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- Title
A murine model for the immunotherapy of head and neck squamous cell carcinoma.
- Authors
Hier, M.P.; Black, M.J.; Shenouda, G.; Sadeghi, N.; Karp, S.E.
- Abstract
A murine model for the immunotherapy of head and neck cancer was established. The AT-84 tumor, a spontaneously arising oral squamous cell tumor of C3H mice, was evaluated for susceptibility to lymphokine-activated killer (LAK) cells. In vitro chromium-release assays demonstrated that AT-84 is sensitive to LAK-cell-mediated killing. Furthermore, in vivo experiments employing a lung metastasis model demonstrated a 50% reduction in the number of metastases in LAK-cell-treated mice as compared with untreated controls (P2=.001). These experiments showed that AT-84 is an appropriate model for the immunotherapy of head and neck cancer. This model should be invaluable for further study of the mechanisms involved in immune-mediated therapy of head and neck cancer.
- Publication
Laryngoscope, 1995, Vol 105, Issue 10, p1077
- ISSN
0023-852X
- Publication type
Academic Journal
- DOI
10.1288/00005537-199510000-00013