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- Title
Corn silk induced cyclooxygenase-2 in murine macrophages.
- Authors
Kim, Kyung A; Shin, Hyun-Hee; Choi, Sang Kyu; Choi, Hye-Seon
- Abstract
Stimulation of murine macrophages with corn silk induced cyclooxygenase (COX)-2 with secretion of PGE2. Expression of COX-2 was inhibited by pyrolidine dithiocarbamate (PDTC), and increased DNA binding by nuclear factor kappa B (NF-kappaB), indicating that COX-2 induction proceeds also via the NF-kappaB signaling pathway. A specific inhibitor of COX-2 decreased the expression level of inducible nitric oxide synthase (iNOS) stimulated by corn silk. PGE2 elevated the expression level of iNOS, probably via EP2 and EP4 receptors on the surface of the macrophages.
- Publication
Bioscience, biotechnology, and biochemistry, 2005, Vol 69, Issue 10, p1848
- ISSN
0916-8451
- Publication type
Journal Article
- DOI
10.1271/bbb.69.1848