that the use of Guthrie theory of fatigue method in one single trial learning gives different results compared to the result of conventional theory. The experimental group shows better average student learning outcomes than the control group. The hypothesis is succeeded and the Guthrie theory of fatigue method in one single trial learning can be used as a new method in teaching English. Guthrie's theory is effective in building students' understanding or thinking that the final grade is important, not just a standard for passing a lesson.